Dr. Bob's Psychopharmacology Tips

Choice of second-line meds for ADHD

Date: Fri, 12 Jan 1996 21:18:12 EST
From: HRudMD@aol.com (Howard Rudominer, M.D.)
Subject: Choice of second-line meds for ADHD

I think it is a toss up these days between guanfacine (Tenex) and bupropion (Wellbutrin) as the second line of meds [after methylphenidate and dextroamphetamine] for ADHD.

Date: Tue, 17 Dec 1996 09:52:38 -0800
From: "Kenneth W. Steinhoff" <ksteinho@uci.edu>
Subject: Choice of second-line meds for ADHD

The meds that seem to work effect the norepinephrine system. Thus, routine 2nd line agents are buproprion, venlafaxine, clonidine, and desipramine/imipramine.

The best literature for this is in the Journal of the American Academy of Child Psychiatry and includes trials of buproprion and guanfacine, debates about sudden death with desipramine, etc.

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