Date: Sun, 10 Nov 1996 20:33:27 -0500
From: Ivan Goldberg <Psydoc@psycom.net>
Subject: Adderall for child ADD
It is interesting to see the controversy about Adderall. I would have predicted that Adderall would be too similar to Dexedrine to add any advantage. However I have found it to be as different as Ritalin. I don't think there is any predictability regarding response to Ritalin (methylphenidate), Dexedrine (dextroamphetamine), Adderall, or Cylert (pemoline). One may work or cause side effects when the other doesn't. I think my Adderall responders are unexpected because they are the Ritalin or Dexedrine failures. If I gave Adderall first, I would probably find similar difficulties with it.
--John M. Diamond
Date: Mon, 11 Nov 1996 00:54:08 -0500
Subject: Adderall for adult ADD
I have had good experience with Adderall in adult ADD. I have tried it in approximately 9 adults thus far. In about 6 it was a switch from methylphenidate, in 3 the first drug used. 5 of the 6 found it superior to methylphenidate in that it was longer lasting (4-6 hours versus 2.5-4). One found it less efficacious, but only tried it for a short period. Of the 3, 2 had a positive effect on concentration, restlessness, and moodiness, and one had no effect. The dosage range in the group was 10-20 mg q 4-6 hours, up to 3 times per day. No significant side effects (no agitation, nor headache, nor tachycardia) have been noted.
Overall, the effect does seem longer lasting and smoother, without evidence of rebound. I do not know if this is due to the mechanism postulated by the company, the different amphetamine salts in Adderall being metabolized at differing rates, thus creating a series of peaks, or some other mechanism. I am well aware of how uncontrolled and impressionistic the above data is. I find Adderall a good addition to the adult ADD armamentarium.
Date: Wed, 20 Nov 96 01:36:16 UT
From: "dan steinfink" <firstname.lastname@example.org>
Subject: Adderall for ADD
In a message dated 11/14/96 11:18:45 AM, dtr01@PRIMERA.ORG (Doug Russo) wrote:
Adderall is the trade name of a combination amphetamine product which was recently re-released into the U.S. market after being withdrawn in October of 1994 (after being released as Adderall after being withdrawn as Obetrol -- for obesity -- in 1973). It is available as a 10 or 20 mg tablet containing either 2.5 or 5 mg each of:I use all stimulant meds to treat ADD in people of all ages. I find most patients prefer Dexedrine or Adderall over Ritalin because of longer duration of action and less rebound irratibility. Nevertheless some will have more side effects with Dexedrine or Adderall and prefer Ritalin. There is lots of trial and error.
Apparently, the salts produce a long-acting effect which can be administered once daily and is indicated for children greater than 3-5 years old with ADHD. The ingredients apparently posses the same pharmacology as dextroamphetamine. More information can be obtained from the FDC Pink Sheet: Prescription Pharmaceuticals & Biotechnology 1996: T & G 4-5, 2/26/96.
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