Psycho-Babble Substance Use Thread 495679

Shown: posts 1 to 7 of 7. This is the beginning of the thread.

 

Another question ...

Posted by AMD on May 9, 2005, at 18:10:57

I took a 50 m.g. dose of Seroquel about six hours following my intake of ketamine and cocaine. Any chance this may have exasperated the effects of the latter drugs? I read an alarmist paper that mixing ketamine and an antipsychotic can cause severe brain damage, even the first time. What is the reality of this?

Finally -- today I felt pretty bad. Lamictal 300 mg this morning, coming off two days of 50 m.g. of Seroquel, and 80 m.g. of Celexa this morning as well. Any chance my slight tongue tingling, zoned-out feeling, and generally ill state is related to those medications (particularly the Seroquel).

Chemist, can you recommend a good textbook for self-study in chemistry? I took chemistry in high school but have largely (if not completely) forgotten its basics. I've been studying calculus but right now I feel pretty useless. The thought of opening a book makes me depressed. I hate that "I will never be able to learn anything new again" feeling. I hope this, too, passes and is related to the depression rather than anything else.

Finally, I suppose many of these symptoms I feel /are/ related to the depression. When I hear "memory loss" I forget that perhaps that is independent of depression, and that any slowness of mind I feel right now is due to the depression, not memory loss specifically. (I assume one can have memory loss and not feel mentally and physically depressed.)

amd

 

Re: Another question ... AMD

Posted by chemist on May 9, 2005, at 20:28:25

In reply to Another question ..., posted by AMD on May 9, 2005, at 18:10:57

hello again, answers/suggestions with asterisks...yours, c


> I took a 50 m.g. dose of Seroquel about six hours following my intake of ketamine and cocaine. Any chance this may have exasperated the effects of the latter drugs? I read an alarmist paper that mixing ketamine and an antipsychotic can cause severe brain damage, even the first time. What is the reality of this?

***** there is a finite chance of all kinds of phenomena happening once, given long enough time, yet that is not of import. seroquel should have reduced any psychoses associated with ketamine if present, but i suspect that given the skewed affinity (high) for D_{3} and not for NE/E that the seroquel and ketamine interaction was minimal. huffing paint thinner out of a paper bag - even the first time - can cause brain damage. the list of things to avoid with your ketamine when administered by an anesthesiologist as you are prepped for surgery is addressed by the person who is literally responsible for your life. anything that inhibits metabolism of ketamine == increase in blood pressure and trouble. apparently, i.v. ketamine + diazepam or barbiturates == formation of (insoluble, yes) precipitate. the list goes on...****
>
> Finally -- today I felt pretty bad. Lamictal 300 mg this morning, coming off two days of 50 m.g. of Seroquel, and 80 m.g. of Celexa this morning as well. Any chance my slight tongue tingling, zoned-out feeling, and generally ill state is related to those medications (particularly the Seroquel).
>
**** yes, a chance, and wondering why the up and down with seroquel? ****

> Chemist, can you recommend a good textbook for self-study in chemistry? I took chemistry in high school but have largely (if not completely) forgotten its basics. I've been studying calculus but right now I feel pretty useless. The thought of opening a book makes me depressed. I hate that "I will never be able to learn anything new again" feeling. I hope this, too, passes and is related to the depression rather than anything else.
>
***** any general chem text published in the last five years or so will do. be warned: many people will claim that there is no such thing as a good chemistry text, and most chemistry people probably agree to a point. ******

> Finally, I suppose many of these symptoms I feel /are/ related to the depression. When I hear "memory loss" I forget that perhaps that is independent of depression, and that any slowness of mind I feel right now is due to the depression, not memory loss specifically. (I assume one can have memory loss and not feel mentally and physically depressed.)
>
> amd

*** ask larry, i can opine, but.....****

 

Re: Another question ... chemist

Posted by AMD on May 9, 2005, at 21:35:49

In reply to Re: Another question ... AMD, posted by chemist on May 9, 2005, at 20:28:25

> ***** there is a finite chance of all kinds of phenomena happening once, given long enough time, yet that is not of import. seroquel should have reduced any psychoses associated with ketamine if present, but i suspect that given the skewed affinity (high) for D_{3} and not for NE/E that

### I didn't feel a thing on ketamine, so perhaps its effect was minimal irrespective of the other chemicals parading through my brain. My concentration is off -- I find myself easily distracted, and have a hard time focusing on anything in-depth -- but I am hoping this will pass in the next few days. The best I can do is hope and avoid the cocaine. ###

huffing paint thinner out of a paper bag - even the first time - can cause brain damage

### Point being? This is something I certainly never, ever want nor intend to do. I think even in a serious alcoholic, uninhibited stupor I wouldn't touch that. I have an innate fear of solvents and other toxic fumes. You know this ;) ###

> >
> **** yes, a chance, and wondering why the up and down with seroquel? ****

### I felt pretty lousy the day after, and popped a couple Seroquel two nights in row to continue a prolonged slumber. Rebound hypersomnia and then some. Probably wasn't the smartest move, but perhaps it explains some of the pseudostupor I'm having today -- slight slurring of speech in particular (I believe this has happened before and passed, but anything to worry about here aside from the depression as its possible cause?).

I need to quit obsessing about this ... it's done, the brain is quite flexible in its reaction to toxic substances, and the fact that I am able to concentrate at least a little bodes well that I'll recover within days. At least, unless there's a delayed onset of these drugs' effects. I wonder. ###

> *** ask larry, i can opine, but.....****

### I believe I've scared Larry from this board.###

amd

 

Re: Another question ... AMD

Posted by chemist on May 9, 2005, at 22:04:33

In reply to Re: Another question ... chemist, posted by AMD on May 9, 2005, at 21:35:49

> > ***** there is a finite chance of all kinds of phenomena happening once, given long enough time, yet that is not of import. seroquel should have reduced any psychoses associated with ketamine if present, but i suspect that given the skewed affinity (high) for D_{3} and not for NE/E that
>
> ### I didn't feel a thing on ketamine, so perhaps its effect was minimal irrespective of the other chemicals parading through my brain. My concentration is off -- I find myself easily distracted, and have a hard time focusing on anything in-depth -- but I am hoping this will pass in the next few days. The best I can do is hope and avoid the cocaine. ###

$$$ hello again....i think the bottom line is that the booze likely overshadows everything, with the very short exceptions of the coke, and there are a lot of variables in the mix to consider. the plan sounds good and stick to it, a lot of the substance use is hand-in-hand - like cigarettes and booze, a classic... $$$
>
> huffing paint thinner out of a paper bag - even the first time - can cause brain damage
>
> ### Point being? This is something I certainly never, ever want nor intend to do. I think even in a serious alcoholic, uninhibited stupor I wouldn't touch that. I have an innate fear of solvents and other toxic fumes. You know this ;) ###
>
$$$ no insinuation on my part, just that one time use of anything might be an outlier and the further one goes into lack of QA/QC on substance, dose, other substances, the more likely a hit. this is why i suggested that the alcohol, mood, and meds combo is a larger handful to manage than (arguably?) alcohol/mood; mood/meds; or alcohol/meds. that is a likely reason your pdoc - and i would assume many - make it clear that the drug/alcohol introduction is a no-go, as it is up to the patient to monitor, and they might not be in the right range to make the therapy/meds effective to the prescriber. $$$
> > >
> > **** yes, a chance, and wondering why the up and down with seroquel? ****
>
> ### I felt pretty lousy the day after, and popped a couple Seroquel two nights in row to continue a prolonged slumber. Rebound hypersomnia and then some. Probably wasn't the smartest move, but perhaps it explains some of the pseudostupor I'm having today -- slight slurring of speech in particular (I believe this has happened before and passed, but anything to worry about here aside from the depression as its possible cause?).

$$$ if it lasts a few days and gets worse and (very important here) an unsolicited comment to you by a friend/colleague/etc. along the lines of ``are you drunk?'' or ``why are you slurring?'' means you really *are* slurring your speech and not fixating upon the possibility and making it a reality...$$$$
>
> I need to quit obsessing about this ... it's done, the brain is quite flexible in its reaction to toxic substances, and the fact that I am able to concentrate at least a little bodes well that I'll recover within days. At least, unless there's a delayed onset of these drugs' effects. I wonder. ###

$$$$ not coke, ketamine, alcohol, probably 2000+ compounds in cigarettes, or pot in terms of producing the desired effect; it takes longer for the scripted meds to do their thing or not, as you know...$$$$
>
> > *** ask larry, i can opine, but.....****
>
> ### I believe I've scared Larry from this board.###
>
> amd
>
$$$ oh, i doubt it...)....yours, chemist $$$

 

Re: Another question ... chemist

Posted by AMD on May 9, 2005, at 22:31:37

In reply to Re: Another question ... AMD, posted by chemist on May 9, 2005, at 22:04:33

>I'm having today -- slight slurring of speech in particular (I believe this has happened before and passed, but anything to worry about here aside from the depression as its possible cause?).
>
> $$$ if it lasts a few days and gets worse and (very important here) an unsolicited comment to you by a friend/colleague/etc. along the lines of ``are you drunk?'' or ``why are you slurring?'' means you really *are* slurring your speech and not fixating upon the possibility and making it a reality...$$$$

.=.=.=.
It's more of an exaggeration to my natural lisp.

Well, we'll see what happens. I think it's more of a psychological effect -- I don't think I'm actually (significantly) slurring my words. God I hope not. If so, what would that indicate? A stroke? And if so, what would be my prognosis? Wouldn't I know if I'd had one? Is a stroke likely when I'm in relatively good shape, run regularly, etc.? Of course mixing uppers and downers is never a good idea ...

[I think at this point I'm keeping the thread going to see how creative we can get with our delimiters.]

.=.=.=.

amd

 

Re: Another question ... AMD

Posted by Larry Hoover on May 11, 2005, at 22:41:23

In reply to Re: Another question ... chemist, posted by AMD on May 9, 2005, at 21:35:49

> I need to quit obsessing about this ...

I think that is the simplest way of saying exactly what you must do.

> ### I believe I've scared Larry from this board.###
>
> amd

Out of respect for the topical importance to you, I haven't ventured back onto the board just now.....I am spread too thin.

I shall be back. Hopefully soon.

Until then, please, your worry is doing you more harm than the drugs you took could possibly have done. Seriously.

Breathing exercises really work. In through the nose, out through the mouth.

Start with a sigh. Then close your mouth, and inhale deeply through your nose. You need to feel your belly expand, as your diaphragm drops down. When you've inhaled completely, pause. There's no set time to pause....just do it. Then, purse your lips, and exhale until you are empty. Pause. Repeat, as many times as it takes.

Talk later, eh?

Lar

 

Re: Another question ... Larry Hoover

Posted by AMD on May 12, 2005, at 17:53:16

In reply to Re: Another question ... AMD, posted by Larry Hoover on May 11, 2005, at 22:41:23

I'll try that, Larry. Thank you.

Enjoy your sabbatical.

amd


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