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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Tabitha on November 24, 2017, at 22:45:20
In reply to Curcumin/turmeric? I'm hypersensitive to ADs, posted by Mtom on November 24, 2017, at 16:16:43
> I'm reading different hypotheses/speculations on how (and if) Curcumin/Turmeric alleviates depression. I can't tolerate Antidepressant side effects - intense Anxiety/Agitation for one.
>
> There is evidence I'm a slow metabolizer which might at least in part account for this hypersensitivity. It also might be meaningful with regards to curcumin which I've read can also impact the Phase 1 P450 enzyme system.
>
> I've been researching and some say Curcumin does "not" work like an AD, others say it does.
>
> Has it worked for anyone for depression (and/or anxiety)? Has anyone experienced side effects? What is a good starting dose (I'm a very small person)?
>
> Thanks!
Posted by sigismund on November 26, 2017, at 0:08:56
In reply to Re: Curcumin/turmeric? I'm hypersensitive to ADs » Mtom, posted by Tabitha on November 24, 2017, at 22:45:20
I've taken the BCM extract at 800mg/d - 1,600mg/d for cancer protection for 6 tears.
I have insomnia, anxiety and agitation and had it before I started. I do not think these have been affected. Things have been no different when I have run out.
Naturally I thought I should be careful at the higher dose.
A usual start would be 400mg/d if you were using the BCM extract.
> It also might be meaningful with regards to curcumin which I've read can also impact the Phase 1 P450 enzyme system.
If it did that, what might happen?
Posted by Mtom on December 2, 2017, at 16:31:05
In reply to Re: Curcumin/turmeric? I'm hypersensitive to ADs, posted by sigismund on November 26, 2017, at 0:08:56
You asked that if Curcumin impacts the liver P450 enzyme system, what could happen? This system is responsible for clearing many toxins and drugs (possibly some supplements) from the body. If under-functioning, it can result in a build up of drugs even at "normal" doses. It has been speculated this may be why I am hyper-sensitive to Antidepressants as most are cleared by this enzyme system.
> I've taken the BCM extract at 800mg/d - 1,600mg/d for cancer protection for 6 tears.
>
> I have insomnia, anxiety and agitation and had it before I started. I do not think these have been affected. Things have been no different when I have run out.
>
> Naturally I thought I should be careful at the higher dose.
>
> A usual start would be 400mg/d if you were using the BCM extract.
>
> > It also might be meaningful with regards to curcumin which I've read can also impact the Phase 1 P450 enzyme system.
>
> If it did that, what might happen?
Posted by Tony P on January 15, 2018, at 4:11:38
In reply to Re: Curcumin/turmeric as alternative to AD's? » sigismund, posted by Mtom on December 2, 2017, at 16:31:05
I have no direct experience with these supplements or extracts, but curries almost always contain considerable turmeric, and some are definitely mood elevating! This is usually attributed to endorphins from the PAIN of eating the burning hot curry, but I'm not convinced. I think some of the spices such as turmeric must have active principles that haven't yet been identified. I remember eating an unusual Indonesian curry, Sayor Lodeh, a deceptively innocent looking vegetable stew with coconut milk and a number of unusual herbs and spices, and walking out of the restaurant high as a kite!
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