![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by SLS on April 18, 2011, at 8:37:43
It looks like phosphatidylserine would help the brain recover by acting to produce neural membrane. Perhaps this substance would act synergistically with Omega-3.
Has anyone tried this combination?
- Scott
Posted by sigismund on April 18, 2011, at 14:15:17
In reply to Phosphatidylserine - Anyone?, posted by SLS on April 18, 2011, at 8:37:43
>Has anyone tried this combination?
Yes.
Do I have anything sensible to say about it?
No
I think Linkadge and Blueberry had negative results with PS.
Larry Hoover had some interesting things to say about it in the archives, IIRC.
Posted by 49er on April 19, 2011, at 15:41:35
In reply to Phosphatidylserine - Anyone?, posted by SLS on April 18, 2011, at 8:37:43
> It looks like phosphatidylserine would help the brain recover by acting to produce neural membrane. Perhaps this substance would act synergistically with Omega-3.
>
> Has anyone tried this combination?
>
>
> - ScottScott, you must have ESP because I was looking into trying this again.
For what it is worth, someone on an internet board said she tried all brands and settled on Nature's Way PS.
I decided since it is alot cheaper, I would buy lecithin granules since it seems to be pretty much the same compound. I brought mine at Whole Foods since I can return it for a full refund if it doesn't work.
Also, someone recommended it for chemo brain fog so that is another reason I thought I would give it a shot.
I have got to do something because this brain fog is not a good thing.
What led you to decide to try it?
I hope it works for you.
49er
Posted by SLS on April 20, 2011, at 7:11:08
In reply to Re: Phosphatidylserine - Anyone? » SLS, posted by 49er on April 19, 2011, at 15:41:35
Hi 49er.
A good friend of mine suggested the combination of fish oil and PS. When I researched these substances, I found that they were ideal to meet my desire to supply the brain with the raw materials to support healing. These two substances might be synergistic in promoting the repair of neuronal membranes and the growth of neurites. This is speculation on my part. I haven't received my order of fish oil yet, and I am not inclined to start PS at this juncture. Another substance that I chose to use to support neurotrophism is lithium. Low dosages of lithium (150-300 mg) increase cytosolic levels of BDNF and bcl-2, two substances that act as "hormones" for neuron growth and maintenance.
How does lecithin work?
Thanks.
- Scott> > It looks like phosphatidylserine would help the brain recover by acting to produce neural membrane. Perhaps this substance would act synergistically with Omega-3.
> >
> > Has anyone tried this combination?
> >
> >
> > - Scott
>
> Scott, you must have ESP because I was looking into trying this again.
>
> For what it is worth, someone on an internet board said she tried all brands and settled on Nature's Way PS.
>
> I decided since it is alot cheaper, I would buy lecithin granules since it seems to be pretty much the same compound. I brought mine at Whole Foods since I can return it for a full refund if it doesn't work.
>
> Also, someone recommended it for chemo brain fog so that is another reason I thought I would give it a shot.
>
> I have got to do something because this brain fog is not a good thing.
>
> What led you to decide to try it?
>
> I hope it works for you.
>
> 49er
>
Posted by 49er on April 20, 2011, at 10:56:39
In reply to Re: Phosphatidylserine - Anyone? » 49er, posted by SLS on April 20, 2011, at 7:11:08
Hi Scott,
I am not 100% sure of the but I think Lecithin works like PS since it is made of phospholipids which are similar to what is in that substance.
I definitely feel like my brain is more alive since I started taking it. I am trying to get the right dose as even though I only took 1/2 tsp for lunch, I feel too wired. Live and learn.
The advantage it is so much cheaper than PS,
49er
> Hi 49er.
>
> A good friend of mine suggested the combination of fish oil and PS. When I researched these substances, I found that they were ideal to meet my desire to supply the brain with the raw materials to support healing. These two substances might be synergistic in promoting the repair of neuronal membranes and the growth of neurites. This is speculation on my part. I haven't received my order of fish oil yet, and I am not inclined to start PS at this juncture. Another substance that I chose to use to support neurotrophism is lithium. Low dosages of lithium (150-300 mg) increase cytosolic levels of BDNF and bcl-2, two substances that act as "hormones" for neuron growth and maintenance.
>
> How does lecithin work?
>
> Thanks.
>
>
> - Scott
>
>
>
> > > It looks like phosphatidylserine would help the brain recover by acting to produce neural membrane. Perhaps this substance would act synergistically with Omega-3.
> > >
> > > Has anyone tried this combination?
> > >
> > >
> > > - Scott
> >
> > Scott, you must have ESP because I was looking into trying this again.
> >
> > For what it is worth, someone on an internet board said she tried all brands and settled on Nature's Way PS.
> >
> > I decided since it is alot cheaper, I would buy lecithin granules since it seems to be pretty much the same compound. I brought mine at Whole Foods since I can return it for a full refund if it doesn't work.
> >
> > Also, someone recommended it for chemo brain fog so that is another reason I thought I would give it a shot.
> >
> > I have got to do something because this brain fog is not a good thing.
> >
> > What led you to decide to try it?
> >
> > I hope it works for you.
> >
> > 49er
> >
>
Posted by SLS on April 20, 2011, at 12:58:48
In reply to Re: Phosphatidylserine - Anyone? » SLS, posted by 49er on April 20, 2011, at 10:56:39
Posted by floatingbridge on April 28, 2011, at 21:25:43
In reply to Re: Phosphatidylserine - Anyone? » SLS, posted by 49er on April 20, 2011, at 10:56:39
49er,
The lecithin sounds good. I remember my grandparents using it back in the 70's. I think our natural food market might sell it bulk.
I didn't realize there was synergy between fish oil and PS. Krill oil seems to help quite a bit at two months in. The PS was added by my gp about 3 weeks ago. Can't say I can tell. Yet. It's wickedly pricey.
fb
> Hi Scott,
>
> I am not 100% sure of the but I think Lecithin works like PS since it is made of phospholipids which are similar to what is in that substance.
>
> I definitely feel like my brain is more alive since I started taking it. I am trying to get the right dose as even though I only took 1/2 tsp for lunch, I feel too wired. Live and learn.
>
> The advantage it is so much cheaper than PS,
>
> 49er
>
> > Hi 49er.
> >
> > A good friend of mine suggested the combination of fish oil and PS. When I researched these substances, I found that they were ideal to meet my desire to supply the brain with the raw materials to support healing. These two substances might be synergistic in promoting the repair of neuronal membranes and the growth of neurites. This is speculation on my part. I haven't received my order of fish oil yet, and I am not inclined to start PS at this juncture. Another substance that I chose to use to support neurotrophism is lithium. Low dosages of lithium (150-300 mg) increase cytosolic levels of BDNF and bcl-2, two substances that act as "hormones" for neuron growth and maintenance.
> >
> > How does lecithin work?
> >
> > Thanks.
> >
> >
> > - Scott
> >
> >
> >
> > > > It looks like phosphatidylserine would help the brain recover by acting to produce neural membrane. Perhaps this substance would act synergistically with Omega-3.
> > > >
> > > > Has anyone tried this combination?
> > > >
> > > >
> > > > - Scott
> > >
> > > Scott, you must have ESP because I was looking into trying this again.
> > >
> > > For what it is worth, someone on an internet board said she tried all brands and settled on Nature's Way PS.
> > >
> > > I decided since it is alot cheaper, I would buy lecithin granules since it seems to be pretty much the same compound. I brought mine at Whole Foods since I can return it for a full refund if it doesn't work.
> > >
> > > Also, someone recommended it for chemo brain fog so that is another reason I thought I would give it a shot.
> > >
> > > I have got to do something because this brain fog is not a good thing.
> > >
> > > What led you to decide to try it?
> > >
> > > I hope it works for you.
> > >
> > > 49er
> > >
> >
>
>
Posted by floatingbridge on April 28, 2011, at 21:30:33
In reply to Re: Phosphatidylserine - Anyone? » 49er, posted by SLS on April 20, 2011, at 7:11:08
Scott,
Do you use prescription lithium? I was thinking about re-adding it, maybe, in a month or so. My market carries it as a supplement. I used to have it by prescription. Does the form matter much?
Thanks,
fb
> Another substance that I chose to use to support neurotrophism is lithium. Low dosages of lithium (150-300 mg) increase cytosolic levels of BDNF and bcl-2, two substances that act as "hormones" for neuron growth and maintenance.
>
> How does lecithin work?
>
> Thanks.
>
>
> - Scott
>
>
>
> > > It looks like phosphatidylserine would help the brain recover by acting to produce neural membrane. Perhaps this substance would act synergistically with Omega-3.
> > >
> > > Has anyone tried this combination?
> > >
> > >
> > > - Scott
> >
> > Scott, you must have ESP because I was looking into trying this again.
> >
> > For what it is worth, someone on an internet board said she tried all brands and settled on Nature's Way PS.
> >
> > I decided since it is alot cheaper, I would buy lecithin granules since it seems to be pretty much the same compound. I brought mine at Whole Foods since I can return it for a full refund if it doesn't work.
> >
> > Also, someone recommended it for chemo brain fog so that is another reason I thought I would give it a shot.
> >
> > I have got to do something because this brain fog is not a good thing.
> >
> > What led you to decide to try it?
> >
> > I hope it works for you.
> >
> > 49er
> >
>
Posted by SLS on May 19, 2011, at 4:44:15
In reply to Re: Phosphatidylserine - Anyone? » SLS, posted by floatingbridge on April 28, 2011, at 21:30:33
Hi FB.
> Do you use prescription lithium?
Yes. Plain old lithium carbonate.
> I was thinking about re-adding it, maybe, in a month or so. My market carries it as a supplement. I used to have it by prescription. Does the form matter much?
Orotate vs Carbonate
I'm not sure. There are no clinical investigations that I could find that would substantiate the idea that the two substances are bioequivalent. I would stick with prescription lithium simply because it is a proven product.
- Scott
Posted by SLS on May 19, 2011, at 4:46:39
In reply to Re: Phosphatidylserine - Anyone? » floatingbridge, posted by SLS on May 19, 2011, at 4:44:15
I am currently taking 200mg of phosphatidylserine. Can anyone comment on this? What dosages are most effective? This stuff really works (for me).
Thanks.
- Scott
Posted by SLS on May 21, 2011, at 7:45:52
In reply to Re: Phosphatidylserine - Ideal Dosage?, posted by SLS on May 19, 2011, at 4:46:39
> I am currently taking 200mg of phosphatidylserine. Can anyone comment on this? What dosages are most effective? This stuff really works (for me).
>
> Thanks.
>
>
> - Scott
Damn. Phosphatidylserine at 200 mg/day is causing me to feel worse. I then feel better after skipping a dose. I guess I have no better choice than to try 100 mg/day rather than give up on it.It's always something.
- Scott
Posted by floatingbridge on May 21, 2011, at 8:00:33
In reply to Re: Phosphatidylserine - Ideal Dosage?, posted by SLS on May 21, 2011, at 7:45:52
O.K. you know my limited knowledge here, but....
Could you take it every other day, even given a dose reduction?
Why do you feel it's having an adverse effect?
Posted by SLS on May 21, 2011, at 8:31:08
In reply to Re: Phosphatidylserine - Ideal Dosage? » SLS, posted by floatingbridge on May 21, 2011, at 8:00:33
> O.K. you know my limited knowledge here, but....
Perhaps *here*.
Your knowledge and understanding are expanding exponentially. You should pass me in no time.
> Could you take it every other day, even given a dose reduction?
That's a good idea.
> Why do you feel it's having an adverse effect?
I experienced a loss of energy, interest, and motivation. In addition, my thoughts were slowed and included depressed mood. Skipping one dose allowed me to feel better. I tried discontinuing the PS, but I think I lost some degree of improvement that restarting the PS recaptured. I have experimented with discontinuation and rechallenge twice with the same result.
My brain is a pain my my butt. Maybe I should stop standing on my head. Sitting might be a problem, though.
- Scott
Posted by floatingbridge on May 21, 2011, at 8:52:35
In reply to Re: Phosphatidylserine - Ideal Dosage? » floatingbridge, posted by SLS on May 21, 2011, at 8:31:08
>
> Your knowledge and understanding are expanding exponentially. You should pass me in no time.I don't think so. I don't want to pass you anyways :-) Thanks for the affirmation, though.
>
> > Could you take it every other day even given a dose reduction?
>
> That's a good idea.
>
> > Why do you feel it's having an adverse effect?
>
> I experienced a loss of energy, interest, and motivation. In addition, my thoughts were slowed and included depressed mood. Skipping one dose allowed me to feel better. I tried discontinuing the PS,
but I think I lost some degree of improvement that restarting the PS
recaptured. I have experimented with discontinuation and rechallenge twice with the same result.
>
> My brain is a pain my my butt. Maybe I
should stop standing on my head. Sitting might be a problem, though.
>
>
> - Scott:+) It is true; if it's not one thing it's another. I'm glad your improvement is steady (!) even if it feels slow.
Posted by 49er on May 21, 2011, at 10:41:12
In reply to Re: Phosphatidylserine - Ideal Dosage? » SLS, posted by floatingbridge on May 21, 2011, at 8:52:35
Hi Scott,
I am sorry that PS isn't working for you. You were so hopeful and I know that is disappointing when something doesn't work out.
PS has been has had a very contradictory effect on me. I think it was responsible for my best night of sleep in months. Not 100% sure of that.
Also, when I talk on the phone, I feel more coherent.
But I am experiencing the other problems you report. So I am not sure how long I am going to stay on it.
Fortunately, due to a coupon, I got it quite cheaply so the money I would lose wouldn't be that much if it didn't work out.
49er
Posted by SLS on May 21, 2011, at 20:36:38
In reply to Re: Phosphatidylserine - Ideal Dosage?, posted by 49er on May 21, 2011, at 10:41:12
> Hi Scott,
>
> I am sorry that PS isn't working for you. You were so hopeful and I know that is disappointing when something doesn't work out.
>
> PS has been has had a very contradictory effect on me. I think it was responsible for my best night of sleep in months. Not 100% sure of that.
>
> Also, when I talk on the phone, I feel more coherent.
>
> But I am experiencing the other problems you report. So I am not sure how long I am going to stay on it.
>
> Fortunately, due to a coupon, I got it quite cheaply so the money I would lose wouldn't be that much if it didn't work out.
>
> 49er
I hope you don't mind if I say a prayer for you, regardless of its efficacy. :-)How much PS were you taking? Perhaps there is more to be had at lower dosages (therapeutic window). I had been taking 200 mg/day. I might retry it at 100 mg/day if I begin to deteriorate.
I am deferring to you to help certain people with the discontinuation of their BZDs or antidepressants. I hope you don't mind.
- Scott
Posted by SLS on May 26, 2011, at 6:10:59
In reply to Re: Phosphatidylserine - Ideal Dosage? » 49er, posted by SLS on May 21, 2011, at 20:36:38
I have discontinued phosphatidylserine. Even at 100mg, I experience a moderate exacerbation of my depression. I confirmed this by discontinuing it several times and restarting it as a challenge. Interestingly, I am pretty sure that it produced an improvement in depression for the first few days I took it during my first trial.
I am actually feeling well enough and am making sufficient gains such that I am disinclined to add anything other than fish oil to my regime.
- Scott
Posted by 49er on May 26, 2011, at 10:35:29
In reply to Re: Phosphatidylserine - Ideal Dosage? » 49er, posted by SLS on May 21, 2011, at 20:36:38
Hi Scott,
> I hope you don't mind if I say a prayer for you, regardless of its efficacy. :-)
Thanks, they are always welcomed:)
<< How much PS were you taking? Perhaps there is more to be had at lower dosages (therapeutic window). I had been taking 200 mg/day. I might retry it at 100 mg/day if I begin to deteriorate.>>
100 to 200mg. I quit it completely because I sensed it just wasn't going to be helpful. I am now taking DHA fish oil which seems alot better.
I see in another post you quit taking PS but are doing well otherwise. That is great to hear.
<< I am deferring to you to help certain people with the discontinuation of their BZDs or antidepressants. I hope you don't mind.>>
>
Not at all, I am very flattered. As an FYI, I do forget to check the site as evidenced by the lateness of this post:)If someone desperately wants to contact me, they can babble mail me if I am late in responding.
Also, I wanted to post the link to this support site for tapering off of antidepressants if anyone is interested.
http://survivingantidepressants.org/index.php?app=portal
It depends solely on individual donations and is not affiliated with any organization. Commercial links are not allowed on the site.
Much continued success Scott. You deserve it.
49er
Posted by floatingbridge on May 26, 2011, at 13:33:12
In reply to Re: Phosphatidylserine - Ideal Dosage?, posted by SLS on May 26, 2011, at 6:10:59
> I am actually feeling well enough and am making sufficient gains such that I am disinclined to add anything other than fish oil to my regime.
>:-) Yay! And one less supplement to buy. Fish oil maybe has cumulative effects. One could hope.
fb
>
> - Scott
This is the end of the thread.
Psycho-Babble Alternative | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.