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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by SLS on September 23, 2021, at 8:29:09
Hi, all.
I posted this within a thread earlier, but I felt it was important to post it as a new thread.
I have never met any clinician that knows as much as Linkadge does. I am pretty sure that there are only a few researchers who would have his *scope* of detailed knowledge. I am also impressed by his tempered use of critical thinking and logic. He never demonstrates the slightest hint of pretense.
I know that people respect my knowledge and thoughts, but perhaps they overestimate me.
THANK YOU, Linkadge.
I wouldn't be surprised if Linkadge preferred that I hadn't praised him this way. Humility.
- Scott
.
Posted by undopaminergic on September 23, 2021, at 12:17:14
In reply to A BIG thank you to Linkadge for his wealth of info, posted by SLS on September 23, 2021, at 8:29:09
> Hi, all.
>
> I posted this within a thread earlier, but I felt it was important to post it as a new thread.
>
> I have never met any clinician that knows as much as Linkadge does. I am pretty sure that there are only a few researchers who would have his *scope* of detailed knowledge. I am also impressed by his tempered use of critical thinking and logic. He never demonstrates the slightest hint of pretense.
>
> I know that people respect my knowledge and thoughts, but perhaps they overestimate me.
>
> THANK YOU, Linkadge.
>
> I wouldn't be surprised if Linkadge preferred that I hadn't praised him this way. Humility.
>
>
> - Scott
>A toast to Linkadge!
He is useful to have around, sometimes as a counter-balance to myself. In the thread you're referring to, he cast some doubt on Gillman's conclusions about venlafaxine, which is all the more significant in light of the fact that in general Gillman knows better than most.
-undopaminergic
Posted by linkadge on September 23, 2021, at 15:06:25
In reply to A BIG thank you to Linkadge for his wealth of info, posted by SLS on September 23, 2021, at 8:29:09
Thanks for the feedback. It's really a matter of trying to find answers to my own problems, and the problems of family members. You can only learn so much by reading drug leaflets. Being a member of this board and reading patient experiences has helped me learn so much. Of course, there are so many mental health mysteries that one day we will solve.
Linkadge
Posted by NKP on September 24, 2021, at 12:39:06
In reply to Re: A BIG thank you to Linkadge for his wealth of info » SLS, posted by undopaminergic on September 23, 2021, at 12:17:14
> > Hi, all.
> >
> > I posted this within a thread earlier, but I felt it was important to post it as a new thread.
> >
> > I have never met any clinician that knows as much as Linkadge does. I am pretty sure that there are only a few researchers who would have his *scope* of detailed knowledge. I am also impressed by his tempered use of critical thinking and logic. He never demonstrates the slightest hint of pretense.
> >
> > I know that people respect my knowledge and thoughts, but perhaps they overestimate me.
> >
> > THANK YOU, Linkadge.
> >
> > I wouldn't be surprised if Linkadge preferred that I hadn't praised him this way. Humility.
> >
> >
> > - Scott
> >
>
> A toast to Linkadge!
>
> He is useful to have around, sometimes as a counter-balance to myself. In the thread you're referring to, he cast some doubt on Gillman's conclusions about venlafaxine, which is all the more significant in light of the fact that in general Gillman knows better than most.
>
> -undopaminergic
>I also disagree with the views that Dr Gilman expresses on venlafaxine in his article "Venlafaxine: an enduring SNRI myth". He seems to argue that venlafaxine is basically just an SSRI at lower doses.
Curiously, Dr Gilman does recommend venlafaxine in one of his antidepressant algorithms, under Step 2a in
https://psychotropical.com/ken-gillman-ad-algorithm/.
The reasons for my disagreement with his appraisal are as follows:
1. On the SSRI front I've taken citalopram and sertraline. Neither of these ever caused insomnia. The first time I took venlafaxine, at only 75 mg per day, I had insomnia for two nights.
2. Venlafaxine has a reputation for its relatively worse side-effects compared to SSRIs. How can venlafaxine be basically just an SSRI, when it does not have the side-effect profile of an SSRI? The fact that it has worse side-effects that SSRIs suggests that it is doing something beyond what SSRIs do.
3. Linkadge has posted a study that utilises PET scans which seems to indicate that venlafaxine has greater in vivo noradrenergic activity than suggested from its in vitro binding affinities.
4. A 2007 study of Blier, often cited to substantiate the claim that venlafaxine isn't an NRI at lower doses, had only six subjects in each of its arms. The amateur statistician in me is sceptical whether one can reach statistical significance with a sample of only six subjects, especially for something like blood pressure readings which are fairly variable to start with.
In light of the fact that there is a widespread perception that the noradrenergic effects of venlafaxine only manifest at higher doses, I think that Dr Gilman's article should be re-titled: "Venlafaxine: an enduring SRI myth".
Posted by Jay2112 on September 24, 2021, at 18:44:40
In reply to A BIG thank you to Linkadge for his wealth of info, posted by SLS on September 23, 2021, at 8:29:09
Hey Scott!
> Hi, all.
>
> I posted this within a thread earlier, but I felt it was important to post it as a new thread.
>
> I have never met any clinician that knows as much as Linkadge does. I am pretty sure that there are only a few researchers who would have his *scope* of detailed knowledge. I am also impressed by his tempered use of critical thinking and logic. He never demonstrates the slightest hint of pretense.
>
> I know that people respect my knowledge and thoughts, but perhaps they overestimate me.
>
> THANK YOU, Linkadge.
>
> I wouldn't be surprised if Linkadge preferred that I hadn't praised him this way. Humility.Yes, Canadians (I believe Linkadge is Canuck) so he will be nice, polite, humble...LOL :) Yeah right!! I am Canuck, and there are scum of the earth Canucks too.......LOL..I think Link would agree with that.
>
> - Scott
>Jay
Posted by Jay2112 on September 24, 2021, at 19:06:24
In reply to Re: A BIG thank you to Linkadge for his wealth of info » SLS, posted by undopaminergic on September 23, 2021, at 12:17:14
> >
> > I know that people respect my knowledge and thoughts, but perhaps they overestimate me.
> >
> > THANK YOU, Linkadge.
> >
> > I wouldn't be surprised if Linkadge preferred that I hadn't praised him this way. Humility.
> >
> >
> > - Scott
> >
>
> A toast to Linkadge!
>
> He is useful to have around, sometimes as a counter-balance to myself. In the thread you're referring to, he cast some doubt on Gillman's conclusions about venlafaxine, which is all the more significant in light of the fact that in general Gillman knows better than most.
>
> -undopaminergic
>Well, he is *nice* to have around...period! :) I'd say...
And about Gillman...I agree with Linkadge... venlafaxine and desvenlafaxine have significant noradrenaline activity. I have been on the former for about 20 years now. I periodically switched. For me, compared to ALL SRI's, venlafaxine is far, far more stimulating. One factor that demonstrates the noradrenergic activity at work is the major REM suppression. Bur, this is very important, mainly because it is 'Real World' experiences that occur outside of the laboratory, usually over many years.
Jay
This is the end of the thread.
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