![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by undopaminergic on November 19, 2020, at 4:24:14
Hi all,
I was wondering if anyone has any thoughts on or experience with histamine H2-receptor antagonism.
Famotidine has shown promising results in the treatment of negative symptoms in schizophrenia. Negative symptoms are very much like depression, including apathy and anhedonia.
Trimipramine is a potent and high-affinity histamine H2-antagonist. Clozapine is an inverse agonist at the receptor.
In schizohprenia (famotidine):
https://pubmed.ncbi.nlm.nih.gov/23764683/In depression (ranitidine):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2417877/-undopaminergic
Posted by rjlockhart37 on November 20, 2020, at 14:23:37
In reply to Histamine H2-receptor antagonism, posted by undopaminergic on November 19, 2020, at 4:24:14
not sure if your in us, but zantac the antiacid, heart burn relief, it was removed from the market, i used to live on ranitidine because of excessivee acid burn, it worked so well, and they removed it, i have to stick with pepcid. I didnt really notice any mood improvement, but maybe passively it did and i just didnt notice the antidepressant effect.
I used to live on ranitidine, im serious because of acid issues, they removed it :(
Posted by linkadge on November 22, 2020, at 7:45:51
In reply to Histamine H2-receptor antagonism, posted by undopaminergic on November 19, 2020, at 4:24:14
It's hard to gage the effect with a lack of selective & potent (brain penetrant) H2 antagonists. I found famotidine seemed to have a bit of an anti-anxiety effect, but it's hard to tell. Supposedly you need high doses to enter the brain (?)
Linkadge
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.