Psycho-Babble Medication Thread 1110020

Shown: posts 1 to 6 of 6. This is the beginning of the thread.

 

How strong is Amitriptyline's sedative effect?

Posted by Skeletor on May 8, 2020, at 11:30:06

Personal ecperience requested ;=)

 

Re: How strong is Amitriptyline's sedative effect?

Posted by linkadge on May 9, 2020, at 8:09:48

In reply to How strong is Amitriptyline's sedative effect?, posted by Skeletor on May 8, 2020, at 11:30:06

It's fairly potent, but it can reduce over time (as it is also a potent SNRI). I found mirtazapine more sedating (but also less effective as an antidepressant).

Linkadge

 

Re: How strong is Amitriptyline's sedative effect? linkadge

Posted by Skeletor on May 10, 2020, at 15:06:52

In reply to Re: How strong is Amitriptyline's sedative effect?, posted by linkadge on May 9, 2020, at 8:09:48

> It's fairly potent, but it can reduce over time (as it is also a potent SNRI). I found mirtazapine more sedating (but also less effective as an antidepressant).
>
> Linkadge

I am on Escitalopram 5mg, which is okay. That is 60% SERT occupancy. (I can't stand strong SRIs. Zoloft 50mg, 75mg and 100mg made me a zombie and anorectic)

Now I ve been thinking about adding something with 5HT2 antagonism. I once tried Mirtazapine, but that gave me RLS. Amitriptyline has 5HT2 antagonism and additionally it has some powerful NRI and antimuscarinic action. It seems to be quite a potent med, but sedation frightens me.

 

Re: How strong is Amitriptyline's sedative effect?

Posted by linkadge on May 11, 2020, at 18:49:16

In reply to Re: How strong is Amitriptyline's sedative effect? linkadge, posted by Skeletor on May 10, 2020, at 15:06:52

If you're concerned about the sedative effect, you could add nortriptyline. Nortriptyline is less sedating, has 5-ht2 antagonism and might be more complementary (less SERT blockade).

Linkadge

 

Re: How strong is Amitriptyline's sedative effect? linkadge

Posted by Skeletor on May 12, 2020, at 17:06:56

In reply to Re: How strong is Amitriptyline's sedative effect?, posted by linkadge on May 11, 2020, at 18:49:16

> If you're concerned about the sedative effect, you could add nortriptyline. Nortriptyline is less sedating, has 5-ht2 antagonism and might be more complementary (less SERT blockade).
>
> Linkadge

Hmm yes, that might be worth thinking about. It's just a pain that there are only 10mg and 25mg pills where I live. That makes higher dosing a pain in the *ss.

btw: What is your take on Aripiprazole?

 

Re: How strong is Amitriptyline's sedative effect? Skeletor

Posted by linkadge on May 13, 2020, at 20:15:26

In reply to Re: How strong is Amitriptyline's sedative effect? linkadge, posted by Skeletor on May 12, 2020, at 17:06:56

I haven't taken Aripiprazole, so I can't say.

As far as nortriptyline dosing, if you're augmenting escitalopram, you probably wouldn't need much more than 50-75mg.

Linkadge


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