Psycho-Babble Medication Thread 1107190

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Pindolol (a beta-blocker) can alleviate depression

Posted by Hugh on December 11, 2019, at 12:37:41

[N]ine subjects with major depression unresponsive to paroxetine 40 mg/day given for 2 months or more were randomized to AM pindolol 7.5 mg (n=4) or placebo (n=5). Subjects were administered the Hamilton Depression Scale (HAM-D), the Hamilton Anxiety Scale (HAM-A), the Bech-Rafaelsen Melancholia Scale, and the Zung Depression Inventory at baseline and weeks 1, 2, 3, and 4. Subjects receiving pindolol exhibited significant improvements in all ratings beginning at week 2 which continued through week 4. Aside from transient dizziness and a five-point decrease in systolic/diastolic blood pressure associated with pindolol, no adverse effects were reported.

https://www.ncbi.nlm.nih.gov/pubmed/15006431

 

Re: Pindolol (a beta-blocker) can alleviate depression Hugh

Posted by phidippus on December 11, 2019, at 18:53:22

In reply to Pindolol (a beta-blocker) can alleviate depression, posted by Hugh on December 11, 2019, at 12:37:41

Pindolol is a potent 5ht1a partial agonist and is also useful in the treatment of OCD.

 

Re: Pindolol (a beta-blocker) can alleviate depression phidippus

Posted by Hugh on December 11, 2019, at 19:36:27

In reply to Re: Pindolol (a beta-blocker) can alleviate depression Hugh, posted by phidippus on December 11, 2019, at 18:53:22

Since you have bipolar 1, I thought you might find this pindolol study interesting:

At the end of the acute treatment (day 10; i.e., four days after the last TSD cycle) 75% of bipolar depressed patients treated with coadministration of pindolol and TSD (versus 15% of patients treated with placebo and TSD) showed a complete response. One week after 70% and 5% of patients respectively were still rated as responders.

These data confirming the presence of a positive interaction between pindolol and TSD are in agreement with the hypothesis of a major role of 5-HT neurotransmission in the mechanism of action of TSD.

Complete article:

https://www.nature.com/articles/1395312

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by Lamdage22 on December 12, 2019, at 8:59:56

In reply to Re: Pindolol (a beta-blocker) can alleviate depression phidippus, posted by Hugh on December 11, 2019, at 19:36:27

Driving and operating machines? I have OCD triats

 

Re: Pindolol (a beta-blocker) can alleviate depression Lamdage22

Posted by Hugh on December 12, 2019, at 11:38:03

In reply to Re: Pindolol (a beta-blocker) can alleviate depression, posted by Lamdage22 on December 12, 2019, at 8:59:56

I've been on a few different beta-blockers, though never pindolol. I can drive just fine on them.

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by Lamdage22 on December 12, 2019, at 12:44:57

In reply to Re: Pindolol (a beta-blocker) can alleviate depression Lamdage22, posted by Hugh on December 12, 2019, at 11:38:03

Cool. Thanks. I will add this to my list of things that I haven't tried yet. There is almost always something you can do to get better. That's the beautiful thing. It just needs to be safe

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by linkadge on December 12, 2019, at 15:10:28

In reply to Re: Pindolol (a beta-blocker) can alleviate depression Hugh, posted by phidippus on December 11, 2019, at 18:53:22

I was under the impression that pindolol was a 5-ht1a autoreceptor antagonist, which would increase serotonin release.

Linkadge

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by Hugh on December 13, 2019, at 20:40:18

In reply to Re: Pindolol (a beta-blocker) can alleviate depression, posted by linkadge on December 12, 2019, at 15:10:28

The authors surmise that the delayed effect of SSRIs results from an initial decreased firing rate of 5-HT neurons, caused by excess serotonin stimulating their cell body autoreceptors which exert negative feedback control on the neurons' firing activity. By blocking these autoreceptors, pindolol should accelerate the antidepressant effect of SSRIs.

In the first study, seven of nine untreated patients who received paroxetine with pindolol experienced a 50% decrease in depressive symptoms after one week. In the second study, 10 of 19 drug-resistant patients had a 50% decrease in depressive symptoms after one week of pindolol in addition to paroxetine, fluoxetine, or moclobemide. Interestingly, patients treated with sertraline failed to respond to pindolol augmentation. In both studies, the therapeutic effect of pindolol was maintained for at least 28 days of treatment.

Complete article:

https://www.jwatch.org/jp199509010000007/1995/09/01/pindolol-augmentation-major-depression

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by Hugh on December 14, 2019, at 16:01:29

In reply to Pindolol (a beta-blocker) can alleviate depression, posted by Hugh on December 11, 2019, at 12:37:41

This is a new study about pindolol:

December 11, 2019

Blood pressure drug could help problem drinkers

by Queensland University of Technology

A drug used to treat high blood pressure may alleviate anxiety induced by long-term heavy alcohol use, and also halt the damage such drinking can cause to the brain's ability to grow new cells, QUT research shows.

The findings, from a study conducted in adult mice, have been published in the journal Frontiers in Behavioral Neuroscience.

Principal investigator and QUT neuroscientist, Professor Selena Bartlett, said the results add further evidence that the drug, pindolol, could be beneficial in treating alcohol use disorders.

"This is a drug that is inexpensive and already available in the US, Canada, Europe, and Australia," she said. "It's a beta-blocker that is prescribed for high blood pressure, angina and heart arrhythmias.

"We have been studying it for a number of years and have already shown in animal models that it reduces alcohol intake when there is long-term consumption.

"In this latest study, we investigated the drug's effect on other alcohol associated issues--anxiety and neurogenesis.

"Long-term and heavy drinking can cause anxiety disorders, and people's anxiety can worsen when alcohol is withdrawn, and alcohol abuse can also reduce neurogenesis, which is the process by which new neurons (cells) are formed in the brain.

"We showed that pindolol reduced alcohol-associated anxiety-like behavior in mice and also alleviated the damaging effects of alcohol consumption on newly formed and immature brain cells."

Professor Bartlett said repurposing drugs like pindolol was a way to fast-track new treatments to manage alcohol dependence, binge-drinking and addiction, which are significant and complex problems both in Australia and globally.

The costs to society of alcohol-related problems in Australia in 2010 was estimated at more than $14 billion, including costs to the health system and lost productivity.

"The next step is to conduct clinical trials with pindolol and we have started discussions with a medical specialist to progress that," Professor Bartlett said.

More information: Omkar L. Patkar et al. Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice, Frontiers in Behavioral Neuroscience (2019). DOI: 10.3389/fnbeh.2019.00264

https://medicalxpress.com/news/2019-12-blood-pressure-drug-problem-drinkers.html

 

Despite evidence + availability ... never used??

Posted by linkadge on December 16, 2019, at 9:00:25

In reply to Re: Pindolol (a beta-blocker) can alleviate depression, posted by Hugh on December 14, 2019, at 16:01:29

Despite evidence that this drug can help TRD and the availability / low cost of the drug, I have never heard of patents using pindolol for TRD.

Perhaps this is something we need to push for.

Linkadge

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by undopaminergic on January 8, 2020, at 2:58:14

In reply to Re: Pindolol (a beta-blocker) can alleviate depression Hugh, posted by phidippus on December 11, 2019, at 18:53:22

> Pindolol is a potent 5ht1a partial agonist and is also useful in the treatment of OCD.
>

Antagonist actually. It is thought to disinhibit serotonin release by blocking serotonergic autoreceptors located presynaptically. Usually with autoreceptor antagonists, the dose must be kept low, to avoid also blocking postsynaptic receptors.

-undopaminergic

 

Re: Pindolol (a beta-blocker) can alleviate depression

Posted by Hugh on March 4, 2020, at 11:44:04

In reply to Re: Pindolol (a beta-blocker) can alleviate depression, posted by undopaminergic on January 8, 2020, at 2:58:14

It appears that the ideal dosage for treating depression and anxiety and alcoholism is 7.5 mg. Some suggest that if this doesn't help, you should try 10 mg or 12.5 mg. This is still well below the maximum daily dosage of 60 mg.

> > Pindolol is a potent 5ht1a partial agonist and is also useful in the treatment of OCD.
> >
>
> Antagonist actually. It is thought to disinhibit serotonin release by blocking serotonergic autoreceptors located presynaptically. Usually with autoreceptor antagonists, the dose must be kept low, to avoid also blocking postsynaptic receptors.
>
> -undopaminergic
>


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