Psycho-Babble Medication Thread 1106713

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safely decreasing kynurenicacid w/o cell toxicity?

Posted by cadburyhesychasm on November 6, 2019, at 1:45:51

anyone who has researched this please tell me about it. perhaps amimo acids are involved. i dont know of available kat ii inhibitors

 

Re: safely decreasing kynurenicacid w/o cell toxicity?

Posted by linkadge on November 9, 2019, at 8:25:57

In reply to safely decreasing kynurenicacid w/o cell toxicity?, posted by cadburyhesychasm on November 6, 2019, at 1:45:51

YES. This is something that I have researched.

There is an enzyme called indoleamine 2,3-dioxygenase (IDO) which is responsible for tryptophan metabolism. If this enzyme's levels are high, more tryptophan is converted to kynurenic acid, which can contribute to psychiatric issues. By inhibiting IDO, more tryptophan gets converted to serotonin.

This enzyme may play a (large?) role in how serotonin levels drop in psychiatric disorders. Stress tends to activate IDO.

So the solution? (no expert here but...) there are substances which inhibit IDO activation. Some examples include ginger root, rosmarinc acid, and marijuanna (both CBD and THC inhibit IDO).

There are like others. If you google "inhibits 2,3-dioxygenase" you might get some leads. Inhibiting IDO may also have a positive impact on certain cancers.

Linkadge

 

Re: safely decreasing kynurenicacid w/o cell toxicity?

Posted by Lamdage22 on November 9, 2019, at 13:47:12

In reply to Re: safely decreasing kynurenicacid w/o cell toxicity?, posted by linkadge on November 9, 2019, at 8:25:57

Is Rosmarin contraindicated with psychmeds? Does it inhibit or induce any cytochromep450 enzymes? I am interested in this. I have heard of Rosmarin against depression before.

 

Re: safely decreasing kynurenicacid w/o cell toxicity?

Posted by linkadge on November 10, 2019, at 14:47:47

In reply to Re: safely decreasing kynurenicacid w/o cell toxicity?, posted by Lamdage22 on November 9, 2019, at 13:47:12

Is rosmarin the same as rosmarinic acid?

I grow rosemary and use it for anxiety. You can pick off the needles and chew on them. Rosmarinic acid does have antidepressant properties (at least in animal models). It also inhibits gaba-t activity, and has some inhibitor effects on calcium channels.

In some ways, it resembles valproate. I don't know about interactions with liver enzymes.

Linkadge

 

Anxiety cuz Venlafaxine is wearing off?

Posted by Lamdage22 on November 11, 2019, at 9:52:47

In reply to Re: safely decreasing kynurenicacid w/o cell toxicity?, posted by linkadge on November 10, 2019, at 14:47:47

Unfortunately, it does interact. Gaba-t inhibition is awesome for social anxiety!

 

Test (nm)

Posted by Lamdage22 on November 11, 2019, at 9:56:35

In reply to Anxiety cuz Venlafaxine is wearing off?, posted by Lamdage22 on November 11, 2019, at 9:52:47

 

Re: Anxiety cuz Venlafaxine is wearing off?

Posted by sigismund on December 7, 2019, at 20:04:38

In reply to Anxiety cuz Venlafaxine is wearing off?, posted by Lamdage22 on November 11, 2019, at 9:52:47

Lemon balm contains rosmarinic acid, IIRC.


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