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Dr. Bob is Robert Hsiung, MD,
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Posted by radish on August 24, 2019, at 20:34:08
Does body weight or biological sex influence the pharmacokinetics and pharmacodynamics of psychotropic drugs? Would a given dose have different concentrations in lower and higher body weight individuals? I am interested in this topic but did not find straightforward answers online. Does anyone have any info?
Radish
Posted by TH on August 25, 2019, at 7:10:40
In reply to Does body weight influence psych med concentration, posted by radish on August 24, 2019, at 20:34:08
The answer is yes, body weight would have an effect. Medication dose is sometimes given as mg/Kg for this reason (milligrams of substance per kg of body weight)
That being said, very rarely are we precise enough with with our dosing for +/- a few % in mg/Kg dose to be of much consequence.
Posted by linkadge on August 25, 2019, at 11:05:54
In reply to Re: Does body weight influence psych med concentration, posted by TH on August 25, 2019, at 7:10:40
A big factor (probably bigger than weight) is genetic differences in liver enzymes. This can have a difference on level of drug and/or active metabolites.
Really, unless one is using therapeutic monitoring (say Depakote, lithium or nortriptyline) the dose should not be a specific target IMHO. Some people do well on low doses, some need higher doses.
Linkadge
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