Psycho-Babble Medication Thread 1097498

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CRP Predicts Response to Antidepressants

Posted by SLS on March 19, 2018, at 7:27:40

C-Reactive Protein (CRP) Predicts Response to Antidepressants.

CRP is a biomarker for systemic inflammation. Inflammation is associated with depression.

A few studies found that:

1. High CRP indicates a reduced rate of response to antidepressants.
2. High CRP predicts a better response to nortriptyline (Pamelor) than to escitalopram (Lexapro).
3. High CRP predicts a better response to SSRI + Wellbutrin than to SSRI monotherapy.

Has anyone used a CRP blood test to choose an antidepressant?

I would like to know how SNRIs rate with respect to CRP levels in comparison to SSRIs.

- Scott

Re: CRP Predicts Response to Antidepressants

Posted by linkadge on March 19, 2018, at 10:31:25

In reply to CRP Predicts Response to Antidepressants, posted by SLS on March 19, 2018, at 7:27:40

Hey SLS,

It appears that some kind of noradrenergic action is required for response to high CRP depression.

I switched back from nortriptyline to mirtazapine.

I felt that the nortriptyline was helping my depression more than mirtazapine, but my sleep was becoming very fragmented. Also, the higher heart rate was starting to bother me.

I don't think that mirtazapine has the positve effect on inflamation that nortripypline does. I think venlafaxine has some anti-inflamatory effect.

Linkadge

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