Psycho-Babble Medication Thread 1097033

Shown: posts 1 to 15 of 15. This is the beginning of the thread.

 

Antidepressant Pipeline Page

Posted by Peter S on February 21, 2018, at 13:48:28

Hi all,

Here is link to a great list of all current antidepressant clinical trials:

https://mentalhealthdaily.com/2018/02/13/new-antidepressants-2018-drugs-in-clinical-trials/

 

Re: Antidepressant Pipeline Page

Posted by SLS on February 21, 2018, at 15:19:48

In reply to Antidepressant Pipeline Page, posted by Peter S on February 21, 2018, at 13:48:28

> Hi all,
>
> Here is link to a great list of all current antidepressant clinical trials:
>
> https://mentalhealthdaily.com/2018/02/13/new-antidepressants-2018-drugs-in-clinical-trials/
>


Thanks.


- Scott

 

Re: Antidepressant Pipeline Page

Posted by linkadge on February 21, 2018, at 15:55:03

In reply to Re: Antidepressant Pipeline Page, posted by SLS on February 21, 2018, at 15:19:48

Unfortunately, that pipeline is a lot slower for people with no insurance coverage.

I looked up vilazodone in Canada, and we're talking close to $400 a month.

Linkadge

 

Re: Antidepressant Pipeline Page linkadge

Posted by SLS on February 21, 2018, at 20:24:23

In reply to Re: Antidepressant Pipeline Page, posted by linkadge on February 21, 2018, at 15:55:03

> Unfortunately, that pipeline is a lot slower for people with no insurance coverage.
>
> I looked up vilazodone in Canada, and we're talking close to $400 a month.

I'm sorry to hear that. There are no bargains out there unless you are taking lithium or nortriptyline. I wish things were simpler for you.

By the way, how often during the day do you take lithium?


- Scott

 

Re: Antidepressant Pipeline Page SLS

Posted by Phillipa on February 22, 2018, at 11:26:19

In reply to Re: Antidepressant Pipeline Page linkadge, posted by SLS on February 21, 2018, at 20:24:23

Scott in case Link doesn't see this he did state how often he takes lithium. I copied and pasted his reply to an earlier thread. Phillipa


Hey SLS,

I take 300mg lithium once a day. My mother has taken 600-900mg once a day for 35 years with some mild signs of kidney impairment.

Lithium apparently accumulates in the brain. In the short term, steady blood levels may be required, but I think over time, it may not be as important (?).

Mind you, I am using it mainly for depression.

Interestingly, since starting, I rarely need additional medications.

I take 300m as well as omega-3 and, in general, am doing fine.

Linkadge

 

Re: Antidepressant Pipeline Page Phillipa

Posted by SLS on February 22, 2018, at 16:08:27

In reply to Re: Antidepressant Pipeline Page SLS, posted by Phillipa on February 22, 2018, at 11:26:19

Thanks, Phillipa.

I had forgotten about this. Forgetting things is a hobby of mine.


> Scott in case Link doesn't see this he did state how often he takes lithium. I copied and pasted his reply to an earlier thread. Phillipa
>
>
> Hey SLS,
>
> I take 300mg lithium once a day. My mother has taken 600-900mg once a day for 35 years with some mild signs of kidney impairment.
>
> Lithium apparently accumulates in the brain. In the short term, steady blood levels may be required, but I think over time, it may not be as important (?).
>
> Mind you, I am using it mainly for depression.
>
> Interestingly, since starting, I rarely need additional medications.
>
> I take 300m as well as omega-3 and, in general, am doing fine.
>
> Linkadge

 

Re: Antidepressant Pipeline Page SLS

Posted by Phillipa on February 22, 2018, at 19:01:56

In reply to Re: Antidepressant Pipeline Page Phillipa, posted by SLS on February 22, 2018, at 16:08:27

Knew you were having a hard time trying to be helpful. Phillipa

 

Re: Antidepressant Pipeline Page SLS

Posted by linkadge on February 23, 2018, at 15:50:42

In reply to Re: Antidepressant Pipeline Page linkadge, posted by SLS on February 21, 2018, at 20:24:23

I just take 300mg once a day (for lithium).

Linkadge

 

Re: Antidepressant Pipeline Page Phillipa

Posted by ed_uk2010 on February 26, 2018, at 19:46:31

In reply to Re: Antidepressant Pipeline Page SLS, posted by Phillipa on February 22, 2018, at 19:01:56

PJ,

So nice to see your name again.

Another thing...

You know, one thing I like about this forum is the consistency. It may not be modern, but it has a very reassuring familiarity.

Ed

 

Re: Antidepressant Pipeline Page ed_uk2010

Posted by Phillipa on February 26, 2018, at 22:17:10

In reply to Re: Antidepressant Pipeline Page Phillipa, posted by ed_uk2010 on February 26, 2018, at 19:46:31

Ed wow what is new with you? PJ xxx

 

Re: Antidepressant Pipeline Page

Posted by baseball55 on February 27, 2018, at 19:17:20

In reply to Antidepressant Pipeline Page, posted by Peter S on February 21, 2018, at 13:48:28

The NPR show Fresh Air had an interview today with Lauren Slater, author of a book called Blue Dreams about psychotropic drugs. She said there have been a lot a promising success (mostly in Europe and Canada where restrictions on research are not as great) with low-dose LSD and psylocibin for PTSD, depression and end-of-life anxiety. Sounds like a very interesting book.

 

Re: Antidepressant Pipeline Page

Posted by Lamdage22 on March 6, 2018, at 12:27:08

In reply to Re: Antidepressant Pipeline Page ed_uk2010, posted by Phillipa on February 26, 2018, at 22:17:10

I have moved from approx. 100mg Lithium to 200mg. Hoping to get some more of that BDNF

 

Re: Antidepressant Pipeline Page

Posted by bleauberry on March 9, 2018, at 11:17:29

In reply to Antidepressant Pipeline Page, posted by Peter S on February 21, 2018, at 13:48:28

I think it makes more sense to take action NOW instead of waiting. People who do that get better a lot faster than those who don't. In my case it took 20 years of failed psychiatrists and a backpack full of failed prescriptions before I realized I was on the wrong road. I eventually beat my treatment resistant major depression by treating it as Lyme disease instead. That's because my doctors told me that 9 out of 10 psychiatric patients poorly managed by drugs actually have an unsuspected steal infection instead. It sounded absolutely ridiculous the first time I heard that. But I acted on it because I had exhausted every other thing coming down 'the pipeline'.

And I got better. I had 2 years of remission, a 6 month relapse, currently treating again, some minor issues but depression is not one of them.

Lest anybody think, yeah, well, that's rare, that's just you, that doesn't happen very often - no that is all wrong - it happens a lot - it happens to literally millions of people - they get psychiatrically better when they treat it as something else other than a chemical imbalance - they go after the cause of the chemical imbalance - which is 9 out of 10 caused by an infection, toxins, and inflammation, all tied together to totally disrupt your nervous system and brain in ways impossible for any man-made substance to address.

 

Re: Antidepressant Pipeline Page bleauberry

Posted by Tony P on March 28, 2018, at 1:17:38

In reply to Re: Antidepressant Pipeline Page, posted by bleauberry on March 9, 2018, at 11:17:29

Interesting thoughts. To your list of "infection, toxins, and inflammation" I would add: addictive substances, and behaviours that are short-run relief but long-term trouble. I believe I've heard of some antibiotics relieving depression. I am sure that behaviour, and perhaps treating infection is a sort of behaviour, modifies brain chemistry just as much as changing brain chemistry modifies behaviour. The question is, where to start? Or which is easier? As Alan Watts said, "Do You Do It, or Does It Do You?"....

 

Re: Antidepressant Pipeline Page Tony P

Posted by SLS on March 28, 2018, at 8:26:59

In reply to Re: Antidepressant Pipeline Page bleauberry, posted by Tony P on March 28, 2018, at 1:17:38

> Interesting thoughts. To your list of "infection, toxins, and inflammation" I would add: addictive substances, and behaviours that are short-run relief but long-term trouble. I believe I've heard of some antibiotics relieving depression. I am sure that behaviour, and perhaps treating infection is a sort of behaviour, modifies brain chemistry just as much as changing brain chemistry modifies behaviour. The question is, where to start? Or which is easier? As Alan Watts said, "Do You Do It, or Does It Do You?"....

Regarding antibiotics, another possibility is that it helps to reset gut flora. There seems to be a very strong connection between bacteria in the GI tract and brain function - and vice-versa. There need not be an infection. I wouldn't know which antibiotics are effective for this purpose. I guess one would want to take pro-biotics to re-establish the good critters while vanquishing the bad ones.

I like to mention minocycline because it penetrates the brain efficiently and acts to reduce inlammation while modulating glutamate activity. The only two people I know who tried minocycline for depression felt significantly improved within a few days. One would think that if the antibiotic action of minocycline were to be involved, it would have taken longer. The improvement persisted. Doxycycline had no effect on me after 3 months, but minocycline helped after 3 days. Unfortunately, a long-term side effect of minocycline is hyperpigmentation that usually manifests as dark black and blue discolorations on the feet and shins. It can take as long as 1.5 years to develop this if you were to take minocycline every day.

An idea just occurred to me. If minocycline helps within a few days, you might be a responder to its glutakate modulating effects. You could then add lamotrigine (Lamictal), possibly combined with NAC (N-acetylcysteine), and try discontinuing the minocycline after three weeks or so. It almost makes sense to try minocycline before going with doxycycline. It is unlikely that minocycline would produce hyperpigmentation during a short course of treatment. So, if minocycline does not produce a rapid response, and you feel the need to be on an antibiotic long-term, you could then switch to doxycyline. Both minocycline and doxycycline reduce brain inflammation. So do antidepressants when they work.

Don't forget to take pro-biotics to repopulate the gut with a healthy flora.


- Scott


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