Psycho-Babble Medication Thread 1097137

Shown: posts 1 to 21 of 21. This is the beginning of the thread.

 

Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by farshad on March 3, 2018, at 4:35:16

According to this Wikipedia page: https://en.wikipedia.org/wiki/Dopamine_reuptake_inhibitor
Scroll down to List of DRIs.
It says Modafinil (relatively weak but very selective for the dopamine transporter). What does that mean very selective? is it weak or not? according to the Modafinil own page it says at 300mg Modafinil inhibits 50% dopamine transporters, thats not weak. so can someone explain?

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by Lamdage22 on March 3, 2018, at 11:04:51

In reply to Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 4:35:16

You always come up with new questions regarding mechanisms of action. But even scientists dont know why certain drugs are working and others are not. This is not a clear cut science yet that you can learn and then make some sort of super smart decision.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by farshad on March 3, 2018, at 11:17:08

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by Lamdage22 on March 3, 2018, at 11:04:51

> You always come up with new questions regarding mechanisms of action. But even scientists dont know why certain drugs are working and others are not. This is not a clear cut science yet that you can learn and then make some sort of super smart decision.
>
>
Are u blind? im just asking for the mechanism of action . all drugs have an mechanism that they work on that we follow. Thats how we can find out which drugs suits said person. We dont give dopamine agonist to schizoprenia patients.. Stop putting words in my mouth and wasting my time with ur SH*t talk. I just wanna know why its labeled weak when it inhibits 50% which is not weak.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by Lamdage22 on March 3, 2018, at 11:20:56

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by Lamdage22 on March 3, 2018, at 11:04:51

if you have social anxiety then Nardil or Marplan would be what people would recommend here. I dont because in my case it was pretty harmful (psychosis)

You have to make up your own mind. If you try something watch out for worsening or emergence of new psychotic smyptoms.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by Lamdage22 on March 3, 2018, at 11:24:12

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 11:17:08

but many drugs have more than one mechanism of action

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad

Posted by SLS on March 3, 2018, at 11:30:49

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 11:17:08

> > You always come up with new questions regarding mechanisms of action. But even scientists dont know why certain drugs are working and others are not. This is not a clear cut science yet that you can learn and then make some sort of super smart decision.
> >
> >
> Are u blind? im just asking for the mechanism of action . all drugs have an mechanism that they work on that we follow. Thats how we can find out which drugs suits said person. We dont give dopamine agonist to schizoprenia patients.. Stop putting words in my mouth and wasting my time with ur SH*t talk. I just wanna know why its labeled weak when it inhibits 50% which is not weak.

Lamdage makes a good point. The brain is in many ways still a black box to us. I can't blame you for wanting to choose a drug that will be the best fit for you. However, people are often surprised as to what works for them and what makes them worse. You may have to move forward and choose a drug based upon a clinical profile rather than a molecular one.

Is there any one drug that interests you most? If it were necessary for you to choose a drug today, which one would it be?


- Scott

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by farshad on March 3, 2018, at 11:32:37

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad, posted by SLS on March 3, 2018, at 11:30:49

> > > You always come up with new questions regarding mechanisms of action. But even scientists dont know why certain drugs are working and others are not. This is not a clear cut science yet that you can learn and then make some sort of super smart decision.
> > >
> > >
> > Are u blind? im just asking for the mechanism of action . all drugs have an mechanism that they work on that we follow. Thats how we can find out which drugs suits said person. We dont give dopamine agonist to schizoprenia patients.. Stop putting words in my mouth and wasting my time with ur SH*t talk. I just wanna know why its labeled weak when it inhibits 50% which is not weak.
>
> Lamdage makes a good point. The brain is in many ways still a black box to us. I can't blame you for wanting to choose a drug that will be the best fit for you. However, people are often surprised as to what works for them and what makes them worse. You may have to move forward and choose a drug based upon a clinical profile rather than a molecular one.
>
> Is there any one drug that interests you most? If it were necessary for you to choose a drug today, which one would it be?
>
>
> - Scott
>
>

where are we going with this conversation? all im asking is why is Modafinil labeled weak Dopamine inhibitor on that wikipedia page when it inhibits 50% dopamine transporter at 300mg .

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by Lamdage22 on March 3, 2018, at 12:22:27

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad, posted by SLS on March 3, 2018, at 11:30:49

one ssri makes me better, the other one suicidal. Explain that!
If it was that easy everyone would invent their own drug.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by farshad on March 3, 2018, at 12:36:56

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by Lamdage22 on March 3, 2018, at 12:22:27

> one ssri makes me better, the other one suicidal. Explain that!
> If it was that easy everyone would invent their own drug.

because ur a Placebo Mess . All SSRI do increase serotonin but they also do other things which differ from each ssri.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad

Posted by ed_uk2010 on March 3, 2018, at 16:01:03

In reply to Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 4:35:16

>according to the Modafinil own page it says at 300mg Modafinil inhibits 50% dopamine transporters, thats not weak.

It could be weak according to the clinical effects exerted; even though 50% 'sounds' like a decent percentage, it may not be.

If you look at SSRIs for example, a dose which blocks 50% of transporters is not clinically effective. The dosages used in practice block a much higher percentage of transporters.

The same sort of situation applies to antipsychotics when used in psychosis. Blocking 50% of dopamine D2 sites does not appear useful. Therapeutic doses of most antipsychotics block a much higher percentage.


 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad

Posted by SLS on March 4, 2018, at 1:14:07

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 11:32:37

Modafinil does a few different things, but much of what is written points to DRI as being responsible for its wake-promoting effects. However, orexin might be involved.

Is there any one drug that interests you most? If it were necessary for you to choose a drug today, which one would it be?


- Scott

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by Lamdage22 on March 4, 2018, at 4:59:26

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor? farshad, posted by SLS on March 4, 2018, at 1:14:07

some dopamine in the right parts of the brain is a good thing even in schizophrenia.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by Lamdage22 on March 4, 2018, at 11:49:26

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by Lamdage22 on March 4, 2018, at 4:59:26

what symptoms are you doing the mechanism of action research for? What is your goal?

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by linkadge on March 4, 2018, at 12:55:43

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 11:17:08

>Stop putting words in my mouth and wasting my >time with ur SH*t talk. I just wanna know why >its labeled weak when it inhibits 50% which is >not weak.

If you ask people for their knowledge, they're going to share their knowledge!! If you just want information, then go to Wikipedia or google! Part of the knowledge (and more importantly wisdom) you will gain here (if you stick around long enough) is the understanding (that I personally gained over two decades of living with mental illness) is that the mechanism of a drug gives a **very limited** indication of the efficacy of the drug for a particular individual.

Drugs that look good on paper often do *not* translate well to the efficacy of that drug for a particular individual. If you want information, go to google. If you want wisdom then have some respect and listen to what people are saying.

Treat your disorder based on what the symptoms are, not what you believe the underlying cause to be. Scientists are only barely scratching the surface when it comes to how these drugs work.

Neurotransmitter deficiency was a theory that is decades old. Modern theories are much, much, much more comprehensive and complicated (since the brain is extraordinarily complicated).

The drugs are likely acting on a level that we haven't fully elucidated. This includes brain growth factors, neuroprotection, inflammation, intercellular / intracellular actions, gene modification, HPA axis, circadian rythm, protein synthesis, the list goes on...

If you think this is about high or low serotonin, you are still thinking the earth is flat.


Linkadge

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor? linkadge

Posted by ed_uk2010 on March 4, 2018, at 14:44:25

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by linkadge on March 4, 2018, at 12:55:43

What an excellent, well-written post Linkadge.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by PeterMartin on March 5, 2018, at 11:55:30

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by linkadge on March 4, 2018, at 12:55:43

Wow all you guys who responded kindly I commend you.

https://www.quora.com is a place to get knowledge based questions. This is a discussion forum. As is socialanxeitysupport where I think I've seen similar requests for science only answers.

No need to be rude - c'mon. We are all here to help one another. There are tons of places on the internet to find more expert answers to the question. People come here to discuss and support.

If it matters:

I take Nuvigil. I want off of it. Supposed to keep you awake but makes me scatterbrained and sleepy. It's more difficult to quit than I'd like though. I know I just need a few days off it to get over the w/d but I keep having on that.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by PeterMartin on March 5, 2018, at 11:58:47

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by PeterMartin on March 5, 2018, at 11:55:30

I meant to say"caving" not having.

Medschat is another site better suited for a direct question like this one as well:

https://www.medschat.com

Or go scholar:

Http://scholar.google.com

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by PeterMartin on March 5, 2018, at 12:02:14

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by PeterMartin on March 5, 2018, at 11:58:47

Simple scholar.google.com search for "modafinil dopamine" gives this first result.


Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications


All ya need is love.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor? PeterMartin

Posted by ed_uk2010 on March 5, 2018, at 17:37:45

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by PeterMartin on March 5, 2018, at 12:02:14

>Simple scholar.google.com search for "modafinil dopamine" gives this first result.

Great search engine, thanks.

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor? PeterMartin

Posted by beckett2 on March 8, 2018, at 22:38:57

In reply to Re: Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by PeterMartin on March 5, 2018, at 11:58:47

Medschat looks interesting. Thanks!

> I meant to say"caving" not having.
>
> Medschat is another site better suited for a direct question like this one as well:
>
> https://www.medschat.com
>
> Or go scholar:
>
> Http://scholar.google.com

 

Re: Is Modafinil a Weak Dopamine reuptake inhibitor?

Posted by bleauberry on March 9, 2018, at 11:08:55

In reply to Is Modafinil a Weak Dopamine reuptake inhibitor?, posted by farshad on March 3, 2018, at 4:35:16

All I know about Modafinil is that when I added it to my ongoing Prozac+Zyprexa combo, it was like being reborn. I had several years of productive life, better than other drugs, before it pooped out. Even better than Modafinil though is its precursor Adrafanil which is available mail order online. I think Adrafinil by itself is maybe one of the best antidepressants in the world and hardly anybody has ever heard of it.


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