Psycho-Babble Medication Thread 1096915

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Once daily lithium?

Posted by SLS on February 8, 2018, at 13:42:55

I'm curious as to how people take their lithium. I have always taken simple lithium carbonate (not slow-release) twice a day.

There are a whole bunch of articles describing the benefits of once-daily dosing of lithium taken at night. The most compelling finding is that this dosing schedule results in less renal impairment. The explanation given is that the kidneys need time during the day for which the level of lithium in the blood drops low enough for them to repair themselves. Once-a-day dosing allows for a lower trough blood level for a longer period of time than divided dosing.

Google:

https://www.google.com/search?&q=lithium+once+daily+dosing+renal+kidney


- Scott

 

Re: Once daily lithium?

Posted by linkadge on February 9, 2018, at 17:45:35

In reply to Once daily lithium?, posted by SLS on February 8, 2018, at 13:42:55

Hey SLS,

I take 300mg lithium once a day. My mother has taken 600-900mg once a day for 35 years with some mild signs of kidney impairment.

Lithium apparently accumulates in the brain. In the short term, steady blood levels may be required, but I think over time, it may not be as important (?).

Mind you, I am using it mainly for depression.

Interestingly, since starting, I rarely need additional medications.

I take 300m as well as omega-3 and, in general, am doing fine.

Linkadge

 

Re: Once daily lithium?

Posted by linkadge on February 9, 2018, at 17:50:15

In reply to Re: Once daily lithium?, posted by linkadge on February 9, 2018, at 17:45:35

I read an article on pubmed (will look for it), in which supplemental zinc, reduced the renal effects of lithium in an animal model.

Linkadge


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