Psycho-Babble Medication Thread 1095540

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Add zoloft to clomipramine

Posted by chrismeurer on October 22, 2017, at 14:39:15

Hi, could adding zoloft 50 mg to clomipramine 100 mg be safe? I was thinking about SERT occupancy and sent a message to my doctor asking if the action of clomipramine and zoloft together could produce enough occupancy of SERT thus leading to increased DAT occupancy by zoloft. What do you think? I just started zoloft 50 mg, and take 100 mg clomipramine, 10 mg abilify and 15 mg buspirone.

Thank you.


Re: Add zoloft to clomipramine

Posted by linkadge on October 25, 2017, at 16:28:25

In reply to Add zoloft to clomipramine, posted by chrismeurer on October 22, 2017, at 14:39:15

I haven't heard of serotonin syndrome from the combination of serotonin reuptake inhibitors.

In theory, what you say makes sense. If the serotonin transporter is fully saturated, then Zoloft might begin to bind more to its secondary site (dopamine). Alternatively, clomipramine might also begin to bind more to it's secondary sites (norepinephrine, 5-ht2a, histamine etc).


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