Psycho-Babble Medication Thread 1095036

Shown: posts 1 to 16 of 16. This is the beginning of the thread.

 

Emsam + other meds

Posted by pedr on September 17, 2017, at 17:12:12

I know that anything serotonergic is a no-no but what about Bupropion and abilify? Does the dose of emsam matter (i.e. <9mg or not)?
Thanks.

 

Re: Emsam + other meds

Posted by linkadge on September 17, 2017, at 19:01:28

In reply to Emsam + other meds, posted by pedr on September 17, 2017, at 17:12:12

Depending on the dose, I have heard of selegiline being used with SSRIs.

I wouldn't think selegiline with abilify would be an issue. However, selegiline with bupropion could.

The issue with selegiline and bupropion would be excessive dopaminergic stimulation. Basically, you are shutting down two metabolic pathways for dopamine (MAO-B and DAT) so excessive stimulation and possible psychotic reactions could be possible.

Again, the interaction could be dose dependent. If you were to combine the two, I would very cautiously combine one with the other.

Linkadge

 

Re: Emsam + other meds linkadge

Posted by pedr on September 19, 2017, at 9:03:25

In reply to Re: Emsam + other meds, posted by linkadge on September 17, 2017, at 19:01:28

> Depending on the dose, I have heard of selegiline being used with SSRIs.
>
> I wouldn't think selegiline with abilify would be an issue. However, selegiline with bupropion could.
>
> The issue with selegiline and bupropion would be excessive dopaminergic stimulation. Basically, you are shutting down two metabolic pathways for dopamine (MAO-B and DAT) so excessive stimulation and possible psychotic reactions could be possible.
>
> Again, the interaction could be dose dependent. If you were to combine the two, I would very cautiously combine one with the other.
>
> Linkadge

Thanks Linkadge. I've read that SRI's are the ones to avoid for MAOI's (mostly from the excellent psychotropical.com) but that's good to know about bupropion. TBH I wouldn't miss it that much, I'm not sure what benefit it gives me (as with most of my meds sadly).

My PDoc is very cautious around MAOI's so I suspect he's not going to allow me to take anything anyway. I just wanted to see what people's experience with this was.

 

Re: Emsam + other meds

Posted by linkadge on September 19, 2017, at 10:26:51

In reply to Re: Emsam + other meds linkadge, posted by pedr on September 19, 2017, at 9:03:25

That is a good approach (i.e. no other meds when taking an MAOI)

That being said, Selegiline is more selective towards MAO-B. MAO-B primarily affects dopamine.

In higher doses (as used for depression) it starts to affect MAO-A as well (which elevates serotonin).

There are a number of reports of Parkinson's patients taking an SSRI and selegiline. However, they were likely taking lower (MAO-B selective) doses of selegiline.

Wellbutrin probably could be combined with Selegiline but would have to be introduced extremely gradually, just to watch for overstimulation.

Linkadge


 

Re: Emsam + other meds

Posted by Pontormo on September 20, 2017, at 6:02:58

In reply to Re: Emsam + other meds, posted by linkadge on September 19, 2017, at 10:26:51

Abilify is ok to combine with Emsam. I use a small dose and it seems to help--

 

Re: Emsam + other meds Pontormo

Posted by pedr on September 20, 2017, at 10:02:46

In reply to Re: Emsam + other meds, posted by Pontormo on September 20, 2017, at 6:02:58

> Abilify is ok to combine with Emsam. I use a small dose and it seems to help--

great, good to know. I take just 2.5mg. Anything higher makes me more depressed.

 

Re: Emsam + other meds

Posted by chumbawumba on September 21, 2017, at 1:05:24

In reply to Emsam + other meds, posted by pedr on September 17, 2017, at 17:12:12

I'm a big fan of low dose Lithium. For me anyway it makes everything work better.

 

Re: Emsam + other meds

Posted by Pontormo on September 21, 2017, at 9:31:32

In reply to Re: Emsam + other meds Pontormo, posted by pedr on September 20, 2017, at 10:02:46

That's about the dose I use, although sometimes I use a little less, just on the theory that less (if it's effective) is more.

Pontormo

 

Re: Emsam + other meds chumbawumba

Posted by pedr on September 21, 2017, at 9:51:37

In reply to Re: Emsam + other meds, posted by chumbawumba on September 21, 2017, at 1:05:24

> I'm a big fan of low dose Lithium. For me anyway it makes everything work better.
>

I wish Lithium liked me. I tried very low dose Lithium Orotate and it put me in an incapacitating depression pretty quickly.

 

Re: Emsam + other meds pedr

Posted by beckett2 on September 21, 2017, at 17:22:28

In reply to Re: Emsam + other meds chumbawumba, posted by pedr on September 21, 2017, at 9:51:37

I was fine until 12 mg. Then kefir and then coffee became a little sketchy. In addition, and unfortunately, there isn't a decent pain medication to be taken with it-- excluding an opiate. I'd be pretty careful-- sounds like you are. Some here have mixed their meds and know more than I do, but my experience with coffee was sobering :/

But it really did help my depression.

I hope Abilify is helping.

 

Re: Emsam + other meds

Posted by linkadge on September 23, 2017, at 19:48:08

In reply to Re: Emsam + other meds chumbawumba, posted by pedr on September 21, 2017, at 9:51:37

I find lithium carbonate has more antidepressant effects than lithium orotate. Lithium orotate made me somewhat depressed too.

Linkadge

 

Re: Emsam + other meds linkadge

Posted by pedr on September 25, 2017, at 7:38:35

In reply to Re: Emsam + other meds, posted by linkadge on September 23, 2017, at 19:48:08

> I find lithium carbonate has more antidepressant effects than lithium orotate. Lithium orotate made me somewhat depressed too.
>
> Linkadge

wow now that is interesting. I wonder what that's all about? I had such a bad reaction to Orotate that I would be very reticent and scared of trying carbonate.

 

Re: Emsam + other meds

Posted by SLS on September 26, 2017, at 23:06:04

In reply to Re: Emsam + other meds linkadge, posted by pedr on September 25, 2017, at 7:38:35

> > I find lithium carbonate has more antidepressant effects than lithium orotate. Lithium orotate made me somewhat depressed too.
> >
> > Linkadge
>
> wow now that is interesting. I wonder what that's all about? I had such a bad reaction to Orotate that I would be very reticent and scared of trying carbonate.

What was your bad reaction?

I read recently that lithium orotate was harmful while lithium carbonate was helpful. I don't remember the details.


- Scott

 

Re: Emsam + other meds SLS

Posted by pedr on September 27, 2017, at 9:10:41

In reply to Re: Emsam + other meds, posted by SLS on September 26, 2017, at 23:06:04


> What was your bad reaction?

a rapid and intense increase in depression. No other effects that I recall.

 

Re: Emsam + other meds pedr

Posted by SLS on September 27, 2017, at 9:30:21

In reply to Re: Emsam + other meds SLS, posted by pedr on September 27, 2017, at 9:10:41

>
> > What was your bad reaction?
>
> a rapid and intense increase in depression. No other effects that I recall.

Interestingly, the dosages used for bipolar disorder (900-1500 mg/day) make me more depressed while low dosages (300 mg/day) act as a mild-moderate antidepressant. I can't do without it. Two additional benefits include the lengthening of chromosome telomeres and the mitigation of the risk of developing Alzheimer's Dementia.


- Scott

 

Re: Emsam + other meds

Posted by linkadge on September 30, 2017, at 11:22:57

In reply to Re: Emsam + other meds, posted by SLS on September 26, 2017, at 23:06:04

Lithium orotate induced some form of emotional overtone. Its hard to describe, but it felt a bit like combining lithium and choline.

Linkadge


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