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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by farshad on September 9, 2017, at 17:47:15
zyprexa hits most neurotransmitters and blocks them. I don´t know why but when I first took Zyprexa I was 100% anxiety free. Might be because it blocked my Serotonin? No Idea. From what I can tell this is the strongest Serotonin blocker/decreaser. I think I took 2.5mg . I dont wanna go too high of a dosage on it to avoid the Side effects. But yeah Zyprexa for my anxiety.. But Zyprexa also makes me tired so I thought Adding wellbutrin to increase norepinephrine. What about the weight gain? well Wellbutrin is know to decrease weight so I got that covered aswell. And the last abilify to increase dopamine.. Since zyprexa blocks that.
So:
Zyprexa : 2-5mg-5mg Daily
Wellbutrin : 300mg daily
Abilify: 5mg daily.
Posted by phidippus on October 7, 2017, at 17:39:20
In reply to Zyprexa + abilify + wellbutrin combo?, posted by farshad on September 9, 2017, at 17:47:15
Wellbutrin increases dompamine. Abilify is a partial agonist and its effect on it is more complex than increasing it. Drop the Abilify.
Eric
Posted by farshad on October 8, 2017, at 9:23:06
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by phidippus on October 7, 2017, at 17:39:20
> Wellbutrin increases dompamine. Abilify is a partial agonist and its effect on it is more complex than increasing it. Drop the Abilify.
>
> Ericim not gonna drop the abilify ur crazy there is a reason why its most selling drug cus it works . wellbutrin is a weak dopamine agonist not enough to notice any effects look it up. Abilify balances dopamine if thats what you wanna hear .
Posted by phidippus on October 8, 2017, at 10:18:02
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by farshad on October 8, 2017, at 9:23:06
OK, what the hell are you trying to treat?
Eric
Posted by farshad on October 8, 2017, at 10:44:21
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by phidippus on October 8, 2017, at 10:18:02
Well you saw my theory on the serotonin and the amygdala stuff. Anyway I wanna increase my norepehrpine (however u spell that) and dopamine with wellbutrin and abilify. Second instead of zyprexa I wanna try remeron (mirtazapine) which blocks many serotonin receptors and I belive it has some actions on the amygdala help decrease it or something . Many people say remeron helps with their anxiety so im willing to try it anyway instead of zyprexa which did work. Im not sure how zyprexa helped could be because it decreases amygdala or because it Increases Progesterone (progesterone calms you) .
Posted by SLS on October 8, 2017, at 13:39:24
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by phidippus on October 7, 2017, at 17:39:20
Hi, Eric.
I am suspicious that Abilify, at least in some situations, might actually reduce the antipsychotic effects of other neuroleptics, and require dosage escalation of these other drugs. I have seen this happen when Abilify was added to Seroquel.
- Scott
Posted by farshad on October 8, 2017, at 13:46:13
In reply to Re: Zyprexa + abilify + wellbutrin combo? » phidippus, posted by SLS on October 8, 2017, at 13:39:24
> Hi, Eric.
>
> I am suspicious that Abilify, at least in some situations, might actually reduce the antipsychotic effects of other neuroleptics, and require dosage escalation of these other drugs. I have seen this happen when Abilify was added to Seroquel.
>
>
> - Scottwell of course most antipsychotic just block dopamine but abilify actually raises it , so adding abilify to say zyprexa would stop zyprexa from working since people that need antipsychotic have too much dopamine. I think abilify is the only antipsychotic that raises dopamine.
well Im over zyprexa anyway Im shooting for mirtazapine instead since it doesent block dopamine not that I know of.
wellbutrin + abilify + mirtazapine
Posted by phidippus on October 8, 2017, at 13:56:05
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by farshad on October 8, 2017, at 13:46:13
Partial agonists bind to and activate a receptor, but are not able to elicit the maximum possible response that is produced by full agonists. The maximum response produced by a partial agonist is called its intrinsic activity and may be expressed on a percentage scale where a full agonist produced a 100% response. A key property of partial agonists is that they display both agonistic and antagonistic effects. In the presence of a full agonist, a partial agonist will act as an antagonist, competing with the full agonist for the same receptor and thereby reducing the ability of the full agonist to produce its maximum effect. The balance of activity between agonist and antagonist effects varies from one substance to another, according to their intrinsic activities, and is also influenced by the test system used to measure their effects.
Posted by farshad on October 8, 2017, at 14:24:18
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by phidippus on October 8, 2017, at 13:56:05
> Partial agonists bind to and activate a receptor, but are not able to elicit the maximum possible response that is produced by full agonists. The maximum response produced by a partial agonist is called its intrinsic activity and may be expressed on a percentage scale where a full agonist produced a 100% response. A key property of partial agonists is that they display both agonistic and antagonistic effects. In the presence of a full agonist, a partial agonist will act as an antagonist, competing with the full agonist for the same receptor and thereby reducing the ability of the full agonist to produce its maximum effect. The balance of activity between agonist and antagonist effects varies from one substance to another, according to their intrinsic activities, and is also influenced by the test system used to measure their effects.
okay so abilify is a partial agonist. full agonists are used for parkinsonss . Im sure abilify alone can produce an anti depressant effect if ur dopamine is low.I dont think I need a full dopamine agonist I think a partial agonist will do for me besides you dont want too much dopamine either that can lead to side effects. so abilify would be a good fit as it blocks some dopamine receptors too .
Posted by SLS on October 8, 2017, at 19:49:54
In reply to Re: Zyprexa + abilify + wellbutrin combo?, posted by farshad on October 8, 2017, at 14:24:18
> okay so abilify is a partial agonist. full agonists are used for parkinsonss . Im sure abilify alone can produce an anti depressant effect if ur dopamine is low.I dont think I need a full dopamine agonist I think a partial agonist will do for me besides you dont want too much dopamine either that can lead to side effects. so abilify would be a good fit as it blocks some dopamine receptors too .
I have not seen Abilify by itself produce a lasting antidepressant effect.
For you, given your current medications, I would suggest that you consider adding Lamictal to Wellbutrin and Abilify. Lamictal seems to be pro-dopaminergic, and possesses unequivocal antidepressant properties. I have seen these three drugs work extremely well for a friend of mine.
At this point, I think we must admit our impotence when trying to predict drug effects with certainty based upon what little we understand. Scientists just don't know enough yet. Sometimes, empirical evidence trumps theory. We can know what works without knowing why. For now, I think it is folly to allow personal theories regarding neurobiology dictate which drugs to try and which drugs not to try. It is perhaps more dangerous to eliminate drugs from consideration than to choose which to include. It would be a tragedy to deny a treatment that would work just because your theories don't predict it.
- Scott
This is the end of the thread.
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