Psycho-Babble Medication Thread 1094477

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Aug 2017 study: Vitamin D helps lamictal

Posted by PeterMartin on August 18, 2017, at 1:21:07

Just passing on a new study I came across today that found Vitamin D improved the effectiveness of Lamictal (at least in rats).

I do take Lamictal but vitamin D supplements always seem to make me depressed. Maybe I'll aim for more sunshine.

Study: http://www.sciencedirect.com/science/article/pii/S0006899317303475

Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats

Highlights

Vitamin D3 has significant anticonvulsant and cognitive improving effects in the PTZ-kindled rat model.

Vitamin D enhance the antiepileptic and cognitive effects of lamotrigine.

Anti-oxidative activity may contribute, at least partly, to neuroprotective effect of vitamin D.

Vitamin D supplementation may be a useful addition to antiepileptic drugs improving seizure control and cognitive function in patients with epilepsy.
Abstract
Despite long use of antiepileptic drugs, it remains a challenge to achieve seizure control while reducing adverse effects and preventing cognitive impairment. Several lines of evidence suggest a role of vitamin D in epilepsy. So this study aimed to investigate the effect of vitamin D on epileptogenesis, cognitive dysfunction and antiepileptic activity of lamotrigine, in a rat model of chemical kindling. Rats were kindled by pentylenetetrazole injections every other day over four weeks, together with daily oral treatment by either vehicle, vitamin D, lamotrigine or combination of vitamin D and lamotrigine. The non-treated kindled rats developed generalized seizures and had poor cognitive performance in water maze, associated with prooxidative status; elevated malondialdehyde and nitric oxide with lowered glutathione levels; in brain tissues. Treatment with either vitamin D, lamotrigine or both leads to significant reduction of seizure activity score, improvement of cognitive performance, and amelioration of the disturbed oxidative stress biomarkers. These findings indicate that, vitamin D has anti-epileptic, cognitive improving and antioxidant effects, on its own and enhance the effects of lamotrigine, in a chronic model of epileptic seizures. Thus, vitamin D supplementation may be a useful addition to antiepileptic drugs improving seizure control and cognitive function in patients with epilepsy

 

Re: Aug 2017 study: Vitamin D helps lamictal

Posted by linkadge on August 18, 2017, at 13:24:52

In reply to Aug 2017 study: Vitamin D helps lamictal, posted by PeterMartin on August 18, 2017, at 1:21:07

I have a love hate relationship with vitamin D supplementation.

For me, I've learned to keep the dose low (under 400 IU) and to only supplement a few times a week.

Like you, I have some negative mood reactions to it. It seems to increase headaches and general mood reactivity, but (for me) it can reduce some symptoms of depression, such as fatigue and apathy.

Linkadge

 

Re: Aug 2017 study: Vitamin D helps lamictal

Posted by baseball55 on August 18, 2017, at 19:05:36

In reply to Aug 2017 study: Vitamin D helps lamictal, posted by PeterMartin on August 18, 2017, at 1:21:07

. Maybe I'll aim for more sunshine.
>
Sunshine is always good and is the best source of Vitamin D.

 

Re: Aug 2017 study: Vitamin D helps lamictal PeterMartin

Posted by beckett2 on August 19, 2017, at 2:21:40

In reply to Aug 2017 study: Vitamin D helps lamictal, posted by PeterMartin on August 18, 2017, at 1:21:07

I take this as a reminder to keep my vit d levels up. Thank you.

 

Re: Aug 2017 study: Vitamin D helps lamictal

Posted by Ruuudy on August 24, 2017, at 17:22:39

In reply to Re: Aug 2017 study: Vitamin D helps lamictal PeterMartin, posted by beckett2 on August 19, 2017, at 2:21:40

I just read the study and was hoping to be able to see what dosage of vitamin D was used in the study.

I was showing a really low level of Vit D a few months ago - don't ever recall being tested for the "D"; I was instructed to add a vitamin D supplement @ 2,000iu daily.

I've read that people can be all over the map with the amount they take.
The past two days, I've bumped it up to 4,000 daily.

 

Re: Aug 2017 study: Vitamin D helps lamictal

Posted by Lamdage22 on November 22, 2017, at 11:51:07

In reply to Re: Aug 2017 study: Vitamin D helps lamictal, posted by Ruuudy on August 24, 2017, at 17:22:39

I take 7500 IU and it keeps the winter blues at bay.


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