Psycho-Babble Medication Thread 1094444

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Amitriptyline rechallenge

Posted by linkadge on August 15, 2017, at 22:06:29

So, after a few nights of good sleep, I tried amitriptyline again to see if it was the offending agent (causing insomnia vs. helping it).

I took 2.5mg

Within 30 min of taking it, I am much wider awake. I feel like I just drank an espresso. My heart is beating faster. I almost feel like I am going to have a seizure.

This is very strange, since in the past it had the exact opposite effect.

I literally have to take extra lorazepam to fight off the effect.

It's funny, I was taking nortriptyline just before the amitriptyline. Nortriptyline was causing less activation than amitriptyline!

Anyone who thinks these sedating drugs (i.e. amitriptyline, Seroquel, mirtazapine, trazodone) are more or less equivalent antihistamines in low doses is wrong.



Re: Amitriptyline rechallenge linkadge

Posted by SLS on August 16, 2017, at 6:01:05

In reply to Amitriptyline rechallenge, posted by linkadge on August 15, 2017, at 22:06:29

I don't know. Amitriptyline is much more anticholinergic than nortriptyline. That would help account for the increased heart rate and insomnia. Perhaps cyproheptadine would be better for insomnia with its 5-HT2a antagonism and antihistaminergic properties.

- Scott


Re: Amitriptyline rechallenge SLS

Posted by linkadge on August 16, 2017, at 11:37:28

In reply to Re: Amitriptyline rechallenge linkadge, posted by SLS on August 16, 2017, at 6:01:05

I'm going to see if I can go back to either mirtazapine (ideally) or nortriptyline.

Strange that nortriptyline is less activating than amitriptyline (for me)


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