Psycho-Babble Medication Thread 1089716

Shown: posts 1 to 12 of 12. This is the beginning of the thread.

 

Idiopathic hypersomnia

Posted by addinbc on June 19, 2016, at 17:10:33

Hi all,

I am in the process of being diagnosed with idiopathic hypersomnia. It finally fits my symptom profile so much better than any treatment resistant depression.

It comes complete with cognitive difficulties, worsens over time, and becomes very, very debilitating.

It is my firm belief that psychiatry neeeeeeeds to know more about this disorder because it is so often misdiagnosed and trying to medicate it incorrectly and worse, "talk therapy" out of it are exercises in futility and leaves one intensely frustrated and hopeless!

I frequently wonder how many people out there wwith"depression" are actually suffering from this.....

There are no official treatments for it, but stimulants often work.....bbut frequently poop out. Now clarithromycin - the antibiotic- has proven helpful for some.....like me! Check out Emory university sleep program for more info.

 

Re: Idiopathic hypersomnia

Posted by rjlockhart37 on June 19, 2016, at 19:57:43

In reply to Idiopathic hypersomnia, posted by addinbc on June 19, 2016, at 17:10:33


i would add wellbutrin, and a stimulant, mainly the amphetamines are the treatment, methyphediate is more just blockade of dopamine reptake......it doenst really wake you up like amphetamines do....amphetamine would be a good choice because dextroamphetamine doesnt produce the NE release like levoamphetamine. Having both of the isomers could help, adderall or eeveko

 

Re: Idiopathic hypersomnia

Posted by jonhed on June 21, 2016, at 13:25:49

In reply to Idiopathic hypersomnia, posted by addinbc on June 19, 2016, at 17:10:33

We had something called "amfetamin recip" in sweden that was 50/50 dex/levo.
It was gold standard in my opinion and i don't have a clue why it was so very very very different from just dexamphetamine.

I know the pharmakinetics but anyway, it was like the ratio did something amazing to it.

It came in 10mg pills and there was an experiment 7 years ago when people got 200-250mg of it per day. It was mental, and the experiment did not continue for long but the argument was to treat amphetamine abusers the same way as methadone and diacetylmorphine treated heroin addicts.

I'm rambling, sorry. But maybe some good information is coming from me sometimes.

 

Re: Idiopathic hypersomnia

Posted by Horse on June 21, 2016, at 15:53:45

In reply to Idiopathic hypersomnia, posted by addinbc on June 19, 2016, at 17:10:33

Interesting. Is that an experimental treatment? Does it have anti inflammatory properties?

 

Re: Idiopathic hypersomnia

Posted by addinbc on June 22, 2016, at 22:14:55

In reply to Re: Idiopathic hypersomnia, posted by Horse on June 21, 2016, at 15:53:45

Yes, so interesting! The neurology team down at Emory in Atlanta have found that many with central hypersomnia have something in their cerebral spinal fluid that causes hyperactivity at the GABA-A receptor which causes one to be as though perpetually drugged up on benzos.

Thanks discovered in their research that clarithromycin has GGABA-A receptor antagonism properties....it's not the antibiotic effect that is helpful, but rather this 'side effect' of it. It works wonders for me!

 

Re: Idiopathic hypersomnia

Posted by jonhed on June 24, 2016, at 4:23:15

In reply to Re: Idiopathic hypersomnia, posted by addinbc on June 22, 2016, at 22:14:55

That is awsome!
To that i can give you some more reading about tomorrows GABA-medications.
Some doctors in my hometown actually discovered this for many years ago and now it has become the next great hope for the medicine world.

I can't wait to try them.

Allopregnanolone
Tetrahydrodeoxycorticosterone, is some of them.

It's called Neurosteroids and are "ligands", or what it is called, of some anabolic steroids, but does not have their toxic and muscle building properties. Instead they have amazing properties.

One can think that i just looked it up on wikipedia but i've heard about this long before it was written there, but wiki is a good tool anyway so i will link to the wiki-pages for those who are interested.

There are trails going on here for difficult cases of pmds. Premenstrual dysphoric syndrome.
But are also undergoing "license" to try it for anxiety, schizofrenia and so on.

I think it sounds awsome.

https://en.wikipedia.org/wiki/Allopregnanolone
https://en.wikipedia.org/wiki/Tetrahydrodeoxycorticosterone

 

Re: Idiopathic hypersomnia

Posted by addinbc on June 24, 2016, at 22:28:59

In reply to Re: Idiopathic hypersomnia, posted by jonhed on June 24, 2016, at 4:23:15

Thank you jonhed. Very interesting!

Unfortunately though, IH requires the opposite to these medications. It needs meds that antagonize the GABAA receptor, blocking the hyperactivity causing the sleepiness. Drugs such as flumazenil, pitolisant, and clarithromycin are all GABAA
Receptor antagonists.

I hope the drugs you mentioned are found to be helpful for people who could benefit from them.

 

Re: Idiopathic hypersomnia

Posted by addinbc on June 25, 2016, at 10:26:05

In reply to Re: Idiopathic hypersomnia, posted by jonhed on June 24, 2016, at 4:23:15

Thank you jonhed. Very interesting!

Unfortunately though, IH requires the opposite to these medications. It needs meds that antagonize the GABAA receptor, blocking the hyperactivity causing the sleepiness. Drugs such as flumazenil, pitolisant, and clarithromycin are all GABAA
Receptor antagonists.

I hope the drugs you mentioned are found to be helpful for people who could benefit from them.

 

Re: Idiopathic hypersomnia

Posted by linkadge on June 25, 2016, at 11:40:53

In reply to Idiopathic hypersomnia, posted by addinbc on June 19, 2016, at 17:10:33

Do you have any other symptoms that resemble CFS?

You might try some ginger root (no really). I was recently suffering from extreme daily fatigue that resolved fairly quickly with ginger root.

Turmeric and ginger root have some efficacy in animal models of chronic fatigue, which may have roots in overactive inflammatory responses.

Linkadge

 

Re: Idiopathic hypersomnia » addinbc

Posted by linkadge on June 25, 2016, at 11:42:57

In reply to Re: Idiopathic hypersomnia, posted by addinbc on June 22, 2016, at 22:14:55

If GABA antagonists are helping you might consider adding cocoa powder.

The polyphenols in cocoa have endurance enhancing effects. Also, the beta carbolines are gaba-a antagonists.

Linkadge

 

Re: Idiopathic hypersomnia

Posted by linkadge on June 25, 2016, at 11:45:51

In reply to Re: Idiopathic hypersomnia, posted by jonhed on June 24, 2016, at 4:23:15

Allopregnanolone is a positive allosteric modulator of gaba-a responses. I.e. it enhances the effects of gaba on gaba-a receptors. If you believe that the gaba system is overactive you may which to try DHEA, which does the opposite ( negative allosteric modulator) of the gaba-a response.

I'm not sure if you can get DHEA as a supplement in the US? It used to be available in Canada, but not anymore.

Linkadge

 

Re: Idiopathic hypersomnia

Posted by linkadge on June 25, 2016, at 11:50:26

In reply to Re: Idiopathic hypersomnia, posted by addinbc on June 25, 2016, at 10:26:05

To add,

If you're not a coffee drinker, both caffeine and the beta carbolines in coffee functionally antagonize gaba responses.

Also the supplement PEA (trace amine) found in chocolate is a very powerful CNS stimulant. It antagonizes gaba responses. Do not combine this with MAO inhibiting drugs or supplements (at least not without extreme caution).

SSRIs are very poor treatments for fatigue. They tend to be better at treating anxiety (and possibly depression) than fatigue. Exceptions include Wellbutrin and NRI drugs like desipramine (if you have not tried these already).

Linkadge


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