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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by porkpiehat on April 5, 2014, at 13:57:34
I loved buspar for the first week (low dose plus SSRI). I could read, concentrate, make jokes, didn't feel social subordinated. Then insane anger kicked in.
I'm reading that it's likely pp-1 metabolite stimulating alpha2 adrenoreceptors (antagonizing I think)
http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20030604/msgs/232446.html
I'd love to start buspar again...it even helped sexually if I can recall. Would there be a way to block this action?
Please and thank you!
Posted by SLS on April 5, 2014, at 14:35:25
In reply to is there a drug that offsets buspar anger??, posted by porkpiehat on April 5, 2014, at 13:57:34
> I loved buspar for the first week (low dose plus SSRI). I could read, concentrate, make jokes, didn't feel social subordinated. Then insane anger kicked in.
>
> I'm reading that it's likely pp-1 metabolite stimulating alpha2 adrenoreceptors (antagonizing I think)
>
> http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20030604/msgs/232446.html
>
> I'd love to start buspar again...it even helped sexually if I can recall. Would there be a way to block this action?
>
> Please and thank you!
You could try Brintellix (vortioxetine) instead. It is not a DA receptor antagonist. It does not produce 1-PP. It has SERT inhibition, 5-HT1a partial agonism, and 5-HT7 antagonism. It should have little, if any, sexual side effects. It is new.
- Scott
Posted by porkpiehat on April 5, 2014, at 15:21:02
In reply to Re: is there a drug that offsets buspar anger?? » porkpiehat, posted by SLS on April 5, 2014, at 14:35:25
> > I loved buspar for the first week (low dose plus SSRI). I could read, concentrate, make jokes, didn't feel social subordinated. Then insane anger kicked in.
> >
> > I'm reading that it's likely pp-1 metabolite stimulating alpha2 adrenoreceptors (antagonizing I think)
> >
> > http://www.dr-bob.org/cgi-bin/pb/mget.pl?post=/babble/20030604/msgs/232446.html
> >
> > I'd love to start buspar again...it even helped sexually if I can recall. Would there be a way to block this action?
> >
> > Please and thank you!
>
>
> You could try Brintellix (vortioxetine) instead. It is not a DA receptor antagonist. It does not produce 1-PP. It has SERT inhibition, 5-HT1a partial agonism, and 5-HT7 antagonism. It should have little, if any, sexual side effects. It is new.
>
>
> - ScottThat sounds exciting! My pdoc had mentioned it but was unsure of its efficacy this early on She did describe it as SSRI+buspar, however.
I notice that it is also a NE transporter blocker. Would that cause similar agitation? Wellbutrin, Zoloft, and serzone all incited anger in me also, if that's any indication
Posted by LouisianaSportsman on April 5, 2014, at 22:05:08
In reply to Re: is there a drug that offsets buspar anger?? » SLS, posted by porkpiehat on April 5, 2014, at 15:21:02
>
> That sounds exciting! My pdoc had mentioned it but was unsure of its efficacy this early on She did describe it as SSRI+buspar, however.
>
> I notice that it is also a NE transporter blocker. Would that cause similar agitation? Wellbutrin, Zoloft, and serzone all incited anger in me also, if that's any indication
>
>Vortioxetine(Brintellix) Ki at NET is 113 nM which means it is very weak.
For reference, Ki value for bupropion (Wellbutrin) is 1.4.
I don't see it causing any agitation due to this property. It doesn't cause any agitation for me, and I take 20mg. a day.
You could also try Viibyrd (vilazodone). It also has 5-HT1a partial agonism.
This is the end of the thread.
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