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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by BrainDamage on March 28, 2014, at 14:28:38
Brexpiprazole
It should be approved in the next few years-hopefully
Looks a bit more promising than some of the more recent drugs, to my tired eyes at least
Posted by SLS on March 28, 2014, at 17:20:03
In reply to Brexpiprazole-Here it comes, posted by BrainDamage on March 28, 2014, at 14:28:38
> Brexpiprazole
>
> It should be approved in the next few years-hopefully
> Looks a bit more promising than some of the more recent drugs, to my tired eyes at least
>
> http://en.wikipedia.org/wiki/BrexpiprazoleWhat do you find appealing about this drug? What conditions are you treating?
Is there any advantage to brexpiprazole over aripiprazole (Abilify) with regard to side effects? Weight gain?
Cariprazine is a similar drug that I believe might be better for depression. It is like adding 5-HT7 antagonism to Abilify with emphasis on the D3 reward system.
http://en.wikipedia.org/wiki/Cariprazine
- Scott
Posted by BrainDamage on March 29, 2014, at 5:09:49
In reply to Re: Brexpiprazole-Here it comes » BrainDamage, posted by SLS on March 28, 2014, at 17:20:03
> Is there any advantage to brexpiprazole over aripiprazole (Abilify) with regard to side effects? Weight gain?
>
> Cariprazine is a similar drug that I believe might be better for depression. It is like adding 5-HT7 antagonism to Abilify with emphasis on the D3 reward system.
> - Scott
Don't Overestimate me Scott! ;)If there were Pharmacologist grades on this Sight I would be "Dabbler" & You & Ed among Others would be "Professional-Amateur"
To be honest its probably another useless "Me-Too" drug
I did noticed that the Patent on Abilify was about to run out......I also noticed that they were trying to get it approved for ADHD, which made me hopeful
This is probably more to do with Money than with Brexpiprazole being any better for ADHD than Cariprazine
Posted by SLS on March 29, 2014, at 6:58:04
In reply to Re: Brexpiprazole-Here it comes, posted by BrainDamage on March 29, 2014, at 5:09:49
> > Cariprazine is a similar drug that I believe might be better for depression. It is like adding 5-HT7 antagonism to Abilify with emphasis on the D3 reward system.
> Don't Overestimate me Scott! ;)
>
> If there were Pharmacologist grades on this Sight I would be "Dabbler" & You & Ed among Others would be "Professional-Amateur"I know less about psychiatry than what people assume I do. I just use big words. Fortunately, there are people with true knowledge and expertise posting on Psycho-Babble. I try to learn from everyone.
> To be honest its probably another useless "Me-Too" drug
I don't mind taking a "me too" drug if it were to mean that I could then be included in the "me too" club of treatment responders. It might be that a subtle difference in drugs will convert a TRD into a treatment success. For every new drug that becomes available, a certain percentage of previously treatment-resistant individuals will respond to it.
I wish us both luck!
- Scott
Posted by jrbecker76 on April 2, 2014, at 12:56:21
In reply to Re: Brexpiprazole-Here it comes » BrainDamage, posted by SLS on March 29, 2014, at 6:58:04
> > > Cariprazine is a similar drug that I believe might be better for depression. It is like adding 5-HT7 antagonism to Abilify with emphasis on the D3 reward system.
>
> > Don't Overestimate me Scott! ;)
> >
> > If there were Pharmacologist grades on this Sight I would be "Dabbler" & You & Ed among Others would be "Professional-Amateur"
>
> I know less about psychiatry than what people assume I do. I just use big words. Fortunately, there are people with true knowledge and expertise posting on Psycho-Babble. I try to learn from everyone.
>
> > To be honest its probably another useless "Me-Too" drug
>
> I don't mind taking a "me too" drug if it were to mean that I could then be included in the "me too" club of treatment responders. It might be that a subtle difference in drugs will convert a TRD into a treatment success. For every new drug that becomes available, a certain percentage of previously treatment-resistant individuals will respond to it.
>
> I wish us both luck!
>
>
> - ScottFrom a receptor affinity standpoint, Brex as the metabolite of Abilify is in itself less of a D2 partial agonist and more of a direct antagonist. From this logic, I would suspect that it's not necessarily an improvement in terms of providing a better antidepressant effect over Abilify itself.
Posted by SLS on April 2, 2014, at 19:47:41
In reply to Re: Brexpiprazole-Here it comes, posted by jrbecker76 on April 2, 2014, at 12:56:21
Hi JRB.
How have you been?
I've been stuck as a partial responder. I can survive this way, but I don't want to live this way.
- Scott
This is the end of the thread.
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