Psycho-Babble Medication Thread 1043087

Shown: posts 1 to 13 of 13. This is the beginning of the thread.

 

A Cry for Help!

Posted by lillabella on May 2, 2013, at 14:27:21

Has anyone really figured out why some of us have seemingly 'opposite reactions' to psychotrophic meds?? Is it something to do with our synapses firing or not firing? A depletion of neurotransmittors? Is there any help? I ask because I have these opposite reactions to 99% of all meds and am therefore treatment resistant. I will mention a few:

Prozac---major anxiety/wanted to jump out of my
skin--and it lasted for 3 days after one
dose!

Wellbutrin---only med that made me ++suicidal---+
hostile and agigtated in a manic,dark
way...

Lithium--- super manic in a black way--aggressive,
angry and hostile. Had amazing energy
could not even pretend to sleep but
hated everything and everybody!!!

Seroquel----see lithium

Effexor--- major insomnia and anxiety

Topamax-- hostile and angry and *STUPID* could not
function at my job and again manic!

Nardil--- Manic in what I thought was a good way
but really off the wall in highsight
+ huge weight-gain/water retention---
looked like I was 9 months pregant!

Parnate-- somewhat manic but felt good inspite of
nodding off when sitting still but hey
it stopped working! or I would still be
on it!!!! I miss the parnate a lot!!

Amitripyline-- major shakes and tremor

Paxil---------felt drugged and dazed

ALL of the Stims---feel like a zombie/zero
motivation or drive/want to lie
in bed all day and sleep

My diagnoses is Bipolar Disorder with Attention Defecit Disorder.

I have been at this game for a long time and following this board since the early ninities. Right now I am deeply depressed and not sure what to ask my doctor for next week. I currently take a small amount of vyvanse because in spite of everything I can focus somewhat better with it even if it saps me of any drive I might have except to lie in bed and read. I also take zoloft to help with depression but I still cry everyday and rarely get out of bed.
I take some clonazapam which helps with my anxiety and insomnia.

Does anyone have any suggestions as to what I might augment the above meds with to lift the depression and give me some energy? Yes I have tried all the anti-convulsants plus lamictal plus gabapentin etc. etc. None of them did a thing.

Please help as I feel so low right now and don't know what to do. Why is it that meds stop working?? I would love to try nardil with a small amount of vyvanse as strangely vyvance acts as an anti-manic for me. But I know my p-doc won't go for it. A cry for help...thank-you

 

Re: A Cry for Help! » lillabella

Posted by Phillipa on May 2, 2013, at 15:31:00

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

May I say please do not give up hope. I also relate to my first attempts with SSRI's. No anxiety relief. I do hope someone on here will be able to help. Please hang in there. Phillipa

 

Re: A Cry for Help!

Posted by polarbear206 on May 2, 2013, at 17:06:47

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

Have you tried lamictal???

 

Re: A Cry for Help!

Posted by gpznos on May 2, 2013, at 17:09:26

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

Hi, Have you considered Marplan? It is a MAOi but lying in between Parnate and Nardil as I understand it from various posts here (I have NOT tried Parnate or Nardil, not available where I live).
I am on Marplan and getting a lot of relief compared to other med-combos I have been on. I also take Nortriptyline and Lithium (small dose 600 mg to prevent relapse). I have uni-polar depression.

 

Lou's response- » lillabella

Posted by Lou PIlder on May 2, 2013, at 22:06:19

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

> Has anyone really figured out why some of us have seemingly 'opposite reactions' to psychotrophic meds?? Is it something to do with our synapses firing or not firing? A depletion of neurotransmittors? Is there any help? I ask because I have these opposite reactions to 99% of all meds and am therefore treatment resistant. I will mention a few:
>
> Prozac---major anxiety/wanted to jump out of my
> skin--and it lasted for 3 days after one
> dose!
>
> Wellbutrin---only med that made me ++suicidal---+
> hostile and agigtated in a manic,dark
> way...
>
> Lithium--- super manic in a black way--aggressive,
> angry and hostile. Had amazing energy
> could not even pretend to sleep but
> hated everything and everybody!!!
>
> Seroquel----see lithium
>
> Effexor--- major insomnia and anxiety
>
> Topamax-- hostile and angry and *STUPID* could not
> function at my job and again manic!
>
> Nardil--- Manic in what I thought was a good way
> but really off the wall in highsight
> + huge weight-gain/water retention---
> looked like I was 9 months pregant!
>
> Parnate-- somewhat manic but felt good inspite of
> nodding off when sitting still but hey
> it stopped working! or I would still be
> on it!!!! I miss the parnate a lot!!
>
> Amitripyline-- major shakes and tremor
>
> Paxil---------felt drugged and dazed
>
> ALL of the Stims---feel like a zombie/zero
> motivation or drive/want to lie
> in bed all day and sleep
>
> My diagnoses is Bipolar Disorder with Attention Defecit Disorder.
>
> I have been at this game for a long time and following this board since the early ninities. Right now I am deeply depressed and not sure what to ask my doctor for next week. I currently take a small amount of vyvanse because in spite of everything I can focus somewhat better with it even if it saps me of any drive I might have except to lie in bed and read. I also take zoloft to help with depression but I still cry everyday and rarely get out of bed.
> I take some clonazapam which helps with my anxiety and insomnia.
>
> Does anyone have any suggestions as to what I might augment the above meds with to lift the depression and give me some energy? Yes I have tried all the anti-convulsants plus lamictal plus gabapentin etc. etc. None of them did a thing.
>
> Please help as I feel so low right now and don't know what to do. Why is it that meds stop working?? I would love to try nardil with a small amount of vyvanse as strangely vyvance acts as an anti-manic for me. But I know my p-doc won't go for it. A cry for help...thank-you

lillabella,
You wrote,[...has anyone really figured out...Is there any help?...right now I am deeply depressed...please help..A cry for help...].

 

Re: A Cry for Help! » lillabella

Posted by SLS on May 3, 2013, at 0:04:19

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

You are amazingly resolved and resilient after all of these years.

You certainly are a challenge, but I get the feeling that you are treatable based upon the fact that you have responded favorably in one way or another to some of your previous treatments. Your brain is still responsive. For quite awhile, mine wasn't. I have been a total flat-liner for most of the last 30 years. I was lucky if a treatment could budge me for more than 3 days.

Have you thought about having rTMS?

Have you tried ECT?

What other antipsychotics have you tried.

Remeron?

I would have thought that Trileptal would be helpful.

You might be headed in the direction of using an antidepressant, antipsychotic, and mood stabilizer.
Don't be discouraged if no one has a miracle answer for you by tomorrow. It will take people some time to digest the information you have provided.

I am one of those bipolar cases for which mania presents itself only as a reaction to antidepressants. Otherwise, I am chronically depressed. However, I have been feeling substantially better taking:

Parnate 80 mg/day
nortriptyline 150 mg/day
Lamictal 300 mg/day
lithium 450 mg/day
Abilify 10 mg/day
prazosin 6 mg/day
minocycline 200 mg/day

If there is a history of childhood trauma, neglect, or PTSD, you might want to take a look at prazosin. To me, it feels like a very clean antidepressant without a tendency to feel overmedicated or uncomfortably activated.

I am beginning to think of minocycline as being "aspirin for the brain". It reduced inflammation and helps to squelch overactive glutamate circuits. Some people experience an improvement in depression during the first week. Minocycline also acts as a neuroprotective and promotes neurogenesis. So far, it has not been observed to increase serotonergic tone like lithium does. Minocycline might thus reduce depression without triggering mania, mixed-states, or activation/agitation.

Lou Pilder makes it a habit of changing subject lines so that his name appears prominently and repeatedly. The theme of the thread is lost unless someone makes it a point to reset the subject line to its original verbiage.

Good luck.


- Scott

 

Re: A Cry for Help! » lillabella

Posted by SLS on May 4, 2013, at 11:12:17

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

How are you?


- Scott

 

Lou's response-mhordhfm

Posted by Lou Pilder on May 5, 2013, at 10:02:32

In reply to Lou's response- » lillabella, posted by Lou PIlder on May 2, 2013, at 22:06:19

> > Has anyone really figured out why some of us have seemingly 'opposite reactions' to psychotrophic meds?? Is it something to do with our synapses firing or not firing? A depletion of neurotransmittors? Is there any help? I ask because I have these opposite reactions to 99% of all meds and am therefore treatment resistant. I will mention a few:
> >
> > Prozac---major anxiety/wanted to jump out of my
> > skin--and it lasted for 3 days after one
> > dose!
> >
> > Wellbutrin---only med that made me ++suicidal---+
> > hostile and agigtated in a manic,dark
> > way...
> >
> > Lithium--- super manic in a black way--aggressive,
> > angry and hostile. Had amazing energy
> > could not even pretend to sleep but
> > hated everything and everybody!!!
> >
> > Seroquel----see lithium
> >
> > Effexor--- major insomnia and anxiety
> >
> > Topamax-- hostile and angry and *STUPID* could not
> > function at my job and again manic!
> >
> > Nardil--- Manic in what I thought was a good way
> > but really off the wall in highsight
> > + huge weight-gain/water retention---
> > looked like I was 9 months pregant!
> >
> > Parnate-- somewhat manic but felt good inspite of
> > nodding off when sitting still but hey
> > it stopped working! or I would still be
> > on it!!!! I miss the parnate a lot!!
> >
> > Amitripyline-- major shakes and tremor
> >
> > Paxil---------felt drugged and dazed
> >
> > ALL of the Stims---feel like a zombie/zero
> > motivation or drive/want to lie
> > in bed all day and sleep
> >
> > My diagnoses is Bipolar Disorder with Attention Defecit Disorder.
> >
> > I have been at this game for a long time and following this board since the early ninities. Right now I am deeply depressed and not sure what to ask my doctor for next week. I currently take a small amount of vyvanse because in spite of everything I can focus somewhat better with it even if it saps me of any drive I might have except to lie in bed and read. I also take zoloft to help with depression but I still cry everyday and rarely get out of bed.
> > I take some clonazapam which helps with my anxiety and insomnia.
> >
> > Does anyone have any suggestions as to what I might augment the above meds with to lift the depression and give me some energy? Yes I have tried all the anti-convulsants plus lamictal plus gabapentin etc. etc. None of them did a thing.
> >
> > Please help as I feel so low right now and don't know what to do. Why is it that meds stop working?? I would love to try nardil with a small amount of vyvanse as strangely vyvance acts as an anti-manic for me. But I know my p-doc won't go for it. A cry for help...thank-you
>
> lillabella,
> You wrote,[...has anyone really figured out...Is there any help?...right now I am deeply depressed...please help..A cry for help...].
> I could have you delivered out of your depression, unshackled from addiction, and into a new life where you could sing a new song. But there are members here slandering me and defaming me and posting false accusations toward me, all allowed by Mr Hsiung and his deputy. This could sway you to discount what I could say to you. But to make it worse for me to help you, Mr Hsiung has posted many prohibitions to me here that prevent me from posting what I need in order for you to be free. It would come from a Jewish perspective which is prohibited for me to post as revealed to me. And even worse, the poster under me here has falsely accused me of posting so that my name appears frequently. That is allowed by Mr Hsiung, which could keep you from getting the help that you want, from me at least. If you want to see more of the hate that is allowed to stand here toward me, go to the admin board and see how Mr Hsiung is in concert with the members that are using this forum to post hatred toward the Jews and myself, even Mr Hsiung using the epithet against me as The Prince of Death.
Did Scott's post here make you think twice about responding to me? If so, I pity all the readers here that are allowed to be swayed to discount what I post, for I have come here to save lives, prevent life-ruining conditions and addictions, and show how one could have a new life, free from being scared about that the drugs could kill them, or to induce a mind-altered state to compel them to commit murder, even mass-murder or kill their own mother.
Lou

 

Re: A Cry for Help! » lillabella

Posted by SLS on May 5, 2013, at 12:17:32

In reply to A Cry for Help!, posted by lillabella on May 2, 2013, at 14:27:21

Hi Lillabella.

What's happening?


- Scott

 

Re: please be civil » Lou Pilder

Posted by Dr. Bob on May 6, 2013, at 23:38:09

In reply to Lou's response-mhordhfm, posted by Lou Pilder on May 5, 2013, at 10:02:32

> there are members here slandering me and defaming me and posting false accusations toward me

Please don't post anything that could lead others to feel accused or put down.

More information about posting policies and tips on alternative ways to express yourself, including a link to a nice post by Dinah on I-statements, are in the FAQ:

http://www.dr-bob.org/babble/faq.html#civil
http://www.dr-bob.org/babble/faq.html#enforce

Follow-ups regarding administrative issues should be redirected to Psycho-Babble Administration. They, as well as replies to the above post, should of course themselves be civil.

Thanks,

Bob

 

Re: A Cry for Help!

Posted by lillabella on May 8, 2013, at 10:16:58

In reply to Re: A Cry for Help! » lillabella, posted by SLS on May 5, 2013, at 12:17:32

Thank-you all for your kind and encouraging words of support. In particular thank you Scott for your heart-felt interest. I have followed your posts for so many years now and am amazed at your knowledge, empathy and strength.

I saw my doctor yesterday. He is rather cold and unwilling to try anything new. I begged him to put me on a small dose of Nardil with a small dose of Vyvanse but that was a no go for sure. I had to practically beg him to put me on Pristiq, as he wouldn't go for Moclobemide either, which is available here in Canada. Unfortunately Marplan is not available here or so I believe. He did however agree to Pristiq. I took Effexor many moons ago and it was energizing but had lots of side effects but I was desperate and went for it.

I have stopped the Vyvanse as all the stims gave me a 'zombie' like response. Amazingly the Pristiq has no side effects whatsoever! I feel somewhat better but it is too early to say. I've read you have to be on this med a while to get the full benefit but I usually know from the start if I will get a good response.

Feel a bit shakey as have been on stims for a year now and suddenly off but I do feel better overall and think I will not take them again.

I mentioned in my last post that lithium made me so energized (manic??) yet hostile and angry. Is this what is called a 'mixed state'? Is it possible to tease out the meaness with an antidepressant but hold on to the energy I experienced? I had the same reaction to Seroquel altho to a lesser degree.

It's so hard to find a p-doc here and even harder to find one that will prescribe a low dose stim with Nardil which could work for me. Parnate was my magic bullet but after having my brain messed around with a bunch of other heavy anti-psychotics it stopped working much to my never ending grief.

What is the'aspirn for the brain' drug that you mentioned Scott? Is it similiar to Aricept?? I know my doctor would never allow it but I could perhaps order it online atho in Canada it is so hard to order any meds online.

Also has anyone had a good experience with lithium? What about Prozac? I had a bad experience with it after one dose some 20 years ago so wondering if I might have a better reaction now since my reaction to Effexor has changed. I am willing to try anything at his point. Being so treatment resistant is not an easy ride as many of you out there must know.

My thanks to you all and much appreciation...lillabella

 

Re: A Cry for Help! » lillabella

Posted by SLS on May 8, 2013, at 12:05:11

In reply to Re: A Cry for Help!, posted by lillabella on May 8, 2013, at 10:16:58

> Amazingly the Pristiq has no side effects whatsoever!

Yes. Pristiq is earning a reputation for being more forgiving with respect to side effects than is Effexor. In addition, some people are responding better to Pristiq than they did to Effexor. However, I would not want to generalize. I doubt that this is true in all cases.

> I feel somewhat better

Great!

> but it is too early to say.

Yes, it is. However, it is a good sign that you experienced a "blip" improvement, even if it does not persist beyond the first few days. How long have you been taking Pristiq, and what is your dosage?

> What is the'aspirn for the brain' drug that you mentioned Scott?

The drug is called minocycline. It is currently used as an antibiotic, but it has many properties that influences brain biology.

http://www.dr-bob.org/babble/20120803/msgs/1023257.html

http://bmjopen.bmj.com/content/2/1/e000643.full

Minocycline is currently being studied in clinical trials for depression - mostly bipolar depression - which is what you probably have.

http://clinicaltrials.gov/show/NCT01403662

http://clinicaltrialsfeeds.org/clinical-trials/show/NCT01403662

http://clinicaltrials.gov/ct2/show/NCT01514422

Good luck with the Pristiq!


- Scott

 

How do I switch doctors?/Cry for help?

Posted by lillabella on May 9, 2013, at 11:49:48

In reply to Re: A Cry for Help! » lillabella, posted by SLS on May 8, 2013, at 12:05:11

Thanks Scott, your links were most insightful but I'm sure my p-doc will never prescribe minocycline. After one year on the same med proticol he finally let me change my antidepressant from Zoloft to Pristiq and that was only after I begged. I think I need a new doctor but how does one tell your doctor you want out?? My GP is much more open to prescribing meds and as my p-doc sees me for no more than 30 minutes and is usually in a bad mood I think I would do better to switch. Have to admit I am intimitated by him and don't know how to end our relationship. Any suggestions? Thanks again to all and especially to you Eric..........,lilla


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