Psycho-Babble Medication Thread 1023891

Shown: posts 1 to 12 of 12. This is the beginning of the thread.

 

help- trazodone stopped working

Posted by novelagent on August 22, 2012, at 2:11:31

I've never had a med stop working before, but Trazodone 100mg doesn't work anymore after starting it 3weeks ago. What else is there? I have sexual dysfunction from Effezor-- is Remeron going to let me heal from that, or is it enough like effexor to prolong the damage? I vaguely think i recall it's sometimes used for sex dysfunction-- isn't it a partial dopamine agonist?

I'd take seroquel, but I'm already on Invega Sustenna injections. I'm out of ideas. Unisom isn't doing anything, and melatonin doesn't work for me. Ambien is off the table, because I have a community clinic doc, and everyone knows they don't prescribe meds that work (klonopin also off table).

 

Re: help- trazodone stopped working » novelagent

Posted by SLS on August 22, 2012, at 6:30:18

In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31

> I've never had a med stop working before, but Trazodone 100mg doesn't work anymore after starting it 3weeks ago. What else is there? I have sexual dysfunction from Effezor-- is Remeron going to let me heal from that, or is it enough like effexor to prolong the damage? I vaguely think i recall it's sometimes used for sex dysfunction-- isn't it a partial dopamine agonist?
>
> I'd take seroquel, but I'm already on Invega Sustenna injections. I'm out of ideas. Unisom isn't doing anything, and melatonin doesn't work for me. Ambien is off the table, because I have a community clinic doc, and everyone knows they don't prescribe meds that work (klonopin also off table).

Why was trazodone prescribed? How did it affect you?

Have you thought to try nefazodone?

For how long did you take Effexor? You can try adding Wellbutrin to Effexor if anxiety isn't a problem. It would make Effexor work better for depression and help to remediate sexual dysfunction. The combination can be very effective to treat depression, especially atypical or anergic subtypes.

If Effexor works well, you can also try adding buspirone to help ameliorate sexual dysfunction. It might even help with depression.

Parnate?

Nortriptyline?

Viibryd?

Viibryd (vilazodone) would be an interesting choice for you. It is an SSRI / 5-HT1a partial agonist that does not tend to produce sexual side effects.

Using Remeron as an adjunct to Effexor might be exactly the right thing to do according to some people. The combination was once popular and known as "California Rocket Fuel". I am not sure about the capacity of Remeron to reduce sexual impairments. If arousal and anorgasmia are issues, cyproheptadine (Periactin) can be taken just before having sex. It can be sedating, though. Periactin and Remeron both antagonize 5-HT2a/c receptors. However, Periactin also antagonizes 5-HT2b receptors, which is an important property to improve sexual function.

Buspar (buspirone) is often chosen as a remedy for SRI-induced sexual impairments. It can also enhance the therapeutic response to antidepressants and reduce sexual impairments.


- Scott

 

Re: help- trazodone stopped working (for insomnia) » SLS

Posted by Novelagent on August 22, 2012, at 11:39:57

In reply to Re: help- trazodone stopped working » novelagent, posted by SLS on August 22, 2012, at 6:30:18

I'm only taking the trazodone for insomnia. I'm not depressed, and antidepressants don't work on social anxiety.

I ha a doc tell me wellbutrin wouldn't do anything for sexual dysfunction for me because it only works at that by increasing dopamine, and I'm already on Vyvanse. Is it possible this is an over-simplification, and Wellbutrin does more than this?

I've tried Claritin, and it didn't do anything, so I'm not sure cyproheptadine would work. I've taken Buspar years ago for anxiety and had to go off it-- it gave me akathisia.

I can't take Effexor anymore because I need my brain to heal.

I'm concerned Remeron might just take it that much longer to heal, because isn't it also just another SSRI, or is it a partial dopamine agonist?

Anyway, I need something sedating, but it seems like the only things that work are controlled meds that my doc won't prescribe, because my doc is the type who doesn't prescribe hypnotics or benzos.
> > I've never had a med stop working before, but Trazodone 100mg doesn't work anymore after starting it 3weeks ago. What else is there? I have sexual dysfunction from Effezor-- is Remeron going to let me heal from that, or is it enough like effexor to prolong the damage? I vaguely think i recall it's sometimes used for sex dysfunction-- isn't it a partial dopamine agonist?
> >
> > I'd take seroquel, but I'm already on Invega Sustenna injections. I'm out of ideas. Unisom isn't doing anything, and melatonin doesn't work for me. Ambien is off the table, because I have a community clinic doc, and everyone knows they don't prescribe meds that work (klonopin also off table).
>
> Why was trazodone prescribed? How did it affect you?
>
> Have you thought to try nefazodone?
>
> For how long did you take Effexor? You can try adding Wellbutrin to Effexor if anxiety isn't a problem. It would make Effexor work better for depression and help to remediate sexual dysfunction. The combination can be very effective to treat depression, especially atypical or anergic subtypes.
>
> If Effexor works well, you can also try adding buspirone to help ameliorate sexual dysfunction. It might even help with depression.
>
> Parnate?
>
> Nortriptyline?
>
> Viibryd?
>
> Viibryd (vilazodone) would be an interesting choice for you. It is an SSRI / 5-HT1a partial agonist that does not tend to produce sexual side effects.
>
> Using Remeron as an adjunct to Effexor might be exactly the right thing to do according to some people. The combination was once popular and known as "California Rocket Fuel". I am not sure about the capacity of Remeron to reduce sexual impairments. If arousal and anorgasmia are issues, cyproheptadine (Periactin) can be taken just before having sex. It can be sedating, though. Periactin and Remeron both antagonize 5-HT2a/c receptors. However, Periactin also antagonizes 5-HT2b receptors, which is an important property to improve sexual function.
>
> Buspar (buspirone) is often chosen as a remedy for SRI-induced sexual impairments. It can also enhance the therapeutic response to antidepressants and reduce sexual impairments.
>
>
> - Scott

 

Re: help- trazodone stopped working

Posted by rjlockhart37 on August 22, 2012, at 13:13:36

In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31

check out Rozerem....its wellknown with doctors who are picky with sleep meds....paticually benzos and ambien.

Doxepin is another option, great for sleep and similar to trazadone.

 

Re: help- trazodone stopped working » novelagent

Posted by Alexei on August 22, 2012, at 16:18:20

In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31

Seroquel has worked wonders for me for a lot of symptoms, especially sleep and anxiety. Would you consider switching from invega to seroquel?

 

Re: help- trazodone stopped working

Posted by jono_in_adelaide on August 22, 2012, at 18:26:09

In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31

Try Doxepin, between 10mg and 50mg at night

 

Re: help- trazodone stopped working

Posted by jono_in_adelaide on August 22, 2012, at 18:27:43

In reply to Re: help- trazodone stopped working, posted by jono_in_adelaide on August 22, 2012, at 18:26:09

Have a look on google, its an old tricyclic that has a strong evedence base for insomnia. It isnt habit forming, its dirt cheap, and it works.

 

Re: help- trazodone stopped working » novelagent

Posted by phidippus on August 28, 2012, at 20:03:21

In reply to help- trazodone stopped working, posted by novelagent on August 22, 2012, at 2:11:31

Mirtazapine is an antagonist/inverse agonist at the following receptors:[64][65]

5-HT1A receptor (Ki=18nM; IC50=1,000nM) [66]
5-HT2A receptor (Ki = 69 nM)
5-HT2B receptor (Ki = ? (~20-fold lower than for 5-HT2A/2C))[67]
5-HT2C receptor (Ki = 39 nM)
5-HT3 receptor (Ki = ? (similar to 5-HT2A/2C (mouse neuroblastoma cell)))[68]
5-HT7 receptor (Ki = 265 nM)
α1-adrenergic receptor (Ki = 608 nM (rat))
α2A-adrenergic receptor (Ki = 20 nM)
α2B-adrenergic receptor (Ki = ? nM (likely similar to α2A/α2B-adrenergic))[citation needed]
α2C-adrenergic receptor (Ki = 18 nM)
H1 receptor (Ki = 1.6 nM)
mACh receptors (Ki = 794 nM (rat))
Dopamine D1 receptor (Ki=4,167nM) [69]
Dopamine D2 receptor (Ki=1,460nM) [70]
Dopamine D3 receptor (Ki=5,723nM) [71]
Dopamine D4 receptor (Ki=25nM)

In contrast to mirtazapine, the SSRIs, SNRIs, MAOIs, and some TCAs increase the general activity of the 5-HT2A, 5-HT2C, and 5-HT3 receptors leading to a host of negative changes and side effects, the most prominent of which include anorexia, insomnia, sexual dysfunction (loss of libido and anorgasmia),

In addition, mirtazapine's antagonism of the 5-HT2A and 5-HT2C receptors has beneficial effects on anxiety, sleep and appetite, as well as sexual function regarding the latter receptor


Eric

 

Re: help- trazodone stopped working » phidippus

Posted by Novelagent on August 31, 2012, at 15:24:05

In reply to Re: help- trazodone stopped working » novelagent, posted by phidippus on August 28, 2012, at 20:03:21

Thanks. Does trazodone cause sexual dysfunction? It works now-- it turns out i was takibg vyvanse too late at 9:30AM; I take vyvanse no later than 9AM now.

> Mirtazapine is an antagonist/inverse agonist at the following receptors:[64][65]
>
> 5-HT1A receptor (Ki=18nM; IC50=1,000nM) [66]
> 5-HT2A receptor (Ki = 69 nM)
> 5-HT2B receptor (Ki = ? (~20-fold lower than for 5-HT2A/2C))[67]
> 5-HT2C receptor (Ki = 39 nM)
> 5-HT3 receptor (Ki = ? (similar to 5-HT2A/2C (mouse neuroblastoma cell)))[68]
> 5-HT7 receptor (Ki = 265 nM)
> α1-adrenergic receptor (Ki = 608 nM (rat))
> α2A-adrenergic receptor (Ki = 20 nM)
> α2B-adrenergic receptor (Ki = ? nM (likely similar to α2A/α2B-adrenergic))[citation needed]
> α2C-adrenergic receptor (Ki = 18 nM)
> H1 receptor (Ki = 1.6 nM)
> mACh receptors (Ki = 794 nM (rat))
> Dopamine D1 receptor (Ki=4,167nM) [69]
> Dopamine D2 receptor (Ki=1,460nM) [70]
> Dopamine D3 receptor (Ki=5,723nM) [71]
> Dopamine D4 receptor (Ki=25nM)
>
> In contrast to mirtazapine, the SSRIs, SNRIs, MAOIs, and some TCAs increase the general activity of the 5-HT2A, 5-HT2C, and 5-HT3 receptors leading to a host of negative changes and side effects, the most prominent of which include anorexia, insomnia, sexual dysfunction (loss of libido and anorgasmia),
>
> In addition, mirtazapine's antagonism of the 5-HT2A and 5-HT2C receptors has beneficial effects on anxiety, sleep and appetite, as well as sexual function regarding the latter receptor
>
>
> Eric

 

Re: help- trazodone stopped working » Novelagent

Posted by phidippus on August 31, 2012, at 15:39:08

In reply to Re: help- trazodone stopped working » phidippus, posted by Novelagent on August 31, 2012, at 15:24:05

Trazadone can cause sexual dysfunction. Are you suffering from sexual dysfunction? Are you looking for pharmacological intervention? If you are I have a few suggestions.

I take Vyvanse to.

Eric

 

Re: help- trazodone stopped working » phidippus

Posted by Novelagent on September 6, 2012, at 1:21:13

In reply to Re: help- trazodone stopped working » Novelagent, posted by phidippus on August 31, 2012, at 15:39:08

Yes, I have sexual dysfunction after taking 1000mg of Effexor. Please help.

> Trazadone can cause sexual dysfunction. Are you suffering from sexual dysfunction? Are you looking for pharmacological intervention? If you are I have a few suggestions.
>
> I take Vyvanse to.
>
> Eric

 

Re: help- trazodone stopped working » Novelagent

Posted by phidippus on September 6, 2012, at 15:07:31

In reply to Re: help- trazodone stopped working » phidippus, posted by Novelagent on September 6, 2012, at 1:21:13

Wellbutrin is often prescribed to reverse the sexual side effects of antidepressants. It increases dopamine and central dopamine is a key neurotransmitter in the control of sexual function.

Mirapex and Requip are dopamine agonists, which means they increase dopamine in the brain. one of the side effects of these drugs is hypersexuality.

Nuvigil acts on Orexin. Orexinergic neurons are found exclusively in the lateral hypothalamic area. Their activation is associated with enhanced pleasure-seeking and motivation as well as arousal.

Mirtazapine is a tetracyclic antidepressant mirtazapine's antagonism of the 5-HT2A and 5-HT2C receptors has beneficial effects on anxiety, sleep and appetite, as well as sexual function regarding the latter receptor.

Hope this helps

Eric


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