Psycho-Babble Medication Thread 998262

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Provigil and Nuvigil - Long-term effectiveness?

Posted by SLS on September 29, 2011, at 15:21:58

I don't see anyone taking Provigil or Nuvigil long-term to treat depression or the fatigue that accompanies other psychotrics. I have seen some people get an energy boost frome these drugs early in treatment, but for one reason or another, they stop taking them. A friend of mine experienced this response pattern recently with Nuvigil.

Is anyone benefiting from one of these drugs with consistency?


- Scott

 

Re: Provigil and Nuvigil - Long-term effectiveness?

Posted by pedr on September 29, 2011, at 15:56:51

In reply to Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 29, 2011, at 15:21:58

nope, I found that after a month of very robust response on 200mg, I started to feel flatter and more tired than before I started taking it. I too haven't heard any long-timers on it.

Pete

------------------
I love the smell of Nardil in the morning. The smell, you know that chemical smell. Smells like victory. Some day this war's gonna end...

 

Re: Provigil and Nuvigil - Long-term effectiveness? » SLS

Posted by Phillipa on September 29, 2011, at 18:01:27

In reply to Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 29, 2011, at 15:21:58

Scott one poster from a while back have on facebook. Husband got addicted to it and She takes it as she can stay awake for hours on it. But she said now she is basically med free. Was also a nardil user. Phillipa

 

Re: Provigil and Nuvigil - Long-term effectiveness?

Posted by Dinah on September 29, 2011, at 18:50:09

In reply to Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 29, 2011, at 15:21:58

I've taken Provigil for years. One in the morning, another 1/2 or one during the day if needed. For daytime sleepiness.

I'm not altogether certain that the morning pill does help me anymore, but if I don't take it, I'm guaranteed to fall asleep. I'm dependent I think.

The extra does help with wakefulness. But just wakefulness. I notice no other effect than that it keeps me from sleeping in the daytime. It won't stop me from sleeping when I should be sleeping.

 

Re: Provigil and Nuvigil - Long-term effectiveness? » SLS

Posted by Bob on September 29, 2011, at 23:05:32

In reply to Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 29, 2011, at 15:21:58

> I don't see anyone taking Provigil or Nuvigil long-term to treat depression or the fatigue that accompanies other psychotrics. I have seen some people get an energy boost frome these drugs early in treatment, but for one reason or another, they stop taking them. A friend of mine experienced this response pattern recently with Nuvigil.
>
> Is anyone benefiting from one of these drugs with consistency?
>
>
> - Scott


I never got much help at all from Provigil an I don't remember trying Nuvigil. I have tried meds like Ritalin and Welbutrin, both of which helped me a great deal in the beginning and then not much at all, and then they eventually seemed to do more harm than good. Successive trials of these meds reduced the initial good response until it was almost non-existent.

Bob

 

Re: Provigil and Nuvigil - Long-term effectiveness?

Posted by creepy on September 30, 2011, at 1:02:30

In reply to Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 29, 2011, at 15:21:58

Seems like every drug that works on dopamine suffers from the same thing. an initial boost followed by eventual poop-out.
What is it about dopamine in the brain that seems to be in a feedback loop, versus serotonin? You dont see nearly as many SSRIs pooping out so quickly.
If the brain re-adjusts to higher levels of a neurotransmitter, why does tinkering with serotonin work so well for so many?
If anyone has a link to info on this Id be interested to check it out.

 

Re: Provigil and Nuvigil - Long-term effectiveness? » creepy

Posted by Bob on September 30, 2011, at 1:42:58

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by creepy on September 30, 2011, at 1:02:30

> Seems like every drug that works on dopamine suffers from the same thing. an initial boost followed by eventual poop-out.
> What is it about dopamine in the brain that seems to be in a feedback loop, versus serotonin? You dont see nearly as many SSRIs pooping out so quickly.
> If the brain re-adjusts to higher levels of a neurotransmitter, why does tinkering with serotonin work so well for so many?
> If anyone has a link to info on this Id be interested to check it out.
>


Yes, the brain's adaptation to our therapeutic efforts seem to quite a foil to efforts to treat mental illness in certain cases. I wish a way to "reset" the brain could be found.

 

Re: Provigil and Nuvigil - Long-term effectiveness? » Bob

Posted by SLS on September 30, 2011, at 6:09:28

In reply to Re: Provigil and Nuvigil - Long-term effectiveness? » creepy, posted by Bob on September 30, 2011, at 1:42:58

> > Seems like every drug that works on dopamine suffers from the same thing. an initial boost followed by eventual poop-out.
> > What is it about dopamine in the brain that seems to be in a feedback loop, versus serotonin? You dont see nearly as many SSRIs pooping out so quickly.
> > If the brain re-adjusts to higher levels of a neurotransmitter, why does tinkering with serotonin work so well for so many?
> > If anyone has a link to info on this Id be interested to check it out.
> >
>
>
> Yes, the brain's adaptation to our therapeutic efforts seem to quite a foil to efforts to treat mental illness in certain cases. I wish a way to "reset" the brain could be found.


A true reset might involve gene therapy. I hope this comes sooner than later.


- Scott

 

Re: Provigil and Nuvigil - Long-term effectiveness? » creepy

Posted by floatingbridge on September 30, 2011, at 8:48:14

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by creepy on September 30, 2011, at 1:02:30

Creepy, I didn't think porvigil worked much on dopamine. I thought it's mechanism was considered slightly mysterious.

 

Re: Provigil and Nuvigil - Long-term effectiveness?

Posted by rjlockhart04-08 on September 30, 2011, at 18:09:15

In reply to Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 29, 2011, at 15:21:58

Nuvigel lifed my mood. My doctor gave it to me when it first came out. The best dose is 250mg. It lifts the mood not quite like amphetamine but it indirectly gives energy. It doest directly release nuerotransmitters but that's part of its job. Its like coffee with out the jitters and more energy.

 

Re: Provigil and Nuvigil - Long-term effectiveness?

Posted by SLS on September 30, 2011, at 18:47:52

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by rjlockhart04-08 on September 30, 2011, at 18:09:15

> Nuvigel lifed my mood. My doctor gave it to me when it first came out. The best dose is 250mg. It lifts the mood not quite like amphetamine but it indirectly gives energy. It doest directly release nuerotransmitters but that's part of its job. Its like coffee with out the jitters and more energy.

You still take it then?


- Scott

 

Re: Provigil and Nuvigil - Long-term effectiveness? » rjlockhart04-08

Posted by Phillipa on September 30, 2011, at 18:48:24

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by rjlockhart04-08 on September 30, 2011, at 18:09:15

Matt have heard it can become addictive for some? Phillipa

 

SLS and Phillipa

Posted by rjlockhart04-08 on September 30, 2011, at 20:26:09

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by SLS on September 30, 2011, at 18:47:52

I took it in 2010 and then I went off it when I went on Vyvnase. I should still be taking Vyvanse but my mother stopped it when she saw me abuse it again. It's really not fair but when I get on my own and make my own doctors appoinments...then i will be free to try a stimulant again.

Until them...its gonna be hard to keep a job.

 

Re: SLS and Phillipa » rjlockhart04-08

Posted by Bob on September 30, 2011, at 20:57:34

In reply to SLS and Phillipa, posted by rjlockhart04-08 on September 30, 2011, at 20:26:09

> I took it in 2010 and then I went off it when I went on Vyvnase. I should still be taking Vyvanse but my mother stopped it when she saw me abuse it again. It's really not fair but when I get on my own and make my own doctors appoinments...then i will be free to try a stimulant again.
>
> Until them...its gonna be hard to keep a job.


So Vyvanse successfully treated your depressed mood as well as giving you energy?

Bob

 

Re: Provigil and Nuvigil - Long-term effectiveness?

Posted by creepy on October 1, 2011, at 0:28:03

In reply to Re: Provigil and Nuvigil - Long-term effectiveness? » creepy, posted by floatingbridge on September 30, 2011, at 8:48:14

Supposedly it works on histamine and dopamine. It binds to some dopamine receptors doing -something- but no one knows quite what.

 

Re: Provigil and Nuvigil - Long-term effectiveness? » creepy

Posted by floatingbridge on October 1, 2011, at 0:32:34

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by creepy on October 1, 2011, at 0:28:03

Oh, histamine. Maybe that is why I disliked it so. Thanks creepy.

 

Re: Provigil and Nuvigil - Long-term effectiveness? » creepy

Posted by SLS on October 1, 2011, at 7:04:28

In reply to Re: Provigil and Nuvigil - Long-term effectiveness?, posted by creepy on October 1, 2011, at 0:28:03

Orexin (hypocretin) is a wakefulness-promoting peptide that acts as a neurotransmitter. Provigil and Nuvigil both act to stimulate orexineric neurons. There are studies that also report that these drugs bind to and block dopamine transporters.


- Scott


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