Psycho-Babble Medication Thread 972019

Shown: posts 1 to 10 of 10. This is the beginning of the thread.

 

Protein may hold the key to new AD treatments

Posted by Tomatheus on November 30, 2010, at 23:09:11

Neurological protein may hold the key to new treatments for depression

Nov. 29, 2010 (Toronto) -- Neuroscientists at the Centre for Addiction and Mental Health (CAMH) have developed a protein peptide that may be a novel type of highly targeted treatment for depression with a low side-effect profile. Depression affects one in ten Canadians at some time in their lives and is a leading cause of disability worldwide.

The study published in this month's Nature Medicine found that coupling between two dopamine receptors was significantly elevated in the brains of people who had been diagnosed with major depression.

"We identified a potential therapeutic target for development of novel anti-depressants." said Dr. Fang Liu, Principal Investigator and Senior Scientist in CAMH's Neuroscience Program and Associate Professor of Psychiatry at the University of Toronto.

Working from this discovery, researchers sought to find a way to disrupt coupling between the two receptors in hopes that it would have an anti-depressant effect.

Using an autopsied brain study, Dr. Liu and her team initially found that coupling between two dopamine receptors was significantly elevated in the brains of people who had been diagnosed with major depression. They started by analyzing a specific dopamine signaling mechanism, the D1 and D2 receptor complex, to identify the sites where the two receptors bind together. With this information, they were able to generate a protein peptide to disrupt the binding of the two receptors. The peptide was then tested in animal models to compare the effects with existing anti-depressant medications.

"After we administered the peptide, we saw a marked improvement in depression-related behaviors. The improvement seen in the peptide group was equivalent to the improvement on traditional anti-depressant medication."

This peptide is an entirely new approach to treating depression, which has previously relied on medications that primarily block serotonin or norepinephrine transporters. These conventional antidepressant medications don't work for all patients, and can cause various side effects.

"We are hopeful that our research will lead to new options for treatment that might have reduced side effects for patients with depression," Dr Liu stated.

Source:
http://www.camh.net/News_events/News_releases_and_media_advisories_and_backgrounders/Fang_liu_dopamine_coupling.html

 

Yeah! Love to hear hopeful news about new meds

Posted by FluffMama on December 1, 2010, at 2:12:58

In reply to Protein may hold the key to new AD treatments, posted by Tomatheus on November 30, 2010, at 23:09:11

Thanks for the post - I love to hear about new meds that are in development. This dopamine stuff makes a lot of sense. I know that in people with Type O blood, there is a problem with dopamine breakdown and the adrenaline system, so this is right on track with what other science is showing us.

 

Re: Yeah! Love to hear hopeful news about new meds » FluffMama

Posted by Phillipa on December 1, 2010, at 10:23:34

In reply to Yeah! Love to hear hopeful news about new meds, posted by FluffMama on December 1, 2010, at 2:12:58

I don't understand this blood typing especially if type O is universal and can be given with any other type blood A, B, AB, or O I think. So does that mean a transfusion to a type A or one of the others could somehow change mental status. What does type A mean as I don't understand how blood type can predict? Phillipa

 

Re: Yeah! Love to hear hopeful news about new meds

Posted by FluffMama on December 1, 2010, at 13:02:47

In reply to Re: Yeah! Love to hear hopeful news about new meds » FluffMama, posted by Phillipa on December 1, 2010, at 10:23:34

> I don't understand this blood typing especially if type O is universal and can be given with any other type blood A, B, AB, or O I think. So does that mean a transfusion to a type A or one of the others could somehow change mental status. What does type A mean as I don't understand how blood type can predict? Phillipa

Phillipa, see my new post about Depression/Stress and your Blood Type. It gives a simple explanation. Blood type O is a universal donor but that has nothing to do with different blood types and their individual genetic profiles.

 

Re: Protein may hold the key to new AD treatments

Posted by bleauberry on December 1, 2010, at 19:11:09

In reply to Protein may hold the key to new AD treatments, posted by Tomatheus on November 30, 2010, at 23:09:11

If I had seen this on Facebook I would be clicking the "like" button.

 

Re: Yeah! Love to hear hopeful news about new meds » FluffMama

Posted by Phillipa on December 1, 2010, at 20:42:42

In reply to Re: Yeah! Love to hear hopeful news about new meds, posted by FluffMama on December 1, 2010, at 13:02:47

Yes I see you have posted it. I seriously wish you would babblemail me as told today by a pharmacist that my brain has been so damaged over the years there is no cure as I'm old almost 65. And since age 24 with first panic attack been on benzos and much more. I want help I will post a thread doubt anyone will respond. But don't know what else to do. Phillipa

 

Phillipa - what is BabbleMail?

Posted by FluffMama on December 2, 2010, at 0:40:06

In reply to Re: Yeah! Love to hear hopeful news about new meds » FluffMama, posted by Phillipa on December 1, 2010, at 20:42:42

> Yes I see you have posted it. I seriously wish you would babblemail me as told today by a pharmacist that my brain has been so damaged over the years there is no cure as I'm old almost 65. And since age 24 with first panic attack been on benzos and much more. I want help I will post a thread doubt anyone will respond. But don't know what else to do. Phillipa

First of all, I'm afraid I'm too new - I don't know what Babblemail is! Secondly, don't ever believe someone that tells you the human body is damaged beyond repair and that there is no cure! 65 is YOUNG! Thirdly, don't listen to a mere Pharmacist - where is the M.D. behind their name? They like to sound important and they do know about medications, but only a doctor can tell you there is no hope, and a Naturopath will probably never tell you that. Our capacity to grow new neurons and all that stuff is remarkable. Bah Humbug. Don't listen to a word of it.

What is it you are trying to cure? I think that if you have anxiety or depression there may not be a CURE for it yet, but treatment that makes it manageable. Why does the pharmacist (and yourself) think your brain is damaged? Do you have trouble remembering things? Or are you trying to get relief and nothing is working right now? That just means you haven't found what works yet, and you know how complicated these things are. How dare the pharmacist tell you how damaged your brain is. I know brilliant drug abusers from the 1960's that tried ALL KINDS of destructive stuff and they are fine today. So your brain isn't going to be ruined or "hopeless" just because you took some benzos! That pharmacist is WAY out of his/her league and did they run a brain scan on you? NO!

 

Re: Phillipa - what is BabbleMail? » FluffMama

Posted by Phillipa on December 2, 2010, at 18:45:03

In reply to Phillipa - what is BabbleMail?, posted by FluffMama on December 2, 2010, at 0:40:06

FluffMama a babblemail is sent from this site to the recipient like an e-mail. No one reads but the writers. Used to be go to registration and click on want babblemail. And if you look at my name it's probably blue. You click on the blue name and a screen appears where you type a personal message then if you desire a copy click at the top. But to send it go to bottom and click send. See my name is blue try clicking on it and then see if you would like your own on. Phillipa

 

Re: Facebook button

Posted by Dr. Bob on December 4, 2010, at 22:19:37

In reply to Re: Protein may hold the key to new AD treatments, posted by bleauberry on December 1, 2010, at 19:11:09

> If I had seen this on Facebook I would be clicking the "like" button.

You could can the "share" button here...

Bob

 

Re: what is BabbleMail?

Posted by Dr. Bob on December 4, 2010, at 22:20:56

In reply to Re: Phillipa - what is BabbleMail? » FluffMama, posted by Phillipa on December 2, 2010, at 18:45:03

> FluffMama a babblemail is sent from this site to the recipient like an e-mail. No one reads but the writers. Used to be go to registration and click on want babblemail. And if you look at my name it's probably blue. You click on the blue name and a screen appears where you type a personal message then if you desire a copy click at the top. But to send it go to bottom and click send. See my name is blue try clicking on it and then see if you would like your own on.

Thanks for explaining. More information is at:

http://www.dr-bob.org/babble/faq.html#babblemail

Bob


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