Psycho-Babble Medication Thread 913858

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Will 50mg Amitriptyline -) 50mg Nortriptyline?

Posted by linkadge on August 24, 2009, at 10:34:23

When amitriptyline converts to nortiptyline can one expect the same blood level of nortriptyline as with an equivalent dose of nortriptyline?

I.e would 50mg of amitriptyline eventually produce the same blood level of nortriptyline as 50mg of nortriptyline?

If so, wouldn't the theraptutic dose of amitriptyline be lower as you essentually have two AD's in the system?

Linkadge

 

Re: Will 50mg Amitriptyline -) 50mg Nortriptyline?

Posted by bulldog2 on August 24, 2009, at 11:16:29

In reply to Will 50mg Amitriptyline -) 50mg Nortriptyline?, posted by linkadge on August 24, 2009, at 10:34:23

o> When amitriptyline converts to nortiptyline can one expect the same blood level of nortriptyline as with an equivalent dose of nortriptyline?
>
> I.e would 50mg of amitriptyline eventually produce the same blood level of nortriptyline as 50mg of nortriptyline?
>
> If so, wouldn't the theraptutic dose of amitriptyline be lower as you essentually have two AD's in the system?
>
> Linkadge

No. I read that 2 milligrams of amitriptyline equals 1 milligram of nortriptyline in terms of the therapeutic window. Maybe each milligram of amitriptyline only produces a minute amount of nortriptyline. Just speculating. Can only tell you what I read.

 

Re: Will 50mg Amitriptyline -) 50mg Nortriptyline? bulldog2

Posted by Phillipa on August 25, 2009, at 10:31:20

In reply to Re: Will 50mg Amitriptyline -) 50mg Nortriptyline?, posted by bulldog2 on August 24, 2009, at 11:16:29

Bulldog any links to the study? Phillipa


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