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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by morganator on August 23, 2009, at 23:21:31
Scott, I am considering dumping Zoloft and starting Parnate 2 weeks later. I am also considering trying Agomelatine. Do you think Ago and Parnate would be a dangerous mix??? I guess I could just go ahead and combine Nortriptyline with Parnate if it helps with sleep.
Gayle, You said that you have not felt this good in 15 years. Would you contribute this more to Parnate or Nortriptyline or both. After reading yours post, it appears that it may be more due to the Parnate.
Scott, I know I have asked this question recently so please try not to be annoyed. Do you know of anyone that only doses Parnate one time in the morning? I'm sorry I should have read through the archives. Honestly I'm just being lazy.
Morgan
Posted by morganator on August 24, 2009, at 0:06:15
In reply to To ColoradoSnowflake and SLS, posted by morganator on August 23, 2009, at 23:21:31
Scott, one more quick question, do you know if Parnate and Nardil have been shown to promote neurogenesis in the same areas that other antidepressants do? I am assuming they do.
Posted by morganator on August 24, 2009, at 0:28:38
In reply to Re: To ColoradoSnowflake and SLS, posted by morganator on August 24, 2009, at 0:06:15
If anyone can answer the questions posed to Scott that would be great
Posted by ColoradoSnowflake on August 24, 2009, at 1:34:58
In reply to Re: To Anyone about Parnate » morganator, posted by morganator on August 24, 2009, at 0:28:38
Hi Morgan:
Just a quick note on my way to bed.
I think the "Magic" for me is in the synergism of Parnate and Nortrip. The Parnate didn't feel good until I started the Nortrip. I took Nortrip a while back with Wellbutrin and it made me so hungry I couldn't take it. It doesn't do that with the Parnate.The Parnate/Nortrip is smooth...no side effects except some dry mouth which I think might go away.
In terms of dosing, I am still experimenting. I have been afraid to take Parnate after 3pm for fear it would keep me awake. A couple of nights ago I forgot the Parnate until 10pm. I usually take nortrip at 6pm. Eeeeeks. I didn't know what to do. I am under so much stress right now until this stupid trial is over, so I decided I needed it in my system even if it kept me awake all night. Low and behold I took the Parnate30mg and the Nortrip. at 10pm and I went to bed at midnight and went right to sleep, the whole night!!
I can tell you also that as soon as the time comes to take Parnate, if I forget I start feeling bad, down, depressed. When I take it I perk right up again. ???? I don't really understand it yet but I am experimenting.
I also went up to 60mg Parnate, at least until the trial is over. I can tell I need it.
Still, never any trouble sleeping. Yippee! I have ALWAYS had insomnia. Not now!! And I take the full amount of Provigil everyday, also.
That's all I can tell you about Parnate/Nortrip and me at this point.
I feel like I had a really good "washout" before I started Parnate and I'm glad. It was kind of rough for me at first.
Hugs,
Gayle
Posted by SLS on August 24, 2009, at 6:28:07
In reply to To ColoradoSnowflake and SLS, posted by morganator on August 23, 2009, at 23:21:31
> Scott, I am considering dumping Zoloft and starting Parnate 2 weeks later. I am also considering trying Agomelatine. Do you think Ago and Parnate would be a dangerous mix??? I guess I could just go ahead and combine Nortriptyline with Parnate if it helps with sleep.
I am hoping that agomelatine will be safe to mix with MAOIs. I would try it myself. "On paper", I don't see any unsafe pharmacological interactions. However, in real life, who knows? We don't know everthing about these drugs. Does the stimulation of melatonin receptors cause a release of serotonin downstream? I don't know.
> Scott, I know I have asked this question recently so please try not to be annoyed. Do you know of anyone that only doses Parnate one time in the morning? I'm sorry I should have read through the archives. Honestly I'm just being lazy.
I know the feeling. No problem.
I do not believe that once a day dosing of Parnate is sufficient to maintain a steady inhibition of MAO. Whenever I have tried it, I experienced REM rebound at night. REM rebound and vivid dreaming are reliable indexes of a loss of MAO inhibition. I take 40mg in the morning and 40mg at 2:00pm. I think this is an optimal schedule.
- Scott
Posted by SLS on August 24, 2009, at 6:31:32
In reply to Re: To ColoradoSnowflake and SLS, posted by morganator on August 24, 2009, at 0:06:15
> Scott, one more quick question, do you know if Parnate and Nardil have been shown to promote neurogenesis in the same areas that other antidepressants do? I am assuming they do.
I think neurogenesis is a function of therapeutic response. Unlike lithium, it will not occur unless there is an antidepressant response. This is what leads me to believe that tissue atrophy is the result of depression rather than its cause.
- Scott
Posted by morganator on August 24, 2009, at 21:46:28
In reply to Re: To ColoradoSnowflake and SLS, posted by SLS on August 24, 2009, at 6:31:32
Thank you both so much for your replies. Yeah I'm not crazy about the 2 time a day dosing. I don't know if I will be disciplined enough. That's too bad more of an effort is not being put into developing better MAOIs. I guess extended release or slow release versions of Parnate or Nardil would not be easy to make? Half life may not apply the same way it does to other antidepressants? Or maybe it does.
This is the end of the thread.
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