Psycho-Babble Medication Thread 913170

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aripiprazole (Abilify) available in Canada?

Posted by iforgotmypassword on August 20, 2009, at 15:42:44

I google and internet pharmacies that seem to imply that what they are selling is canadian in origin, at prices that seem Canadian (~4$ a pill) when compared to the 10+$ a pill in the united states.

Did it become available in Canada at some point?

I am interested in aripiprazole for its 5ht-1a mechanism, which seems not to be underestimated. (~15% occupancy evenly through the 10-30mg dosage range apparently.)

I am interested in trying 1mg (a split 2mg) to see if you can go that low with the drug. An article I came across mentioned even lower (0.675mg) being efficacious in treating levodopa related dyskinesias in parkinson's patients. Very curious.

Here are the articles I am basing my curiosity on:

Differential Effects of Aripiprazole on D2, 5-HT2, and 5-HT1A Receptor Occupancy in Patients With Schizophrenia: A Triple Tracer PET Study
http://ajp.psychiatryonline.org/cgi/content/full/164/9/1411

Aripiprazole in L-dopa-induced dyskinesias: a one-year open-label pilot study.
http://www.ncbi.nlm.nih.gov/pubmed/19533295

In the first article it seems to mention that dopamine receptor occupancy is what diminishes measurably with decreasing dosage (30 down to 10mg at least). It may suggest 5HT-1A and 5HT2 occupancy reach a ceiling somewhere before 10mg, though I don't if 1mg is pushing things a little. I have a feeling the lowest dopamine receptor occupancy would be the best decision for me given my already existent movement issues (including akathisia, parkinson like sx, facial tension and movements, etc, all requiring a lot of lorazepam usage which has so many downsides.) I am trying to treat anhedonic, cognitive, self-care, coordination, rigidity-and-movement-related sx; hoping to recreate my effectively high-dose buspirone response, my most palpable ever, and get continued improvement. I am continuing agomelatine for the time being. Will likely continue 25mg for one more week, then a week of 50mg, if no hint of a developing response is felt, I will drop it and try aripiprazole if it is available here. Still wish I could get my grimy hands on tandospirone tho.

 

seems not, augh. (nm)

Posted by iforgotmypassword on August 20, 2009, at 16:12:11

In reply to aripiprazole (Abilify) available in Canada?, posted by iforgotmypassword on August 20, 2009, at 15:42:44

 

one interesting find however

Posted by iforgotmypassword on August 20, 2009, at 16:27:05

In reply to aripiprazole (Abilify) available in Canada?, posted by iforgotmypassword on August 20, 2009, at 15:42:44

http://phx.corporate-ir.net/phoenix.zhtml?c=60908&p=irol-newsArticle&ID=975763&highlight=

In case this hasn't been mentioned, Barr/Teva is making use of some legal route to try and gain the rights to produce a generic before the patent's expiry, I don't know anything about the actual legal details relating to what they are doing tho.

 

Re: one interesting find however » iforgotmypassword

Posted by SLS on August 20, 2009, at 16:45:55

In reply to one interesting find however, posted by iforgotmypassword on August 20, 2009, at 16:27:05

Is Geodon (ziprasidone) available?

I think doctors are becoming increasingly interested in using Geodon as an augmenter to treat depression.

Is there any history of bipolar spectrum disorders in your family? How do you respond to:

Wellbutrin?
Effexor?
Lexapro?
Parnate?


- Scott

 

Re: seems not, augh. » iforgotmypassword

Posted by maxime on August 20, 2009, at 17:05:58

In reply to seems not, augh. (nm), posted by iforgotmypassword on August 20, 2009, at 16:12:11

It was supposed to be available this July, but as you are aware it's not. I wonder how close we are to getting it?

 

Re: one interesting find however

Posted by iforgotmypassword on August 20, 2009, at 19:08:44

In reply to Re: one interesting find however » iforgotmypassword, posted by SLS on August 20, 2009, at 16:45:55

> Is Geodon (ziprasidone) available?
>
> I think doctors are becoming increasingly interested in using Geodon as an augmenter to treat depression.
>
> Is there any history of bipolar spectrum disorders in your family? How do you respond to:
>
> Wellbutrin?
> Effexor?
> Lexapro?
> Parnate?
>
>
> - Scott

Unfortunately, I don't respond to any of those. I have responded to wellbutrin before but only once and it wore off. Any other attempts with it did not work. In case this helps illustrate it, I find lamotrigine more stimulating.

Parnate plainly did not work. once when I took desipramine and parnate together on a desperate impulse, I had a response, I'm not sure it would have been a response I would have tolerated 24/7 tho, and my doctor would never officially rx such a combo.

Atypical depression causing severe inertia, anhedonia, neurosis, alcoholism, and unreliable cognition would be something that my mother may have made up my mother's diagnosis with if she had sought help. She had epilepsy that was once treated and her seizures did not come back. She nearly never worked, I'd say most days of the year she didn't even get dressed, bedridden would have described my mother's life fairly well. I do not know anyone else biologically related to her. I have wondered if similar illness forced her biological parents to put her up for adoption.

My Dad's side is strange. Parkinson's runs in my Dad's family, he now has it; but life patterns suggesting weak dopaminergic function are present in many of my relatives.

My paternal grandmother almost unquestionably has a very severe personality disorder, not borderline, more narcissistic, and to the point of completely irrational grandiose thinking. Also never worked. Hired immigrants to take care of her children, while she drank, had parties, and pretended she was famous. Not at all making this up, she somehow managed to get herself into the newspaper on several occasions, all based on complete b*llsh*t she made up. She was on the front page of the Citizen with her arms around Paul Martin's neck when he was Prime Minister. She thinks we should be paying to have her live in the Chateau Laurier for the rest of her life. There's no "action" where she's living now. Alcoholic throughout her entire life, extremely emotionally abusive, impossible to be around.

Anyway, I have no idea what this would spell out, but there are enough examples in my family to really make me worry about my genes.

 

Re: seems not, augh. » maxime

Posted by iforgotmypassword on August 20, 2009, at 19:13:00

In reply to Re: seems not, augh. » iforgotmypassword, posted by maxime on August 20, 2009, at 17:05:58

The pharmacist at my pharmacy said she thought she heard something, but she didn't remember off-hand. That may have been it, the potential July date maybe, where did you hear it?

I have no knowledge on what decides these matters.

 

Re: one interesting find however » iforgotmypassword

Posted by Phillipa on August 21, 2009, at 0:41:13

In reply to Re: one interesting find however, posted by iforgotmypassword on August 20, 2009, at 19:08:44

I'm so sorry sounds like you've had a rough life as well. Were you well as a child? What age did your symtoms start at? You don't also drink do you? Love Phillipa

 

Re: seems not, augh. » iforgotmypassword

Posted by maxime on August 22, 2009, at 17:34:21

In reply to Re: seems not, augh. » maxime, posted by iforgotmypassword on August 20, 2009, at 19:13:00

I heard it from someone who friend was drug rep. for the med. I remember that Cymbalta came out much later than orginally planned in Canada. Maybe it's a trend.


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