Psycho-Babble Medication Thread 895198

Shown: posts 1 to 14 of 14. This is the beginning of the thread.

 

Tryciclics SSRIs and MAOIs + receptors

Posted by meltingpot on May 11, 2009, at 15:07:29

Hi,

Well I'm still taking this clomipramine, anxiety is not so bad but I'm just dragging myself around from day to day. Constantly fatigued, inspite of getting 10 hours sleep a night.

My question is this. I would be prepared to suffer this out for a year on Clomipramine if I thought that by staying off Seroxat for a year then it might actually work again if I go back on it for a year.

I tried coming off Seroxat for about 2 months and going back on it and it still didn't work so not sure if staying off it a year would make any difference.

I'm not sure why the Seroxat stopped working after two years, either my depression has just got worst and I've become more resistant than ever or somehow seroxat did something that had an adverse affect after a period of time which maybe could be undone after a period of time.

I'm just clutching at straws again, does anyone have any ideas on this?


Thanks......Denise

 

Re: Tryciclics SSRIs and MAOIs + receptors » meltingpot

Posted by Phillipa on May 11, 2009, at 21:33:00

In reply to Tryciclics SSRIs and MAOIs + receptors, posted by meltingpot on May 11, 2009, at 15:07:29

This actually just clicked in my mind when read your thread. I wonder if ad's are like antibiotics and you become resistant. Like the brain is used to the med like a bacteria would be used to the antibiotic and hence no longer work? I wonder. Love Phillipa

 

Re: Tryciclics SSRIs and MAOIs + receptors » meltingpot

Posted by sowhysosad on May 11, 2009, at 22:00:42

In reply to Tryciclics SSRIs and MAOIs + receptors, posted by meltingpot on May 11, 2009, at 15:07:29

Do you think dopamine could be the issue here? As in depleted dopamine or a slowed firing rate due to the long-term seroxat?

I think that was my problem when I came off an SSRI and later switched to a similar tricyclic (imipramine). The tricyclic didn't seem to address the dopamine issue and somehow made the depression more profound through some mechanism (anticholinergic maybe?).

When I phased out the tricyclic and started taking a dopaminergic supplement instead I started on the road to remission within 5 days and, a few weeks on, continue to improve.

Like you, I slept WAY too much on the tricyclic and yet felt constantly tired. Possibly a dopamine issue too.

> Hi,
>
> Well I'm still taking this clomipramine, anxiety is not so bad but I'm just dragging myself around from day to day. Constantly fatigued, inspite of getting 10 hours sleep a night.
>
> My question is this. I would be prepared to suffer this out for a year on Clomipramine if I thought that by staying off Seroxat for a year then it might actually work again if I go back on it for a year.
>
> I tried coming off Seroxat for about 2 months and going back on it and it still didn't work so not sure if staying off it a year would make any difference.
>
> I'm not sure why the Seroxat stopped working after two years, either my depression has just got worst and I've become more resistant than ever or somehow seroxat did something that had an adverse affect after a period of time which maybe could be undone after a period of time.
>
> I'm just clutching at straws again, does anyone have any ideas on this?
>
>
> Thanks......Denise

 

Re: Tryciclics SSRIs and MAOIs + receptors

Posted by desolationrower on May 13, 2009, at 10:11:10

In reply to Tryciclics SSRIs and MAOIs + receptors, posted by meltingpot on May 11, 2009, at 15:07:29

> Hi,
>
> Well I'm still taking this clomipramine, anxiety is not so bad but I'm just dragging myself around from day to day. Constantly fatigued, inspite of getting 10 hours sleep a night.
>
> My question is this. I would be prepared to suffer this out for a year on Clomipramine if I thought that by staying off Seroxat for a year then it might actually work again if I go back on it for a year.
>
> I tried coming off Seroxat for about 2 months and going back on it and it still didn't work so not sure if staying off it a year would make any difference.
>
> I'm not sure why the Seroxat stopped working after two years, either my depression has just got worst and I've become more resistant than ever or somehow seroxat did something that had an adverse affect after a period of time which maybe could be undone after a period of time.
>
> I'm just clutching at straws again, does anyone have any ideas on this?
>
>
> Thanks......Denise

Hi, sounds like you are out of hope :(

I wonder if taking a drug that is an snri is going to keep you from having 5ht receptors 'reset'...the only thing i can think of would be either inositol or tianeptine or SAMe, its possible they might 'reset' things (and be helpful now too) since they all 'improve' 5htergic function in one way or another, although i don't have any evidence really they reset things (and its more likely they'd work now, than that they'd not work but make seroxat work 6mo from now, i think).

-d/r

 

Re: Tryciclics SSRIs and MAOIs - Phillipa

Posted by Meltingpot on May 14, 2009, at 11:11:32

In reply to Re: Tryciclics SSRIs and MAOIs + receptors » meltingpot, posted by Phillipa on May 11, 2009, at 21:33:00

Hi Phillipa,

I hope not and I my gut feeling is that is not the case. But then what do I know :-)

Denise

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad

Posted by Meltingpot on May 14, 2009, at 11:14:53

In reply to Re: Tryciclics SSRIs and MAOIs + receptors » meltingpot, posted by sowhysosad on May 11, 2009, at 22:00:42

Hi,

I'm hoping that you've hit the nail on the head and that it is dopamine that is the issue here, at least then I will have some kind of explanation.

But please don't tell me that the dopamine supplement that put you into remission was some kind of health supplement like L-Tyrosine. I've already tried that (only for a week or so) and it didn't seem to do anything.

What dopamine supplement helped you and how long did you have to take it for before you felt the affects?


Thanks......Denise

 

Re: Tryciclics SSRIs and MAOIs to D/R

Posted by Meltingpot on May 14, 2009, at 11:19:00

In reply to Re: Tryciclics SSRIs and MAOIs + receptors, posted by desolationrower on May 13, 2009, at 10:11:10

Hi D/R,

I hope I'm not out of hope, I really do.

Thanks for your suggestion but I tried Tieneptine and inositol and neither of them seemed to do anything at all.

Thanks for the suggestions though.


Denise

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad » Meltingpot

Posted by sowhysosad on May 14, 2009, at 21:08:59

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad, posted by Meltingpot on May 14, 2009, at 11:14:53

> But please don't tell me that the dopamine supplement that put you into remission was some kind of health supplement like L-Tyrosine. I've already tried that (only for a week or so) and it didn't seem to do anything.
>
> What dopamine supplement helped you and how long did you have to take it for before you felt the affects?

I'm afraid so Denise! It's NADH that seems to be helping. I noticed a perceptible difference within a few days. Other dopaminergics like codeine and nicotine seem to have an effect too.

It's by no means a miracle cure and there's a fine line between an antidepressant effect and overstimulation, but I'm functioning on some level approximating normality now after months in a very dark place.

I'm also taking 200mg of 5htp per day to balance things out, as I understand taking dopaminergic or serotonergic supplements in isolation can negatively affect levels of the other neurotransmitter.

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad

Posted by Meltingpot on May 17, 2009, at 7:36:18

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad » Meltingpot, posted by sowhysosad on May 14, 2009, at 21:08:59

Hi,

What is NADH, I've never heard of it? What made you try it and where do you buy it from?

Have you also tried L-Tyrosine and other supplements?

Are you sure you are not feeling better solely because of coming off the tryciclic?

Thanks....Denise

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad

Posted by sowhysosad on May 17, 2009, at 17:16:16

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad, posted by Meltingpot on May 17, 2009, at 7:36:18

> What is NADH, I've never heard of it? What made you try it and where do you buy it from?

It's a co-enzyme of vitamin B6 I believe. It's stimulating and it's claimed it raises dopamine levels in the brain. eBay seems to be the cheapest option in the UK (IIRC you're British, aren't you?).

> Have you also tried L-Tyrosine and other supplements?

I was contemplating trying it next by way of comparison. I also take 5-HTP but am struggling to get the dose right - I'm suffering anxiety very similar to SSRI startup effects.

> Are you sure you are not feeling better solely because of coming off the tryciclic?

Could well be Denise. As time goes on I seem to be slowly getting worse again and it could well be the supplements that are doing it, but who knows? My psychiatrist doesn't want to start me on a new med so I'm stuck at the mo.

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad

Posted by Meltingpot on May 21, 2009, at 10:48:32

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad, posted by sowhysosad on May 17, 2009, at 17:16:16

Hi,

Thanks for that information, you are right I am in the UK. I might give it a try. I have to say I'm highly sceptical of supplements as none of them have ever worked for me, having said that, I never give them very long.

I'm just always sceptical when people say that they feel something within a few days of taking a supplement as that has never happened to me but then we are all different.

I'm sorry to hear you are starting to feel worse, why won't your psychiatrist prescribe a medication??

Denise

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad » Meltingpot

Posted by sowhysosad on May 22, 2009, at 6:24:00

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad, posted by Meltingpot on May 21, 2009, at 10:48:32

> Thanks for that information, you are right I am in the UK. I might give it a try. I have to say I'm highly sceptical of supplements as none of them have ever worked for me, having said that, I never give them very long.

Yeah, maybe give it 4 weeks or so unless you feel worse and then make a decision.

> I'm sorry to hear you are starting to feel worse, why won't your psychiatrist prescribe a medication??

I'm very busy helping a friend out with a new business and the pdoc was concerned that the start-up side effects from a new med might interfere with my ability to function. He also thought it might cause a relapse in my movement disorder which has greatly improved after quitting AD's.

Some days - when my mood is good - I think it was a good call. Part of me thinks I need to purge my body of meds for a while and let my brain return to baseline. Other days are a real struggle and I wonder if an AD would help!

Still, I'm seeing him again in 3 weeks so we'll see how I am then.

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad

Posted by Meltingpot on May 22, 2009, at 13:15:18

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad » Meltingpot, posted by sowhysosad on May 22, 2009, at 6:24:00

Hi,

Ok, well it's good that you can review things in 3 weeks time. Just try and keep your mind on setting up this new business then. Although I know how hard it can be to keep your mind on anything the more depression and anxiety gets a hold.

Denise

 

Re: Tryciclics SSRIs and MAOIs - to Sowhysosad

Posted by sowhysosad on May 23, 2009, at 7:59:48

In reply to Re: Tryciclics SSRIs and MAOIs - to Sowhysosad, posted by Meltingpot on May 22, 2009, at 13:15:18

Thanks Denise!

My main issues at the moment are early awakening then morning crying spells, depression and anxiety. Often I improve a lot during the day and have some genuinely good moods, presumably in part due to to keeping busy.

But considering that a matter of weeks ago - whilst medicated on imipramine - I was sleeping 16 hours a day and barely able to talk to another human being, I can't complain too much really!

I'm finding a "Psychology of Mind" self-help book by the late Richard Carlson helps a lot too in the absence of meds - it teaches you the skills to avoid those trains of thought that perpetuate your depression.

> Hi,
>
> Ok, well it's good that you can review things in 3 weeks time. Just try and keep your mind on setting up this new business then. Although I know how hard it can be to keep your mind on anything the more depression and anxiety gets a hold.
>
> Denise


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