Psycho-Babble Medication Thread 891025

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Re: Effects of long term SSRI use... My Story...

Posted by linkadge on April 18, 2009, at 20:03:06

In reply to Re: Effects of long term SSRI use... My Story... » Jay_Bravest_Face, posted by linkadge on April 18, 2009, at 19:54:08

Yes, there is plenty of evidence that these medicatiosn are less than perfect. But, unfortunately when the issue is brought up some people just happen to lose their jobs (eg. David Healey).


Linkadge

 

Re: Effects of long term SSRI use... My Story...

Posted by linkadge on April 18, 2009, at 20:13:44

In reply to Re: Effects of long term SSRI use... My Story..., posted by garnet71 on April 18, 2009, at 1:24:44

Mental illness *can* be progressive, but there is certainly no proof that this is the case with all patients.

Some people who have reacted adversley to long term SSRI use complain of symptoms that:

a) they never had before taking the medication
b) are not symptoms typically associated with
depression
c) Resolve upon reinsitution of the drug

Another thing that bothers me is that in most other areas of medicine, the patient's experience is generally respected.

I honestly believe however, that the advacement of psychiatry is significantly hindered by the fact that the patient's experiences are often shrugged off as "the underlying disorder".

It only took us like 20 years after SSRI's were introduced for there to be a medical agreement that the drugs can produce *withdrawl symptoms* (and they're still not called withdrawl symptoms for some strange reason)

That being said, I'm sure there are tons of other less common adverse reactions that will never see the light of day for the same reasons.

Linkadge

 

Re: Effects of long term SSRI use... My Story... » linkadge

Posted by Garnet71 on April 18, 2009, at 20:32:01

In reply to Re: Effects of long term SSRI use... My Story..., posted by linkadge on April 18, 2009, at 20:13:44

Oh sorry Linkadge, I meant late onset (as opposed to progressive). not that it makes much of an argument, just thinking out loud. I mean most anyone I knew with mental health issues, such as family members who got phobias, anxieties, schitozphrenia, etc, developed these things later in life, late 20s and early 30s.

Anway I tend to agree that new symptoms would just be attributed to the underlying disorder. But how could you prove what causes the symptoms? You said an AD will cease symptoms--so anyone could argue that is because the AD is working. Now i'm confused. what am I saying. Never mind!

 

Re: Effects of long term SSRI use... My Story...

Posted by 4ed on April 18, 2009, at 23:42:02

In reply to Re: Effects of long term SSRI use... My Story... » linkadge, posted by Garnet71 on April 18, 2009, at 20:32:01

Let me go out on a limb and tell you all... I was better off taking some MDMA, Ketamine, or Psiylocybin, on occasion. a single dose comibined with accompanying positive set and setting, fixed me for a good while off a single dose. maybe this knowledge makes me look at prescribed med treatment as a long term 50% effective treatment compared to these magical experiences that left me with a lust for life for many months after a single dose. maybe thats why they are all class 1 conrolled substances... they are too effective! And one dose your done... you might not even care to do it again and become an "addict"... these are not cocaine or heroin, a good trip last a good while, perhaps a lifetime... only for the headstrong? sorry if my comments are a little left wing. but I've given western pharmaceuticals their fair chance and its just not happening. 'cept for Xanax -- the ultimate bliss pill.

 

Re: Effects of long term SSRI use... My Story... » newquestions

Posted by garnet71 on April 18, 2009, at 23:44:18

In reply to Effects of long term SSRI use... My Story..., posted by newquestions on April 16, 2009, at 9:10:07

OldQuestions,

"I stopped listening to music or watching movies because I can't enjoy them or anything else anymore. What really concerns me is the cognitive decline. I just can't think abstractly anymore. I can't learn. My attention to detail sucks."

Although I've had various ADD symptoms to contend with prior to anxiety/depression, I've experienced the same symptoms from SSRIs that you report. Although unlike you, as soon as I quit them, those symptoms greatly improved-but I have yet to get back to 'normal' especially in terms of cognition, motivation. I'm having some enjoyment of life issues, but not too bad since my mood is generally stable (aside from anxiety issues).

You're not going to like this--but I think you should try a new med combo - sans xxRIs. Adderall somehow works on dopamine - I felt so much more normal on that, but couldn't take it for other reasons.

I think you should try Provigil. I mean, look at it this way - what have you got to lose now???????

 

Re: Effects of long term SSRI use... My Story... » newquestions

Posted by garnet71 on April 18, 2009, at 23:45:02

In reply to Effects of long term SSRI use... My Story..., posted by newquestions on April 16, 2009, at 9:10:07

....or Segeline

 

Re: Effects of long term SSRI use... My Story... » newquestions

Posted by garnet71 on April 18, 2009, at 23:51:54

In reply to Effects of long term SSRI use... My Story..., posted by newquestions on April 16, 2009, at 9:10:07

Are you able to force yourself to exercise?

If not, something like Provigil or Segeline may correct some of your symptoms > which would allow you to regain exercise > which would enhance your body's ability to go back to homeostasis.

Ok-no medical theories here, just intuition. I can imagine being in that state that you are spending a lot of time doing nothing. I understand the misery. While on Zoloft, I spent the whole month of December doing aboslutely nothing but laying in my bed day and night-reading about medical problems on the internet. I had zero motivation. However, going off xxRIs and trying alternate drugs has led me to have the ability to exercise again. Although I still suffer from some issues, having a lapse right now from the inability to tolerate Adderall, I am so much better off, and am looking forward to a bright future. :-)

Like I said, what do you have to lose?

 

Re: Effects of long term SSRI use... My Story... » 4ed

Posted by Sigismund on April 19, 2009, at 0:12:26

In reply to Re: Effects of long term SSRI use... My Story..., posted by 4ed on April 18, 2009, at 23:42:02

Now you're talking.

Thank you.

 

Re: Effects of long term SSRI use... My Story...

Posted by SLS on April 19, 2009, at 7:04:05

In reply to Re: Effects of long term SSRI use... My Story... » linkadge, posted by Garnet71 on April 18, 2009, at 20:32:01

> I meant late onset (as opposed to progressive)

Unfortunately, Major Depressive Disorder and Bipolar Disorder ARE progressive diseases in that symptoms worsen over time. There are also what seem to be neurodegenerative processes that occur over the course of the illness, especially if left untreated. The brains of people who are affectively ill demonstrate differences in structure and tissue volume when compared to those of healthy people. It is a scary thing to consider, but the good news is that many of these brain areas recover upon effective treatment, and although there are residual cognitive differences that can be detected in psychometric examinations, very often the differences are not noticed by the patient.


- Scott

 

Re: Effects of long term SSRI use... My Story... » 4ed

Posted by Larry Hoover on April 19, 2009, at 7:28:02

In reply to Re: Effects of long term SSRI use... My Story..., posted by 4ed on April 18, 2009, at 23:42:02

> Let me go out on a limb and tell you all... I was better off taking some MDMA, Ketamine, or Psiylocybin, on occasion. a single dose comibined with accompanying positive set and setting, fixed me for a good while off a single dose.

I'm going to have to agree with your thesis, although I employed LSD. I used to think of it as a mental tonic. The effect lasted a good long while.

Before MDMA became popular as a club drug, it was getting a lot of good scientific press for its use in psychotherapy. Then the "war on drugs" mentality took over.

Lar

 

Re: Effects of long term SSRI use... My Story... » newquestions

Posted by Amelia_in_StPaul on April 19, 2009, at 14:12:38

In reply to Effects of long term SSRI use... My Story..., posted by newquestions on April 16, 2009, at 9:10:07

Oh God, I know what you're talking about. I have said over and over that I wish I never would have been on an SSRI. I recall the 15 minute consultation I received in 1991, after which the doctor whipped out a prescription pad and prescribed Prozac. What a relevation the med was, for about a year. And after, what hell it has been. I too am sensitive to a ton of meds.

I took a break from all meds in April 2007 and ended up in the hospital in March 2008. A year later I am still trying to recover, as, for once in my entire history, the time I was off meds brought on not just a return of major depression, but skyrocketed anxiety and OCD. I cannot describe the hell I was in. It's too painful and it would be too triggering.

I am so sorry. I don't know what else to say to people's stories of hell on meds--I just want you to know that I understand.

 

Re: Effects of long term SSRI use... My Story...

Posted by linkadge on April 19, 2009, at 15:53:13

In reply to Re: Effects of long term SSRI use... My Story..., posted by SLS on April 19, 2009, at 7:04:05

>Unfortunately, Major Depressive Disorder and >Bipolar Disorder ARE progressive diseases in >that symptoms worsen over time.

That is simply not true as a general statement.

 

Re: Effects of long term SSRI use... My Story...

Posted by linkadge on April 19, 2009, at 16:00:32

In reply to Re: Effects of long term SSRI use... My Story... » newquestions, posted by Amelia_in_StPaul on April 19, 2009, at 14:12:38

New research is also showing that SSRI use among adolecents may actually increase depressive behavior in adulthood.

In mice they can acutally induce a model of adult depression by feeding young mice clomipramine or other SSRI drugs. They found that in mice, it leads to a rewiring of conections from the prefrontal cortex to the limbic system.

If the same is true in humans, it may mean we need to rethink the use of SSRI drugs in adolecent depression, especially for extended periods of time.

So when somebody comes on this board and says that they feel that their brain has been permanently altered by medications, why is that so hard for us to digest? From what I have seen, there are a lot of 20 somethings (like myself) who say they were put on SSRI drugs in adolecence and who are only having more problems now. I thinkg its totally possible that the exposure to drugs during that critical period of neural development has lead to some potentially permanat brain changes.

Oh no, my precious prozac would never do anything like that.

Linkadge

 

Re: Effects of long term SSRI use... My Story... » linkadge

Posted by Amelia_in_StPaul on April 19, 2009, at 17:48:42

In reply to Re: Effects of long term SSRI use... My Story..., posted by linkadge on April 19, 2009, at 16:00:32

I was put on in it my early 20s and I know that I am altered (in my late 30s).

 

Re: Effects of long term SSRI use... My Story...

Posted by connor on April 20, 2009, at 1:24:22

In reply to Re: Effects of long term SSRI use... My Story..., posted by linkadge on April 19, 2009, at 16:00:32


I think some people are brain washed, pure and simple. They don't understand how questionable a science antidepressants are. There's no proven chemical imbalance there are just correlations.

When people are given ssri's, some people who are depressed go into remission, this doesen't mean that the problem was solved, it just means it happened to treat the symptoms, I could think of a million drugs to take that would make me feel damn good, ssri's just happen to be the agreed upon method

If this was at all scientific, we wouldn't have multiple classes of antidepressants. When you go on an antidepressant you are taking a shot in the dark period. I was put on these medication in my teens, and I lost so many feelings that make a person human. It's as simple as that. They numb your feelings, for some people this doesen't go away after quitting.

 

Re: Effects of long term SSRI use... My Story...

Posted by SLS on April 20, 2009, at 7:19:11

In reply to Re: Effects of long term SSRI use... My Story..., posted by linkadge on April 19, 2009, at 15:53:13

> >Unfortunately, Major Depressive Disorder and >Bipolar Disorder ARE progressive diseases in >that symptoms worsen over time.
>
> That is simply not true as a general statement.

It took me 5 seconds on Medline to come up with this. There are quite a few more. Why do you even bother anymore?


- Scott


http://www.ncbi.nlm.nih.gov/pubmed/17944926?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


1: Int J Clin Pract. 2007 Dec;61(12):2030-40. Epub 2007 Oct 17.Click here to read Click here to read Links
Neurobiology of depression: an integrated view of key findings.
Maletic V, Robinson M, Oakes T, Iyengar S, Ball SG, Russell J.

School of Medicine, University of South Carolina, Greer, SC 29650, USA. vmaletic@bellsouth.net

AIMS: The objectives of the present review were to summarise the key findings from the clinical literature regarding the neurobiology of major depressive disorder (MDD) and their implications for maximising treatment outcomes. Several neuroanatomical structures in the prefrontal and limbic areas of the brain are involved in affective regulation. In patients with MDD, alterations in the dynamic patterns of activity among these structures have profound implications for the pathogenesis of this illness. DISCUSSION: The present work reviews the evidence for the progressive nature of MDD along with associated changes in neuroanatomical structure and function, especially for the hippocampus. The role of glucocorticoids, inflammatory cytokines and brain-derived growth factors are discussed as mediators of these pathological alterations. From this integrated model, the role of antidepressant therapy in restoring normative processes is examined along with additional treatment guidelines. CONCLUSION: Major depressive disorder is an illness with significant neurobiological consequences involving structural, functional and molecular alterations in several areas of the brain. Antidepressant pharmacotherapy is associated with restoration of the underlying physiology. Clinicians are advised to intervene with MDD using an early, comprehensive treatment approach that has remission as the goal.

PMID: 17944926 [PubMed - indexed for MEDLINE]

 

Re: Effects of long term SSRI use... My Story... » SLS

Posted by linkadge on April 20, 2009, at 8:11:11

In reply to Re: Effects of long term SSRI use... My Story..., posted by SLS on April 20, 2009, at 7:19:11

Do you have any idea what I was saying? I am not saying that some people's mood disorder is not associated with possible hippocamal volume differences, I was only saying that as a general statement this is not true.

For instance, there are many studies such as this one which demonstrate absolutely no difference in hippocampal volume between depressed patients and normal controls.

http://linkinghub.elsevier.com/retrieve/pii/S0006322399002966

Maybe if you read the exact phrasing of my claim you wouldn't become so unnecssarily inflamed.

Linkadge


 

Re: Effects of long term SSRI use... My Story... » linkadge

Posted by SLS on April 20, 2009, at 8:58:31

In reply to Re: Effects of long term SSRI use... My Story... » SLS, posted by linkadge on April 20, 2009, at 8:11:11

> Do you have any idea what I was saying? I am not saying that some people's mood disorder is not associated with possible hippocamal volume differences, I was only saying that as a general statement this is not true.
>
> For instance, there are many studies such as this one which demonstrate absolutely no difference in hippocampal volume between depressed patients and normal controls.
>
> http://linkinghub.elsevier.com/retrieve/pii/S0006322399002966
>
> Maybe if you read the exact phrasing of my claim you wouldn't become so unnecssarily inflamed.
>
> Linkadge


I have been around research clinicians and have conducted my own research long enough to know exactly how pervasive is the opinion that it is indeed worthy of a general statement. I don't expect everyone to agree nor find it a palatable opinion that affective disorders are progressive and perhaps even degenerative if left untreated. However, it is difficult to refute that the severity of early-onset depression increases with age if insufficiently treated.

I guess my statements are merely opinions of opinions. I do apologize that I reacted aggressively to one of your many attempts to discredit me. You have done much worse in the past, so I guess I should cut you some slack.


- Scott

 

Re: Effects of long term SSRI use... My Story...

Posted by linkadge on April 20, 2009, at 10:03:18

In reply to Re: Effects of long term SSRI use... My Story... » linkadge, posted by SLS on April 20, 2009, at 8:58:31

>I guess my statements are merely opinions of >opinions.

I do apologize that I reacted >aggressively to one of your many attempts to >discredit me. You have done much worse in the >past, so I guess I should cut you some slack.

Attemtps?

My arguement is simply that there is no proof that *all* cases of depression are:

a) chronic
b) degenerative
c) associated with significant structural brain
alterations.

If you read the specificity my my statement you will realize it is impossible to refute.

The studies you will find, will point to general *trends* but they are certainly not conclusive about the specific pathology of all depressive disorders.

The study you referenced also makes another sweeping claim that antidepressants "restore" the structural abnormalities in depression. This is unsubstantiated and quite possibly false.

To date there are only a handful of *preliminary* information that show that *some* antidepressants can improve *certain aspects* of brain structure in depression. The only one that comes to the top of my head is a study with paxil on PTSD patients.

Some antidepressants influence certain aspects of hippocampal neurogenesis. This is far from proving that antidepressants do infact reverse the strucal abnormalities associated with certain depressions. I think this is the hope, although there is insufficient evidence at this date to support the notion that this is actually the case.

Linkadge


 

Re: Effects of long term SSRI use... My Story... » Jay_Bravest_Face

Posted by 49er on April 23, 2009, at 19:02:46

In reply to Re: Effects of long term SSRI use... My Story... » linkadge, posted by Jay_Bravest_Face on April 17, 2009, at 1:34:35

Hi Jay,

I am not sure how you can make the statement about drugs causing brain damage not holding up since 2 to 10% of all adverse side effects are ever reported to the FDA.

Also, drug companies have no incentive to do studies on this. To quote Laurie Yorke, the RN who runs the Paxil Progress site that New Questions refers to, the people taking the drugs are the long term studies and no one is collecting the data. I am not sure I am quoting her exactly right but close enough.

Additionally, if doctors routine dismiss complaints by psych patients as part of their illness, how do you expect side effects to ever be reported accurately? I know someone who was involuntarily committed because this person got very frustrated that the psych. wouldn't listen to a complaint about a med side effect. And this is a person who was always compliant about taking some drugs that had horrific side effects.

I don't doubt you when you talk about university students doing well on drugs. They can work great initially. But then there is poopout which happens to most people on psych meds. The brain can only adapt for so long before it starts rebelling.

As far as just dying a few years young, I guess you haven't seen the statistics that patients on psych meds are dying 25 years too early.

And even if you question it, (I don't), Joseph Glenmullen, who is not antimeds, mentions some studies in Prozac Backlash that suggest people start getting neurological damage after long term SSRI use. I don't recall the exact details and I don't claim it is strong research.

But my point is it isn't just an issue of dying a few years young. Actually, my hearing loss from Remeron use and a worsening of LD issues is a perfect example of that.

Anyway, as one who was on 4 meds at one point, I will pass on your advice of a multicocktail. You call it the anti psych meds' sites irresponsible but how is advocating a multi-drug cocktail that has a chance of greatly increasing side effects any more responsible? I know your intentions were good by the way but to be honest, as one who suffered greatly from this multicocktail, I found that very appalling.

Finally, on a different note, I read in another post that you lost your wife and kids in an accident? Sorry, my short term memory is bad.

Anyway, my condolences on your loss. I can't imagine living with that horror.

49er

> > >does worry me that the horror stories are >putting a lot of people off meds who could be >significantly helped.
> >
> > That doesn't worry me one bit. I am still suffering seemingly permanent symptoms very similar to this due to long term SSRI use.
> >
> > I think that it is absolutely critical that people come on and share the full extent of their experiences like this so that potential SSRI users will be able to make informed decisisons about using SSRI's.
> >
> > If all you hear is the rosey storeys that are filtered through drug company websites then there is no way for people to get an acurate picture of the long term safety and efficacy (or lack thereof) of these medications.
> >
> > Linkadge
>
> I think you would consider my story 'rosey' then, as many of those so-called *evil* drugs have helped me, and many others I know. The kind of proper 'cocktail' a good doctor would prescribe has nothing to do with individual drug "fancy stories" put out by drug companies. I honestly think the real reason why many people don't get well is because they don't have a doctor with a depth to use "every arsenal" in combinations that go beyond simplified drug advertising.
>
> I had obtained Abilify, and living in Canada I had to import it. I had amazing success with that med, but unfortunately it's harder to get as it isn't sold here. So, I had to stop a pretty darn good drug.
>
> About 'long term safety'. I think if people where using drugs for 150-200 years, then there may be concern. All of this 'stuff' about people believing they are braindamaged or what, doesn't seem to fold out. I find it very, very irresponsible by those websites that demonize psychiatric medications. I work with a LOT of university students who are also on numerous psychiatric medications. They are completing undergrad and graduate degrees, things that where stopped because of their illness without treatment. I am working on my second undergrad degree right now. There is a beautiful calm that I don't think I even appreciated before treatment, that keeps me focused, able to study hard and write up great research, that I get good marks in. Most of all, I feel content and, yes, happy. Not *all the time*, but quite often/most of time. We don't live much of a long life, anyways, so heck, even if these meds took a year or two off my life, and I could die contented and happy, I wouldn't mind.
>
> I personally have not heard of many people getting *very* well on just one drug. This goes for most mental illness. I knew this actually before I started meds because I had worked on a grant at the Canadian Mental Health Association back in the late 1980's. Polypharmacy, and a fair amount of testing, trial and error, were part of many who got well treatments. Of course, you have to have an openminded doc. I was once going through a REALLY bad, bad time when I first got my new doc. So, he slowly ramped up on a bit of a high dose benzo plus a high dose stimulant. He added two mood stabalizers. That *greatly* got me out of, and through, my tough time. My doc and I still keep that benzo/stim cocktail on our sides, and know it is there if needed again.
>
> Just using one drug seems to be, actually, a not-so-good choice to fight mental illness. (And yes, for all you people on one drug, I don't mean to put you down or anything like that.)
>
> Just IMHO...
> Jay

 

Re: Effects of long term SSRI use... My Story...

Posted by linkadge on April 23, 2009, at 20:20:45

In reply to Re: Effects of long term SSRI use... My Story... » Jay_Bravest_Face, posted by 49er on April 23, 2009, at 19:02:46

Thats an excellent point - we are the long term study. If nobody believes us, then what are we going to learn?

Linkadge

 

Re: Effects of long term SSRI use... My Story...

Posted by sowhysosad on April 23, 2009, at 20:54:44

In reply to Re: Effects of long term SSRI use... My Story... » Jay_Bravest_Face, posted by 49er on April 23, 2009, at 19:02:46

> I am not sure how you can make the statement about drugs causing brain damage not holding up since 2 to 10% of all adverse side effects are ever reported to the FDA.

Probably a stupid question, but how do they quantify side effects that AREN'T reported to the FDA?

> I don't doubt you when you talk about university students doing well on drugs. They can work great initially. But then there is poopout which happens to most people on psych meds. The brain can only adapt for so long before it starts rebelling.

Are there any hard-and-fast statistics relating to "poop-out"? I've taken SSRI's for years at a time and have never experienced anything approaching it.

> As far as just dying a few years young, I guess you haven't seen the statistics that patients on psych meds are dying 25 years too early.

But aren't their a million and one different life-threatening conditions that are associated with depression and anxiety? Heart disease, diabetes, stroke etc.

> And even if you question it, (I don't), Joseph Glenmullen, who is not antimeds, mentions some studies in Prozac Backlash that suggest people start getting neurological damage after long term SSRI use. I don't recall the exact details and I don't claim it is strong research.

There's an interesting, balanced discussion about Glenmullen from some years ago here:

http://www.dr-bob.org/babble/20000411/msgs/29656.html

 

Re: Effects of long term SSRI use... whysosad

Posted by newquestions on April 24, 2009, at 9:40:20

In reply to Re: Effects of long term SSRI use... My Story..., posted by sowhysosad on April 23, 2009, at 20:54:44

What is your drug history?

 

Re: Effects of long term SSRI use... My Story...

Posted by metric on April 24, 2009, at 17:44:13

In reply to Re: Effects of long term SSRI use... My Story..., posted by SLS on April 20, 2009, at 7:19:11

> > >Unfortunately, Major Depressive Disorder and >Bipolar Disorder ARE progressive diseases in >that symptoms worsen over time.
> >
> > That is simply not true as a general statement.
>
> It took me 5 seconds on Medline to come up with this. There are quite a few more. Why do you even bother anymore?
>


I'm sorry, but it's not clear how this abstract is supposed to refute Linkadge's statement.


> - Scott
>
>
> http://www.ncbi.nlm.nih.gov/pubmed/17944926?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
>
>
> 1: Int J Clin Pract. 2007 Dec;61(12):2030-40. Epub 2007 Oct 17.Click here to read Click here to read Links
> Neurobiology of depression: an integrated view of key findings.
> Maletic V, Robinson M, Oakes T, Iyengar S, Ball SG, Russell J.
>
> School of Medicine, University of South Carolina, Greer, SC 29650, USA. vmaletic@bellsouth.net
>
> AIMS: The objectives of the present review were to summarise the key findings from the clinical literature regarding the neurobiology of major depressive disorder (MDD) and their implications for maximising treatment outcomes. Several neuroanatomical structures in the prefrontal and limbic areas of the brain are involved in affective regulation. In patients with MDD, alterations in the dynamic patterns of activity among these structures have profound implications for the pathogenesis of this illness. DISCUSSION: The present work reviews the evidence for the progressive nature of MDD along with associated changes in neuroanatomical structure and function, especially for the hippocampus. The role of glucocorticoids, inflammatory cytokines and brain-derived growth factors are discussed as mediators of these pathological alterations. From this integrated model, the role of antidepressant therapy in restoring normative processes is examined along with additional treatment guidelines. CONCLUSION: Major depressive disorder is an illness with significant neurobiological consequences involving structural, functional and molecular alterations in several areas of the brain. Antidepressant pharmacotherapy is associated with restoration of the underlying physiology. Clinicians are advised to intervene with MDD using an early, comprehensive treatment approach that has remission as the goal.
>
> PMID: 17944926 [PubMed - indexed for MEDLINE]
>
>

 

Re: Effects of long term SSRI use... My Story... » metric

Posted by SLS on April 24, 2009, at 19:37:49

In reply to Re: Effects of long term SSRI use... My Story..., posted by metric on April 24, 2009, at 17:44:13

> I'm sorry, but it's not clear how this abstract is supposed to refute Linkadge's statement.

Which one?

What do you find not clear?

As for scrutinizing words, my original post was specific name Major Depressive Disorder (MDD) as the illness I was speaking of, and not to the generic word "depression".

Do you refute the progressive nature of MDD?


- Scott


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