Psycho-Babble Medication Thread 889950

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Antidepressants induce cellular insulin resistance

Posted by Alexanderfromdenmark on April 11, 2009, at 11:10:15

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WNB-4P2YWPW-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3b353626b2f8d8ce523b781df343e46c

"Abstract
Certain selective serotonin reuptake inhibitors (SSRIs) induce the clinical and biochemical manifestations of a metabolic syndrome by as yet unknown mechanism. Here we demonstrate that incubation (1 h) of rat hepatoma Fao cells with the SSRIs paroxetine and sertraline, but not with the atypical antipsychotic drug olanzapine, inhibited the insulin-stimulated Tyr phosphorylation of the insulin receptor substrate-1 (IRS-1) with half-maximal effects at 10 μM. This inhibition correlated with a rapid phosphorylation and activation of a number of Ser/Thr IRS-1 kinases including JNK, S6K1, ERK and p38 MAPK, but not PKB (Akt). JNK appears as a key player activated by SSRIs because specific JNK inhibitors partially eliminated the effects of these drugs. The SSRIs induced the phosphorylation of IRS-1 on S307 and S408, which inhibits IRS-1 function and insulin signaling. These results implicate selected SSRIs as inhibitors of insulin signaling and as potential inducers of cellular insulin resistance."

Can someone tell me the significance of this?

 

Re: Antidepressants induce cellular insulin resistance

Posted by SLS on April 11, 2009, at 12:42:47

In reply to Antidepressants induce cellular insulin resistance, posted by Alexanderfromdenmark on April 11, 2009, at 11:10:15

The body's cell receptors that normally "see" insulin have become blinded. Glucose is no longer being absorbed for storage in muscle cells. You are essentially creating a condition by which blood sugar remains elevated. It is often considered a prelude to diabetes.


- Scott

 

Re: Antidepressants induce cellular insulin resistance

Posted by SLS on April 11, 2009, at 12:52:40

In reply to Re: Antidepressants induce cellular insulin resistance, posted by SLS on April 11, 2009, at 12:42:47

I forgot to mention that insulin resistance is also part of the "metabolic syndrome" that demonstrates a higher rate of heart attack and death.


- Scott

 

Re: Antidepressants induce cellular insulin resistance » SLS

Posted by Phillipa on April 11, 2009, at 12:58:49

In reply to Re: Antidepressants induce cellular insulin resistance, posted by SLS on April 11, 2009, at 12:52:40

Doen't that include thyroid also? A doc a long time ago also said that low blood sugar was a prelude to diabetes also right or wrong as times change and medical knowledge. Love Phillipa

 

Re: Antidepressants induce cellular insulin resistance

Posted by Alexanderfromdenmark on April 11, 2009, at 13:25:46

In reply to Re: Antidepressants induce cellular insulin resistance, posted by SLS on April 11, 2009, at 12:42:47

> The body's cell receptors that normally "see" insulin have become blinded. Glucose is no longer being absorbed for storage in muscle cells. You are essentially creating a condition by which blood sugar remains elevated. It is often considered a prelude to diabetes.
>
>
> - Scott

Well that aint too good now is it? Get's you thinking.

 

Re: Antidepressants induce cellular insulin resistance » Alexanderfromdenmark

Posted by Larry Hoover on April 11, 2009, at 16:07:27

In reply to Re: Antidepressants induce cellular insulin resistance, posted by Alexanderfromdenmark on April 11, 2009, at 13:25:46

I'm a little bit disinclined towards making predictions in humans when a study was based on rat liver cancer cells. However, the effect does appear to be real. Citalopram (and presumably escitalopram) would appear to not be associated with this effect.

As the rat study came after the following one, I presume they were looking for some sort of a mechanism.

Lar

J Clin Psychiatry. 2006 Dec;67(12):1974-82.
Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health Study.
Raeder MB, Bjelland I, Emil Vollset S, Steen VM.
Einar Martens' Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Helse Bergen HF, Norway. maria.rader@uib.no

OBJECTIVE: This study aimed to examine whether subjects taking selective serotonin reuptake inhibitors (SSRIs) are more likely to have elements of the metabolic syndrome compared with those taking no psychotropic drugs. For comparison, we also studied subjects taking antipsychotic drugs. METHOD: We used data from The Hordaland Health Study '97-'99, a general community cross-sectional health survey including 25,315 subjects aged 40 to 49 and 70 to 74 years. For the groups studied, we estimated prevalence and odds ratios (ORs) for obesity, hypercholesterolemia, low high-density lipoprotein cholesterol, hyper-triglyceridemia, and diabetes. RESULTS: We observed an association between use of SSRIs as a group (N = 461) and abdominal obesity (OR = 1.40, 95% CI = 1.08 to 1.81) and hypercholesterolemia (OR = 1.36, 95% CI = 1.07 to 1.73) after adjusting for multiple possible confounders. There was also a trend toward an association between SSRI use and diabetes. In a subgroup analysis of subjects taking SSRIs, the use of paroxetine (N = 187) was markedly associated with both general and abdominal obesity but not with hypercholesterolemia. In contrast, the use of citalopram (N = 142) was not associated with any of the metabolic outcome variables, while the use of any other SSRI (sertraline, fluoxetine, or fluvoxamine) (N = 131) as a mixed subgroup was associated with both abdominal obesity and hypercholesterolemia. We also replicated the previously reported associations between use of antipsychotics and obesity and metabolic disturbances. CONCLUSION: We have shown that use of at least some SSRIs is associated with clinical and biochemical elements of the metabolic syndrome. Our data indicate differences in the metabolic side effect profile among various SSRI drugs, although treatment bias might have influenced these results. We suggest that patients taking SSRIs be carefully monitored for obesity and dyslipidemia.

 

Re: Antidepressants induce cellular insulin resistance

Posted by linkadge on April 12, 2009, at 6:42:58

In reply to Antidepressants induce cellular insulin resistance, posted by Alexanderfromdenmark on April 11, 2009, at 11:10:15

It means SSRI's are not safe.

Linkadge

 

Re: Antidepressants induce cellular insulin resistance

Posted by linkadge on April 12, 2009, at 6:50:15

In reply to Re: Antidepressants induce cellular insulin resistance, posted by linkadge on April 12, 2009, at 6:42:58

The above study doesn't really exonerate citalopram. Serotonin signaling is intricately involved in the body's release and utilization of insulin. The SSRI's are neuroendocrine disruptors and potentially diabetoganic.

Its about time a drug company releases trans-resveratrol as an antidepressant. It shows potent antidepressant effects, and mind help stave off metabolic and other age associated diseases.

 

Re: Antidepressants induce cellular insulin resistance

Posted by Zana on April 12, 2009, at 15:09:56

In reply to Re: Antidepressants induce cellular insulin resistance, posted by linkadge on April 12, 2009, at 6:50:15

I thought reservatol was an antioxidant found in red grape skins. What psychiatric use does it have?
Do you have to gain weight to be on the road to diabeties? or metabolic syndrome?

Zanz

 

Re: Antidepressants induce cellular insulin resistance

Posted by linkadge on April 12, 2009, at 16:32:23

In reply to Re: Antidepressants induce cellular insulin resistance, posted by Zana on April 12, 2009, at 15:09:56

T-resveratrol also has monoamine reuptake inhibiting properties as well as MAO inhibiting properties. It has potent activity in animal models of depression.

You don't have to gain wait to get diabetes.


Linkadge

 

Re: Antidepressants induce cellular insulin resist

Posted by NewQuestions on April 14, 2009, at 9:11:20

In reply to Re: Antidepressants induce cellular insulin resistance, posted by linkadge on April 12, 2009, at 16:32:23

My triglycerides are way too high. Could this be related?

 

Re: Antidepressants induce cellular insulin resist

Posted by Alexanderfromdenmark on April 14, 2009, at 14:08:57

In reply to Re: Antidepressants induce cellular insulin resist, posted by NewQuestions on April 14, 2009, at 9:11:20

> My triglycerides are way too high. Could this be related?

We can't really know. You'd have to be tested for pre-diabetes to confirm that I suppose.

Newquestions, you've had a lot a post-ssri problems. How's all that working out? Doing better?

 

Re: Antidepressants induce cellular insulin resist

Posted by NewQuestions on April 16, 2009, at 8:29:29

In reply to Re: Antidepressants induce cellular insulin resist, posted by Alexanderfromdenmark on April 14, 2009, at 14:08:57

Right now, I am 5 months off of everything. I am extremely sensitive to all antidepressants and benzos, amino acids, and certain vitamins, which I attribute to long term SSRI use. My most distressing problem now is cognitive decline. I can't think anymore, I have no mental traction. I have a vacant feeling. My only hope is that it will come back with time.

 

Re: Antidepressants induce cellular insulin resist » NewQuestions

Posted by Phillipa on April 16, 2009, at 19:42:40

In reply to Re: Antidepressants induce cellular insulin resist, posted by NewQuestions on April 16, 2009, at 8:29:29

Were your doses really high? As have been on meds for many years. I truly hope it's not from SSRI's. Love Phillipa

 

Re: Antidepressants induce cellular insulin resist

Posted by sowhysosad on April 16, 2009, at 20:07:59

In reply to Re: Antidepressants induce cellular insulin resistance, posted by SLS on April 11, 2009, at 12:42:47

Oddly, taking fluoxetine tends to LOWER blood sugar in type 2 diabetics and makes them more prone to hypoglycaemia.

Not sure how that fits in with this research.

 

Re: Antidepressants induce cellular insulin resist

Posted by Alexanderfromdenmark on April 26, 2009, at 17:38:56

In reply to Re: Antidepressants induce cellular insulin resist, posted by sowhysosad on April 16, 2009, at 20:07:59

> Oddly, taking fluoxetine tends to LOWER blood sugar in type 2 diabetics and makes them more prone to hypoglycaemia.
>
> Not sure how that fits in with this research.

About that
http://www.medscape.com/viewarticle/590844

 

Re: Antidepressants induce cellular insulin resist

Posted by zzzz7 on May 1, 2009, at 22:16:17

In reply to Re: Antidepressants induce cellular insulin resist, posted by NewQuestions on April 14, 2009, at 9:11:20

Interestingly, in addition to not being able to take more than .1mg of an SSRI without getting depressed (and before I was on things like 110mg Prozac), I've developed bad reactive hypoglycemia. I'd not be surprised if the two were connected somehow.


(To say a bit more about my condition: If I take nothing, serotonin levels rise during the day and make me depressed. I can get some temporary relief with a dopamine agonist, but if I take too much (e.g. more than 50 mg amantadine), I get depressed. So I'm on a see saw between too much serotonin and too much dopamine.)



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