![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by Michael Bell on March 25, 2009, at 16:38:19
Are there any legal substances that act purely as dopamine reuptake inhibitors, meaning they have no effect on norepinephrine or serotonin reuptake?
Posted by garnet71 on March 25, 2009, at 16:57:27
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
Here's a list you could look into:
Dopaminergics
Dopaminergics are substances that affect the neurotransmitter dopamine or the components of the nervous system that use dopamine. Dopamine is produced in the synthesis of all catecholamine neurotransmitters, and is the rate limiting step for this synthesis. Dopaminergic nootropics include dopamine precursors and cofactors, agonists, MAOIs, and dopamine reuptake inhibitors:
L-dopa - Prescription drug. Precursor to the neurotransmitter dopamine. Parkinson disease treatment.
Phenylalanine (requires Vitamin B6 and Vitamin C) - Essential amino acid. Precursor to dopamine, stimulant, sleep reducer.
Theanine - Found in tea. Increases serotonin, GABA and dopamine levels in the brain. Increases alpha-wave based alert relaxation.
Tyrosine (requires Vitamin B6 and Vitamin C) - Amino acid. Precursor to dopamine, anti-depressant, sleep reducer.
Vitamin C- improves cardiovascular elasticity and integrity, membrane stabilizer and major anti-oxidant (protects brain cells and prevents brain cell death), cofactor in the production of the neurotransmitters dopamine and serotonin.
Vitamin B6 - co-factor used by the body to produce dopamine.
Yohimbine - boosts dopamine levels through an unknown mechanism. Sometimes used as an aphrodisiac. Poses health risks: it is a neuro-paralytic which slows down breathing and induces acidosis, some symptoms of which are malaise, nausea, and vomiting. Contraindicated for users of megadoses of acidic vitamins or nutrients.[citation needed]
MAOIs such as Selegiline which inhibits MAO-B (an enzyme that breaks down dopamine) thus raising dopamine by partially inhibiting its breakdown. (In large doses it also inhibits MAO-A)
Tolcapone - Inhibits COMT (an enzyme that breaks down the neurotransmitters dopamine, epinephrine, and norepinephrine) and increases performance in tasks depending on working memory in individuals with the val/val and val/met genotype of the val158Met polymorphism of the catechol-O-methyltransferase gene, while decreasing it in presence of the met/met version. Tolcapone presents the risk of deadly side effects.
Bupropion atypical antidepressant. Dopamine reuptake inhibitor.
Dopamine agonists such as pergolide
http://en.wikipedia.org/wiki/Dopaminergic
Posted by mav27 on March 25, 2009, at 20:45:04
In reply to Re: are there any pure dopamine reuptake inhibitors? » Michael Bell, posted by garnet71 on March 25, 2009, at 16:57:27
But basically no, nothing that isn't just used in studies and called drug jdh39922 or however they label them :)
Posted by SLS on March 25, 2009, at 21:19:20
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
> Are there any legal substances that act purely as dopamine reuptake inhibitors, meaning they have no effect on norepinephrine or serotonin reuptake?
The only one that I am aware of is amineptine (Survector).
Amineptine was withdrawn from worldwide markets because it had gained a reputation of being addictive and used as an athletic performance enhancer. The Olympic committee made amineptine a banned substance. The drug was really not that addictive. For some people, it is the only drug that ever worked. Many actually combined amineptine with a low dosage of amisulpride for the increase in the synthesis and release of dopamine that this drug elicits.
- Scott
Posted by TriedEveryDrug on March 25, 2009, at 23:20:17
In reply to Re: are there any pure dopamine reuptake inhibitors? » Michael Bell, posted by SLS on March 25, 2009, at 21:19:20
Pity this med got yanked. I would have loved to have tried it for ADD.
Posted by metric on March 26, 2009, at 13:30:57
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
> Are there any legal substances that act purely as dopamine reuptake inhibitors, meaning they have no effect on norepinephrine or serotonin reuptake?
No.
Posted by Sigismund on March 26, 2009, at 19:53:05
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
What about a low dose Ritalin Dexedrine combo?
Posted by Neal on March 26, 2009, at 21:54:20
In reply to Re: are there any pure dopamine reuptake inhibitor » Michael Bell, posted by metric on March 26, 2009, at 13:30:57
Adderal?
Posted by mav27 on March 26, 2009, at 22:20:47
In reply to Re: are there any pure dopamine reuptake inhibitors?, posted by Sigismund on March 26, 2009, at 19:53:05
> What about a low dose Ritalin Dexedrine combo?
Stimulants cause a release in dopamine and noradrenaline don't they? So they wouldn't be dopamine reuptake inhibitors. And he wants something that doesn't effect noradrenaline anyway which is sure the stimulants do even if you forget about the pricess being reuptake inhibition ect
Posted by myco on March 26, 2009, at 22:54:53
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
What about using something to increase L-dopa or dopamine specifically...easy to obtain substance for this in the usa is dopa bean (Mucuna pruriens or "velvet bean" as it's called)...or hell even just straight up L-tyrosine or phenylalanine. These will increase L-dopa then dopamine then you could add an inhibitor to prevent/slow NE synthesis from dopamine. I'm not sure what to use yet, I havent thought about this approach. I know natural decarboxylase inhibitors like EGCG (needs cofactor vitamin B6) in green tea extract will inhibit the formation of dopamine from L-dopa. So there must be an inhibitor to block the pathway inbetween dopamine and norepinephrine. Research a lil?
> Are there any legal substances that act purely as dopamine reuptake inhibitors, meaning they have no effect on norepinephrine or serotonin reuptake?
Posted by desolationrower on March 27, 2009, at 3:22:55
In reply to Re: are there any pure dopamine reuptake inhibitors? » Michael Bell, posted by myco on March 26, 2009, at 22:54:53
> What about using something to increase L-dopa or dopamine specifically...easy to obtain substance for this in the usa is dopa bean (Mucuna pruriens or "velvet bean" as it's called)...or hell even just straight up L-tyrosine or phenylalanine. These will increase L-dopa then dopamine then you could add an inhibitor to prevent/slow NE synthesis from dopamine. I'm not sure what to use yet, I havent thought about this approach. I know natural decarboxylase inhibitors like EGCG (needs cofactor vitamin B6) in green tea extract will inhibit the formation of dopamine from L-dopa. So there must be an inhibitor to block the pathway inbetween dopamine and norepinephrine. Research a lil?
>
>
> > Are there any legal substances that act purely as dopamine reuptake inhibitors, meaning they have no effect on norepinephrine or serotonin reuptake?
>
>dopamine beta-hydroxylase
but dopamine agonists aren't the same as substances which block teh DAT.
-d/r
Posted by myco on March 27, 2009, at 11:32:33
In reply to Re: are there any pure dopamine reuptake inhibitors?, posted by desolationrower on March 27, 2009, at 3:22:55
Are these available in natural forms? I know nothing of these...time to look at pubmed.
In the end doesn't an agonist produce the same results as an inhibitor for a step in the pathway?...or do you get a "serge" after the inhibitor wears off?
myco
-----------------
> dopamine beta-hydroxylase
>
> but dopamine agonists aren't the same as substances which block teh DAT.
>
> -d/r
Posted by Michael Bell on March 27, 2009, at 16:05:50
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
Thanks for all the replies. As some of you pointed out, there do not seem to be any substances that specifically affect reuptake of dopamine, as the ones that are out there tend to affect reuptake and release of norepinephrine as well (i.e. stimulants, wellbutrin). My personal feeling is that a substance, or a combo of substances, that affect only serotonin and dopamine reuptake, will be quite effective for social phobia. Unfortunately, all we have are SSRIs, SNRIs, and triple reuptake inhibitors, but none that affect just dopamine or just dopamine and serotonin. Guess I'll have to check out various herbs and supplements to see what is out there.
Posted by desolationrower on March 28, 2009, at 20:13:22
In reply to Re: are there any pure dopamine reuptake inhibitors? » desolationrower, posted by myco on March 27, 2009, at 11:32:33
> Are these available in natural forms? I know nothing of these...time to look at pubmed.
>
> In the end doesn't an agonist produce the same results as an inhibitor for a step in the pathway?...or do you get a "serge" after the inhibitor wears off?
>
> myco
>
> -----------------
>
>
> > dopamine beta-hydroxylase
> >
> > but dopamine agonists aren't the same as substances which block teh DAT.
> >
> > -d/r
>
>agonist will have some distribution in the brain. an inhibitor will have a different one. and the inhibitors effects will be much stronger where the enzyme is more prevalent. mao and comt don't have the same distribution, either in brain structures, or extra/intra cellularly, neuronal/glial, etc.
mentioned enzyme is the one that takes DA->NA. i i think disulfiram is an inhibitor.
-d/r
Posted by psychobot5000 on July 6, 2012, at 1:01:36
In reply to are there any pure dopamine reuptake inhibitors?, posted by Michael Bell on March 25, 2009, at 16:38:19
> Are there any legal substances that act purely as dopamine reuptake inhibitors, meaning they have no effect on norepinephrine or serotonin reuptake?
Saw this and thought I'd answer the original question posed in this old thread: though it's difficult, chemically, to block the DAT without blocking the NET as well, there is one substance I'm aware of which is a relatively pure dopamine reuptake inhibitor: flowering quince extract, also known as mu gua, or sweet nakai.
A 'powdered concentrate' thereof can be purchased from KT Botanicals.
At high doses, the substance has small effects on the noradrenaline system. But mostly it's clean.
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.