Psycho-Babble Medication Thread 838229

Shown: posts 1 to 10 of 10. This is the beginning of the thread.

 

Do all TCAs feel like Desipramine?

Posted by bleep on July 5, 2008, at 15:40:34

I tried Desipramine for 3 days and my heart was beating so fast it made my chest hurt and my bp was so low I had to lie down...are they all like this? Since I can't take SSRIs my pdoc said it's TCAs. Just wondered if they all do that. If so, I guess MAOIs are the next line right?

 

Re: Do all TCAs feel like Desipramine?

Posted by fachad on July 6, 2008, at 11:46:51

In reply to Do all TCAs feel like Desipramine?, posted by bleep on July 5, 2008, at 15:40:34

No, desipramine is unique. It is a VERY potent noradrenergic drug, and has the FEWEST side effects of any of the TCAs.

So it is likely to make you fell racey, but other TCAs are more likely to give you dry mouth, drowsiness, etc.

 

Re: Do all TCAs feel like Desipramine?

Posted by Phillipa on July 6, 2008, at 12:37:13

In reply to Re: Do all TCAs feel like Desipramine?, posted by fachad on July 6, 2008, at 11:46:51

Pamelor made me very sleepy and no raciness. Maybe try that? Phillipa

 

while the 'cleanest' TCA, it has serious isses

Posted by iforgotmypassword on July 6, 2008, at 14:59:26

In reply to Re: Do all TCAs feel like Desipramine?, posted by Phillipa on July 6, 2008, at 12:37:13

it is the most cardiotoxic, and it appears to be the most, or one of the most genotoxic. more information on it's carcinogenicity and mutagenicity may be appearing. a 2002 study on the bone marrow of mice apparently indicated mutagenicity, and this is an mammalian animal model (compared to the fruit fly study, which was still possibly very notable tho, mind you) so i gather this may be a solid reason why the researchers urged further investigation of the issue.

whether it can f*** up human sperm or egg cells, i am not sure, but i am personally pretty scared by the idea. (i may elaborate on why, as it something that really preoccupies me.)

it is probably the TCA most associated with sudden death (as this, i am pretty sure, is a matter relating to cardiotoxity) and it is the most toxic TCA in overdose.

i want to post more on my experience with desipramine soon, as it was quite a notable therapeutic in my case. i just have a lot of trouble with concentration.

 

Re: while the 'cleanest' TCA, it has serious isses iforgotmypassword

Posted by bleep on July 6, 2008, at 16:35:06

In reply to while the 'cleanest' TCA, it has serious isses, posted by iforgotmypassword on July 6, 2008, at 14:59:26

Is it still toxic after you stop taking it? What if you only took it for 3 days?! I seriously felt like I was having a heart attack...my pdoc thought I was full of it and told me to discontinue (I was taking 25 mg 2 x daily) for 2 days and restart @ 25 mg once a day but I said No I'm not taking that stuff anymore...now I'm glad I decided not to.

 

Re: Do all TCAs feel like Desipramine? fachad

Posted by SLS on July 6, 2008, at 16:47:02

In reply to Re: Do all TCAs feel like Desipramine?, posted by fachad on July 6, 2008, at 11:46:51

> No, desipramine is unique. It is a VERY potent noradrenergic drug, and has the FEWEST side effects of any of the TCAs.
>
> So it is likely to make you fell racey, but other TCAs are more likely to give you dry mouth, drowsiness, etc.

How would you compare desipramine to nortriptyline?


- Scott

 

Above post meant for (nm) iforgotmypassword

Posted by SLS on July 6, 2008, at 16:48:18

In reply to while the 'cleanest' TCA, it has serious isses, posted by iforgotmypassword on July 6, 2008, at 14:59:26

 

Re: Above post meant for

Posted by linkadge on July 6, 2008, at 18:19:27

In reply to Above post meant for (nm) iforgotmypassword, posted by SLS on July 6, 2008, at 16:48:18

Some of the TCA's are clearly genotoxic. I don't think nortyptaline was one of them, but desipramine, doxapin, trimipramine were among those identified as being genotoxic.

Linkadge

 

Desipramine vs. Nortriptyline

Posted by fachad on July 6, 2008, at 22:57:27

In reply to Re: Do all TCAs feel like Desipramine? fachad, posted by SLS on July 6, 2008, at 16:47:02

Desipramine is much more potent - in theory - as a noradregenic reuptake blocker.

However, for all the other (i.e. non-target) receptors nortriptyline is much more potent.

So you can expect more sedation, weight gain, dry mouth, constipation, dizziness on standing up, etc from nortriptyline.

Nortriptyline is a much more "dirty" drug, although it is much cleaner than the parent TCA drugs (amitriptyline/Elavil is the parent for nortriptyline and imipramine/Tofranl is the parent for desipramine).

> > No, desipramine is unique. It is a VERY potent noradrenergic drug, and has the FEWEST side effects of any of the TCAs.
> >
> > So it is likely to make you fell racey, but other TCAs are more likely to give you dry mouth, drowsiness, etc.
>
> How would you compare desipramine to nortriptyline?
>
>
> - Scott

 

Re: Desipramine vs. Nortriptyline fachad

Posted by SLS on July 7, 2008, at 4:27:02

In reply to Desipramine vs. Nortriptyline, posted by fachad on July 6, 2008, at 22:57:27

Thanks for reminding me that receptors also come into play. I would have not considered it otherwise. I prefer the "feel" of nortriptyline over desipramine. It feels like it promotes a lessening of anhedonia superior to that of desipramine. I currently take 150mg of nortriptyline along with other drugs. I found nortriptyline to be soporific during the first 1-2 weeks, after which it displayed no such tendency. I would say that nortriptyline feels cleaner than desipramine because desipramine evokes much greater sympathetic tone. Desipramine causes my heart to race with palpitations. In addition, my mouth was dryer and a few other side effects that appear similar to anticholinergia because of the imbalance in sympathetic / parasympathetic activation.

> Desipramine is much more potent - in theory - as a noradregenic reuptake blocker.
>
> However, for all the other (i.e. non-target) receptors nortriptyline is much more potent.
>
> So you can expect more sedation, weight gain, dry mouth, constipation, dizziness on standing up, etc from nortriptyline.
>
> Nortriptyline is a much more "dirty" drug, although it is much cleaner than the parent TCA drugs (amitriptyline/Elavil is the parent for nortriptyline and imipramine/Tofranl is the parent for desipramine).
>
> > > No, desipramine is unique. It is a VERY potent noradrenergic drug, and has the FEWEST side effects of any of the TCAs.
> > >
> > > So it is likely to make you fell racey, but other TCAs are more likely to give you dry mouth, drowsiness, etc.
> >
> > How would you compare desipramine to nortriptyline?
> >
> >
> > - Scott
>
>


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