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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by maoi_wowee on July 3, 2008, at 20:18:20
I had originally planned to switch from Nardil back to Parnate, but am now thinking that giving Marplan a shot would make sense.
Can anyone provide any tell me what a minimal washout period should be between Nardil and Marplan. I know that the common notion is 7-14 days, but I've heard that the two meds are somewhat similar so I'm wondering if this is an overly cautious washout period.
Thanks!
Posted by Phoenix1 on July 3, 2008, at 20:40:29
In reply to Nardil to Marplan washout period, posted by maoi_wowee on July 3, 2008, at 20:18:20
I have to agree with what blueboy said in your previous thread. It's playing with fire. My MAOI switching experience led to a very nasty neurologic condition that has left me with vision loss, and confusion. Play it safe, as these meds are very powerful. Wait the 14 days.
Phoenix
Posted by SLS on July 4, 2008, at 4:38:53
In reply to Re: Nardil to Marplan washout period » maoi_wowee, posted by Phoenix1 on July 3, 2008, at 20:40:29
> I have to agree with what blueboy said in your previous thread. It's playing with fire. My MAOI switching experience led to a very nasty neurologic condition that has left me with vision loss, and confusion. Play it safe, as these meds are very powerful. Wait the 14 days.
This is especially true of Nardil. It takes longer to reestablish MAO activity after discontinuing Nardil than it does for Parnate.
Thanks, Phoenix1, for sharing your horrific story.
- Scott- Scott
Posted by undopaminergic on July 4, 2008, at 8:40:04
In reply to Re: Nardil to Marplan washout period, posted by SLS on July 4, 2008, at 4:38:53
>
> This is especially true of Nardil. It takes longer to reestablish MAO activity after discontinuing Nardil than it does for Parnate.
>Why would you want to allow MAO activity to return?
Cross-tapering from one MAOI onto another would seem the most sensible and efficient approach, but failing that, a more cautious option would be to wait a few half lives of the discontinued MAOI before starting titration of the new MAOI.
What is the half-life of phenelzine (Nardil)?
Posted by SLS on July 4, 2008, at 8:52:13
In reply to Re: Nardil to Marplan washout period, posted by undopaminergic on July 4, 2008, at 8:40:04
Your reasoning is impeccable, but...
These drugs do things other than inhibit MAO. Co-administration of the two drugs can, and has, been associated with strokes. NYU doctors have witnessed this and would not consent to my doing such a thing.
- Scott
Posted by undopaminergic on July 4, 2008, at 14:28:06
In reply to Re: Nardil to Marplan washout period » undopaminergic, posted by SLS on July 4, 2008, at 8:52:13
> Your reasoning is impeccable, but...
>
> These drugs do things other than inhibit MAO. Co-administration of the two drugs can, and has, been associated with strokes. NYU doctors have witnessed this and would not consent to my doing such a thing.
>It would be desirable to clarify which combinations are dangerous, at what doses, and why. There is currently too much rumour, fear and magical thinking regarding this and other MAOI-related matters.
Posted by SLS on July 4, 2008, at 15:57:16
In reply to Re: Nardil to Marplan washout period, posted by undopaminergic on July 4, 2008, at 14:28:06
> > Your reasoning is impeccable, but...
> >
> > These drugs do things other than inhibit MAO. Co-administration of the two drugs can, and has, been associated with strokes. NYU doctors have witnessed this and would not consent to my doing such a thing.
> >
>
> It would be desirable to clarify which combinations are dangerous,
For the sake of clarification in vivo for humans, would you be willing to be the first guinea pig to die for an answer?
- Scott
Posted by undopaminergic on July 6, 2008, at 2:20:45
In reply to Re: Nardil to Marplan washout period » undopaminergic, posted by SLS on July 4, 2008, at 15:57:16
Well, I suppose I could venture to try some selegiline with rasagiline, but I'm not interested at this time in taking enough of them to cause death.
This is the end of the thread.
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