Psycho-Babble Medication Thread 805014

Shown: posts 1 to 10 of 10. This is the beginning of the thread.

 

T3 + Remeron

Posted by tensor on January 8, 2008, at 5:32:45

I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?

/Mattias

 

Re: T3 + Remeron » tensor

Posted by SLS on January 8, 2008, at 5:54:35

In reply to T3 + Remeron, posted by tensor on January 8, 2008, at 5:32:45

> I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?
>
> /Mattias

I don't know, but your idea has merit as being possibly effective. T3 produces an increase in the sensitivity of postsynaptic NE receptors. Remeron produces an increase in the release of NE. Maybe they are to be synergistic.

Personally, T3 wrecked me. It exacerbated my depression severely. I found T4 much more helpful. Perhaps this is a bipolar thing.


- Scott

 

Re: T3 + Remeron » SLS

Posted by tensor on January 8, 2008, at 6:10:28

In reply to Re: T3 + Remeron » tensor, posted by SLS on January 8, 2008, at 5:54:35

>T3 produces an increase in the sensitivity of postsynaptic NE receptors. Remeron produces an increase in the release of NE. Maybe they are to be synergistic.

I'm thinking in the same way, despite the lack of studies it might be helpful. It shouldn't necessarily need to be an NRI.

>Personally, T3 wrecked me. It exacerbated my depression severely. I found T4 much more helpful. Perhaps this is a bipolar thing.

Sorry to hear that. I'm pretty certain I'm strictly unipolar, haven't seen any signs that would suggest otherwise. This T3/T4 thing is pretty tricky. If your thyroid is functioning well and turning T4 into T3, would it really matter which one you took?
The thing is, I can get T4 here with a regular prescription but with T3 my pdoc needs to apply for a license to prescribe it, I don't know how much trouble that is.
Which dose of T4 do you found to be most helpful?

/Mattias

 

Re: T3 + Remeron » tensor

Posted by SLS on January 8, 2008, at 6:52:35

In reply to Re: T3 + Remeron » SLS, posted by tensor on January 8, 2008, at 6:10:28

> >T3 produces an increase in the sensitivity of postsynaptic NE receptors. Remeron produces an increase in the release of NE. Maybe they are to be synergistic.
>
> I'm thinking in the same way, despite the lack of studies it might be helpful. It shouldn't necessarily need to be an NRI.

Remeron is an antagonist of the presynaptic NE alpha2 autoreceptor, not a reuptake inhibitor. It thus enhances both the synthesis and release of NE. It is an interesting combination.

> This T3/T4 thing is pretty tricky. If your thyroid is functioning well and turning T4 into T3, would it really matter which one you took?

Yes. I am an example of this.

The problem is, I don't know which one to suggest to you. Perhaps the production of T3 is better balanced if T4 is used as the augmenter. Because the stuff I've read about T4 involves bipolar disorder - particularly rapid cycling BD - I would probably try T3 first as it is the drug most closely studied. However, just because T3 was initially chosen to study, does not assure its advantage over T4.

> Which dose of T4 do you found to be most helpful?

Hell if I can remember. Sorry I couldn't be of more help.


- Scott

 

Re: T3 + Remeron + ranitidine

Posted by Maria3667 on January 8, 2008, at 14:28:21

In reply to T3 + Remeron, posted by tensor on January 8, 2008, at 5:32:45

Hi Mattias,

Do you want to adjunct with T3 because of weight gain? In my personal experience this wasn't effective...

However, adding ranitidine (med against acid reflux) did actually stop the weight gain dead in it's tracks. Between psychiatrists this is a well known secret...

Maria

> I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?
>
> /Mattias

 

Re: T3 + Remeron + ranitidine » Maria3667

Posted by Phoenix1 on January 8, 2008, at 14:51:02

In reply to Re: T3 + Remeron + ranitidine, posted by Maria3667 on January 8, 2008, at 14:28:21

> Hi Mattias,
>
> Do you want to adjunct with T3 because of weight gain? In my personal experience this wasn't effective...
>
> However, adding ranitidine (med against acid reflux) did actually stop the weight gain dead in it's tracks. Between psychiatrists this is a well known secret...
>
> Maria
>
> > I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?
> >
> > /Mattias
>
>

Hi Maria,

How much Ranitidine is required? Is there any literature on this? Do you think it would stop MAOI weight gain or is this a different mechanism?

Thanks,

Phoenix1

 

Re: T3 + Remeron + ranitidine » Maria3667

Posted by tensor on January 8, 2008, at 16:18:37

In reply to Re: T3 + Remeron + ranitidine, posted by Maria3667 on January 8, 2008, at 14:28:21

> Do you want to adjunct with T3 because of weight gain? In my personal experience this wasn't effective...

No, it's for boosting the antidepressant effect of my current AD's. That's the thought, i.e. I have been using H2 blockers like ranitidine and famotidine(Pepcid, which I prefer) for acid reflux which I get sometimes from hypnotics, but not long term. I have never thought of ranitidine as a way of avoiding weight gain, I thought the problem was changes in the regulation of body fat. I will maybe give it a try as I'm gaining weight every day.

Have you taken Remeron with T3? If so, any difference in mood with the T3?

/Mattias

> However, adding ranitidine (med against acid reflux) did actually stop the weight gain dead in it's tracks. Between psychiatrists this is a well known secret...
>
> Maria
>
> > I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?
> >
> > /Mattias
>
>

 

Re: T3 + Remeron + ranitidine

Posted by Maria3667 on January 10, 2008, at 15:26:59

In reply to Re: T3 + Remeron + ranitidine » Maria3667, posted by Phoenix1 on January 8, 2008, at 14:51:02

Hello Phoenix,

Yes there must be some literature on this, as it it common knowledge amonst therapists. The only link on hand I could find is this one:

www.neurotransmitter.net/mirtazapineweight.html

And I also speak from personal experience. The weight gain stopped when I started ranitidine. I can't remember the exact dose, but I think it was 2 tablets before each meal.

If it will stop MAO-weight gain?? No idea!
Maria

> > Hi Mattias,
> >
> > Do you want to adjunct with T3 because of weight gain? In my personal experience this wasn't effective...
> >
> > However, adding ranitidine (med against acid reflux) did actually stop the weight gain dead in it's tracks. Between psychiatrists this is a well known secret...
> >
> > Maria
> >
> > > I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?
> > >
> > > /Mattias
> >
> >
>
> Hi Maria,
>
> How much Ranitidine is required? Is there any literature on this? Do you think it would stop MAOI weight gain or is this a different mechanism?
>
> Thanks,
>
> Phoenix1

 

Re: T3 + Remeron + ranitidine » tensor

Posted by Maria3667 on January 10, 2008, at 15:30:33

In reply to Re: T3 + Remeron + ranitidine » Maria3667, posted by tensor on January 8, 2008, at 16:18:37

Hi,

Yes I took T3 together with Remeron and ranitidine. I have hypothyroidism so hence the T3. It didn't make any difference it weight nor mood, but it might to a person without thyroid troubles.

Cheers,
Maria

> > Do you want to adjunct with T3 because of weight gain? In my personal experience this wasn't effective...
>
> No, it's for boosting the antidepressant effect of my current AD's. That's the thought, i.e. I have been using H2 blockers like ranitidine and famotidine(Pepcid, which I prefer) for acid reflux which I get sometimes from hypnotics, but not long term. I have never thought of ranitidine as a way of avoiding weight gain, I thought the problem was changes in the regulation of body fat. I will maybe give it a try as I'm gaining weight every day.
>
> Have you taken Remeron with T3? If so, any difference in mood with the T3?
>
> /Mattias
>
>
>
> > However, adding ranitidine (med against acid reflux) did actually stop the weight gain dead in it's tracks. Between psychiatrists this is a well known secret...
> >
> > Maria
> >
> > > I have done some research about T3 as an augmentor to TCA and SSRI but I never see the combination of mirtazapine + T3 alone, is there anything, any study that contraindicates this treatment strategy?
> > >
> > > /Mattias
> >
> >
>
>

 

Re: T3 + Remeron + ranitidine » Maria3667

Posted by Phillipa on January 12, 2008, at 13:38:53

In reply to Re: T3 + Remeron + ranitidine » tensor, posted by Maria3667 on January 10, 2008, at 15:30:33

Maria very true as I also have thyroid disorder tried T3 with T4 and no weight loss more gain for me. Phillipa


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