Psycho-Babble Medication Thread 749134

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What's up inside my brain?

Posted by lukeds on April 11, 2007, at 18:48:35

Since 1994 when I was diagnosed with GAD, OCD, and dysthymia, I have been taking drugs like Nardil with bentazepam, in 1998 Nardil was quitted of sale in my country and I begun to take paxil with xanax. I was relatively ok, until 2003 when I developed an "Irritable bowel syndrome" and I begun to take sulpiride 50mg two times a day along the paxil and the xanax, but it never was like before, since 2003 I have been mild depressed, and in March of 2006 I begun to try different treatments for the refractory dysthymia without success (effexor, nardil again, citalopram, escitalopram, prozac, anafranil, and many more), also during the nardil trial I developed insomnia, so my psych added trazodone 50mg and distraneurin 2 pills before bed.

After all these failures, since three days I am taking fluvoxamine 100mg per day along with xanax 2mg per day, sulpiride 100mg per day, and for the insomnia 50mg of trazodone and two pills of distraneurin.

After read this article:
http://www.biopsychiatry.com/dopamine-d2.htm

"The present study aimed to determine whether, consistent with data from animal studies, the clinical antidepressant action of selective serotonin reuptake inhibitors (SSRIs) is reversed by acute administration of a receptor antagonist selective for D2-like receptors in the mesolimbic dopamine system."

I am very confused cause if the antidepressant effect of the SSRIs is reversed by drugs like sulpiride, so what do you advice me to do if I can't stop taking sulpiride because the pain caused by the Irritable bowel syndrome is insufferable, and I need to take the SSRIs cause I suffer from GAD, OCD and refractory dysthymia, so:

What's up inside my brain? And what can I do?

Also what's the difference inside the brain between a person with GAD, OCD and dysthimia but not with Irritable bowel syndrome, with me?

Lukeds.

 

Re: What's up inside my brain?

Posted by linkadge on April 11, 2007, at 18:54:23

In reply to What's up inside my brain?, posted by lukeds on April 11, 2007, at 18:48:35

Good question. I don't have a solid answer. I can say two things.

1. Sometimes antipsychotics can improve response to AD's. Sometimes they can make things a lot worse.

2. Amisulpride is slightly different from other antipsychotics in that it has higher affinity for presynaptic dopamine autoreceptors than it does for post synaptic receptors. So theoretically it could result in increased post-synaptic d2 receptor agonism. This may not be the case however.

I would personally go by what your gut tells you.

If paxil alone was working better, then you could try it alone. Perhaps add something else to help with the IBS. Perhaps low dose TCA, or mirtazapine might help.

Linkadge


 

Re: What's up inside my brain?

Posted by Declan on April 11, 2007, at 19:37:55

In reply to Re: What's up inside my brain?, posted by linkadge on April 11, 2007, at 18:54:23

It has been said that tianeptine is a treatment for IBS.

I don't know anything about that though.

 

Re: What's up inside my brain?

Posted by lukeds on April 11, 2007, at 21:34:21

In reply to Re: What's up inside my brain?, posted by linkadge on April 11, 2007, at 18:54:23

> 2. Amisulpride is slightly different from other antipsychotics in that it has higher affinity for presynaptic dopamine autoreceptors than it does for post synaptic receptors. So theoretically it could result in increased post-synaptic d2 receptor agonism. This may not be the case however.

What dosage of amisulpride do you recommend me to start to take instead of sulpiride? (The less the better?)

How long I will have to wait until amisulpride starts to work (approximately)?

Maybe that I have been taking sulpiride so many time that I need to up the dosage from 100mg to 200mg or more?

Also I have read that amisulpride affects dopamine d2 and d3, and sulpiride only d2.
How affects dopamine d3 the dysthymia and the IBS?

> I would personally go by what your gut tells you.

Absolutely I am the slave of my gut.

> If paxil alone was working better, then you could try it alone. Perhaps add something else to help with the IBS. Perhaps low dose TCA, or mirtazapine might help.

Paxil without sulpiride or with sulpiride doesn't work for me anymore. I have taken it after March of 2006 two times. The first from July to September of 2006, and although in the beginning it was well, after a month it pooped out.
The second, 8 weeks ago, and again at the beginnig it went well but after a month AGAIN it pooped out, so no more paxil forever.

Which TCA could be good for the IBS?

Only a bit of Mirtazapine sent me to a sleep of 16 hours, cause I take xanax too, and the interaction of benzodiazepines with Mirtazapine causes sleep and severe tiredness.

Lukeds.

 

Re: What's up inside my brain?

Posted by lukeds on April 11, 2007, at 21:42:09

In reply to Re: What's up inside my brain?, posted by Declan on April 11, 2007, at 19:37:55

> It has been said that tianeptine is a treatment for IBS.

Well I am impatient to prove tianeptine.

It is not sold in my country, so I had to buy it through an on-line Pharmacy in the Internet. I am waiting the shipment comes home.

Lukeds.

 

Re: What's up inside my brain? » lukeds

Posted by Phillipa on April 11, 2007, at 22:02:08

In reply to Re: What's up inside my brain?, posted by lukeds on April 11, 2007, at 21:42:09

IBS goes along with anxiety/depression had it almost all my life now I take magnesium at night. Good luck with your new regime. Lovse Phillipa


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