Psycho-Babble Medication Thread 745746

Shown: posts 1 to 12 of 12. This is the beginning of the thread.

 

How did Amineptine/nomifensine diffr vs stimulants

Posted by psychobot5000 on March 31, 2007, at 12:11:19

Since methylphenidate and amphetamine are both considered to act primarily through stimulating DA and NA release, and blocking their reuptake, and have long been distinguished from antidepressants...

Why were amineptine and nomifensine, which as far as I can tell acted via 'dopamine reuptake inhibition with additional effects on the adrenal system' (the former), and 'dopamine and NA reuptake inhibition' (the latter, which I note was approved even in the US) generally considered and prescribed as antidepressants?

Does anyone know of a difference in their mechanisms of action that would explain why those medications might have been more useful as antidepressants...or some other distinguishing quality?

Always in search of a good dopaminergic antidepressant,
psychbot

 

Re: How did Amineptine/nomifensine diffr vs stimulants

Posted by linkadge on March 31, 2007, at 13:28:08

In reply to How did Amineptine/nomifensine diffr vs stimulants, posted by psychobot5000 on March 31, 2007, at 12:11:19

Good question. I'm not entirely sure. I presume that something was limiting to nomifenasine's reward capacity.

I suspect Amineptine was more similar to stimulants in that it was taken off the market for abuse potential.

Am I correct in saying that nomifenasine was not discontinued for abuse potential.

Interestinly, not all dopamine reuptake inhibitors posess abuse potential. I was reading about a few invesitgational DRI's with little/no abuse potential. They didn't affect dopamine transporters in the neucleus accumbens and/or didn't produce a release of dopamine in such regions.

Linkadge

 

Re: How did Amineptine/nomifensine diffr vs stimul

Posted by rvanson on April 1, 2007, at 3:28:23

In reply to How did Amineptine/nomifensine diffr vs stimulants, posted by psychobot5000 on March 31, 2007, at 12:11:19

Merital/nomifensine was discontinued not because it didnt work but becuase a few people became ill or died due to an anemic condition.

It was not an addictive medication and more the any A/D is addictive.

 

Re: How did Amineptine/nomifensine diffr vs stimul rvanson

Posted by linkadge on April 1, 2007, at 9:10:45

In reply to Re: How did Amineptine/nomifensine diffr vs stimul, posted by rvanson on April 1, 2007, at 3:28:23

It is unfortunate, since I was under the impresson that it was a particularly effective medication for certain subgroups of depressed.

Linkadge

 

Re: How did Amineptine/nomifensine diffr vs stimul

Posted by rvanson on April 2, 2007, at 6:58:14

In reply to Re: How did Amineptine/nomifensine diffr vs stimul rvanson, posted by linkadge on April 1, 2007, at 9:10:45

> It is unfortunate, since I was under the impresson that it was a particularly effective medication for certain subgroups of depressed.
>
> Linkadge

It was very effective for major depression, treatment resistant depression and adhedonia/dysthymia conditions.

The side effect profile was low, particularly back in a time when TCA's and MAOI's were the main A/D Rx'ed for most people.

 

Re: nomifensine

Posted by psychobot5000 on April 3, 2007, at 13:19:04

In reply to Re: How did Amineptine/nomifensine diffr vs stimul, posted by rvanson on April 2, 2007, at 6:58:14

One has to wonder: if not for the side-effect of causing 'severe haemolytic anemia,' whether we'd all have another, better designed, catacholaminergic antidepressant in nomifensine, these days.

That said, I do not understand why a replacement for nomifensine never seems to have been in the pipeline. Was it just an exception, in its apparent lack of abuse potential? The market for it is there.

P-bot


> > It is unfortunate, since I was under the impresson that it was a particularly effective medication for certain subgroups of depressed.
> >
> > Linkadge
>
> It was very effective for major depression, treatment resistant depression and adhedonia/dysthymia conditions.
>
> The side effect profile was low, particularly back in a time when TCA's and MAOI's were the main A/D Rx'ed for most people.

 

Re: nomifensine

Posted by rvanson on April 6, 2007, at 11:50:33

In reply to Re: nomifensine, posted by psychobot5000 on April 3, 2007, at 13:19:04

> One has to wonder: if not for the side-effect of causing 'severe haemolytic anemia,' whether we'd all have another, better designed, catacholaminergic antidepressant in nomifensine, these days.
>
> That said, I do not understand why a replacement for nomifensine never seems to have been in the pipeline. Was it just an exception, in its apparent lack of abuse potential? The market for it is there.
>
My hunch is that since it was on the market on the EU before being launched in the US that it was "gotten rid of" by the Eli-Lilly brown-nosers at the FDA, as the new SSRI class med, Prozac was coming on-line in 1987.

The Big Pharma Co's have lots of clout and they are not as much concerned about your health as making $$$ for the stockholders.

Too bad the East Indian drug companies couldn't remanufacture this proven med, as I am sure it would be a nice addition for those who need a little Dopamine/NE punch in an AD.

Great med and worked very well for me until it was cancelled.

 

Re: nomifensine

Posted by psychobot5000 on April 6, 2007, at 13:45:42

In reply to Re: nomifensine, posted by rvanson on April 6, 2007, at 11:50:33

re: nomifensine
>
> ...as I am sure it would be a nice addition for those who need a little Dopamine/NE punch in an AD.
>
> Great med and worked very well for me until it was cancelled.
>

I'm curious. If you've taken stimulants or amineptine, or wellbutrin, I wouldn't mind to hear how it compared in terms of antidepressant effect, side-effects, etc.

psychbot


 

Re: nomifensine

Posted by rvanson on April 7, 2007, at 12:09:41

In reply to Re: nomifensine, posted by psychobot5000 on April 6, 2007, at 13:45:42

> re: nomifensine
> >
> > ...as I am sure it would be a nice addition for those who need a little Dopamine/NE punch in an AD.
> >
> > Great med and worked very well for me until it was cancelled.
> >
>
> I'm curious. If you've taken stimulants or amineptine, or wellbutrin, I wouldn't mind to hear how it compared in terms of antidepressant effect, side-effects, etc.
>
> psychbot

Never been on the stimulant class meds.

Just Reboxitine which made me angry and mad, not undepressed or capable of feeling happy again.

Kinda liked the feeling of being fighting mad as it beats being depressed, but if I had continued I would have beaten someone up or done something else stupid, like call some Teamsters Union mebers a bunch of @s$h$%#s (yeah, I really did that) :-)

Never had a chance to try amineptine before they banned it, but it sounds similar to what they did to Merital, they got rid of it because some people were using massive amounts to get a high.

Wellbutrin worked quite well for my depression/adhedonia and boosted my sex-drive for a number of years but increased anxiety as well. If not for the Xanax I could not have used Wellbutrin at all.

I finally had to give it up as it was causing massive GERD symptoms as I aged. My chest felt like it was on fire until I stopped using WB.

 

Re: nomifensine

Posted by rvanson on April 7, 2007, at 12:09:58

In reply to Re: nomifensine, posted by psychobot5000 on April 6, 2007, at 13:45:42

> re: nomifensine
> >
> > ...as I am sure it would be a nice addition for those who need a little Dopamine/NE punch in an AD.
> >
> > Great med and worked very well for me until it was cancelled.
> >
>
> I'm curious. If you've taken stimulants or amineptine, or wellbutrin, I wouldn't mind to hear how it compared in terms of antidepressant effect, side-effects, etc.
>
> psychbot

Never been on the stimulant class meds.

Just Reboxitine which made me angry and mad, not undepressed or capable of feeling happy again.

Kinda liked the feeling of being fighting mad as it beats being depressed, but if I had continued I would have beaten someone up or done something else stupid, like call some Teamsters Union mebers a bunch of @s$h$%#s (yeah, I really did that) :-)

Never had a chance to try amineptine before they banned it, but it sounds similar to what they did to Merital, they got rid of it because some people were using massive amounts to get a high.

Wellbutrin worked quite well for my depression/adhedonia and boosted my sex-drive for a number of years but increased anxiety as well. If not for the Xanax I could not have used Wellbutrin at all.

I finally had to give it up as it was causing massive GERD symptoms as I aged. My chest felt like it was on fire until I stopped using WB.

 

Re: wellbutrin rvanson

Posted by psychobot5000 on April 7, 2007, at 13:44:06

In reply to Re: nomifensine, posted by rvanson on April 7, 2007, at 12:09:58

>
> I finally had to give it up as it was causing massive GERD symptoms as I aged. My chest felt like it was on fire until I stopped using WB.
>
>

Ever tried using proton pump inhibitors to combat the GERD? ADs generally give me stomach trouble, but I found them very effective at preventing that--protonix/pantoprazole, prilosec/omeprazole, prevacid/lansoprazole, aciphex/rabeprazole, nexium. If they don't work well enough (they're considered pretty effective, though), just raise the dose. Maybe they could make the Wellbutrin tolerable, as it sounds like it worked well for you.

 

Re: wellbutrin

Posted by rvanson on April 10, 2007, at 17:51:30

In reply to Re: wellbutrin rvanson, posted by psychobot5000 on April 7, 2007, at 13:44:06

> >
> > I finally had to give it up as it was causing massive GERD symptoms as I aged. My chest felt like it was on fire until I stopped using WB.
> >
> >
>
> Ever tried using proton pump inhibitors to combat the GERD? ADs generally give me stomach trouble, but I found them very effective at preventing that--protonix/pantoprazole, prilosec/omeprazole, prevacid/lansoprazole, aciphex/rabeprazole, nexium. If they don't work well enough (they're considered pretty effective, though), just raise the dose. Maybe they could make the Wellbutrin tolerable, as it sounds like it worked well for you.

Yes, I tried that route, but apparently I have a predisposition to GERD that the WB set off. It took months for my reflux to settle down so Wellbutrin is out for me.


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