Psycho-Babble Medication Thread 645682

Shown: posts 1 to 15 of 15. This is the beginning of the thread.

 

How long have MAOI's been used for?

Posted by nickguy on May 18, 2006, at 21:13:47

Anybody have any idea how long these have been around for?


(I tried searching "maoi history" on google, but kept getting things like "maoi have a history of..." blah blah blah)

 

Re: How long have MAOI's been used for?

Posted by Jost on May 18, 2006, at 21:27:40

In reply to How long have MAOI's been used for?, posted by nickguy on May 18, 2006, at 21:13:47

From wikipedia:

"Iproniazid (iproniazid phosphate, marketed under the names Marsilid®, Iprozid®, Ipronid®, Rivivol®, Propilniazida®) is a monamine oxidase inhibitor (MAOI) that was developed as the first anti-depressant. It was originally intended to treat tuberculosis when it was discovered that patients given iproniazid became "inappropriately happy," subsequently with further research iproniazid was marketed specifically for depression in 1958. It was later replaced by less hepatotoxic drugs."

Jost

 

Re: How long have MAOI's been used for?

Posted by Declan on May 18, 2006, at 21:30:40

In reply to How long have MAOI's been used for?, posted by nickguy on May 18, 2006, at 21:13:47

I was looking for an answer to your question in "Review of medical Pharmacology" and found no answer, but it would have to be 50 years. But listen to this:
"The MAO inhibitors have been almost completely superceded by the antidepressants related to tranquillizers. In retrospect it is doubtful that even iproniazid had significant usefulness in major depressions. Indeed there are many studies that question whether the Hydrazines are superior to placebos." Doses for Nardil are given as 30-45mg, then 5-20mg. Parnate is given as 20mg initially and 10-20 maintenance.
Blast from the past, eh? Published 1968.

 

Re: How long have MAOI's been used for?

Posted by Phillipa on May 18, 2006, at 21:55:32

In reply to Re: How long have MAOI's been used for?, posted by Declan on May 18, 2006, at 21:30:40

I didn't know they harmed the liver. Better reason for the patch as it bypasses internal organs. Love Phillipa

 

Re: How long have MAOI's been used for?

Posted by nickguy on May 18, 2006, at 22:48:06

In reply to Re: How long have MAOI's been used for?, posted by Phillipa on May 18, 2006, at 21:55:32

my psychiatrist has been practicing for about 30 years, so I'm guessing he's prescribed an maoi a couple of times. Does anybody know how long after the tricyclics came out? I think the ssri's were in the 80's, but i'm not positive.

 

Re: How long have MAOI's been used for? » nickguy

Posted by Phillipa on May 18, 2006, at 22:55:59

In reply to Re: How long have MAOI's been used for?, posted by nickguy on May 18, 2006, at 22:48:06

I think early 90's by where I lived. I moved to Va Beach in l987 not out. Lived there two years. Moved to Chesapeake and a year or two after the doc prescribed prozac when it only came in the 20mg gel dose. Love Phillipa of course it could have been out longer

 

Re: How long have MAOI's been used for? » nickguy

Posted by Racer on May 19, 2006, at 1:31:43

In reply to Re: How long have MAOI's been used for?, posted by nickguy on May 18, 2006, at 22:48:06

TCAs were first marketed not long after the MAOIs. I'm not sure exactly when, but both classes were around by the 60s, and SSRIs came out in the late 80s. Wellbutrin is actually about the same vintage, as I recall -- I know it's surprisingly old, really.

It's an interesting subject, ain't it?

 

Re: How long have MAOI's been used for?

Posted by JaclinHyde on May 19, 2006, at 13:46:02

In reply to Re: How long have MAOI's been used for?, posted by Declan on May 18, 2006, at 21:30:40

I don't know of any class of AD out there that isn't a bit hard on the liver. Ok, maybe there are some but if it isn't the liver then its some other organ. Hell, if you stay on aspirin (regular dose, not the baby kind) too long your stomach will really start to complain. Truth is: there is no such thing as a completely safe drug.

The MAOI's are the oldest class of drugs and therefore we know more about them than any other class. For all we know in 20 years time everyone who took....oh let's say Effexor (just picking one at random!) will have 2 headed babies or something!

JH

 

Re: How long have MAOI's been used for? » Racer

Posted by Phillipa on May 19, 2006, at 13:59:07

In reply to Re: How long have MAOI's been used for? » nickguy, posted by Racer on May 19, 2006, at 1:31:43

Racer I thought it could have been the late 80's but prozac was the first ad for me so I wasn't sure how long it had acturally been available. Oh do you know when they came out with the low does pills of prozac? Love Phillipa

 

Re: How long have MAOI's been used for? » JaclinHyde

Posted by Declan on May 19, 2006, at 21:41:25

In reply to Re: How long have MAOI's been used for?, posted by JaclinHyde on May 19, 2006, at 13:46:02

Hi JH
Agreed. I was just astonished that there would be such unreliable guidance given to clinicians in the late 60s. The doses were really low, and the suggestian that the hydrazines were less effective than placebo....well, on the doses given, maybe. I'd been thinking I didn't make my intentione very clear. I was trying to find out when iproniazid was first used.
Declan

 

Re: How long have MAOI's been used for?

Posted by Jost on May 19, 2006, at 22:20:30

In reply to Re: How long have MAOI's been used for? » JaclinHyde, posted by Declan on May 19, 2006, at 21:41:25

Another website offered this information:


" Iproniazid was found by chance to have a marked effect on depressive symptoms in TB patients, so much so that it was soon superseded by another less stimulating drug, (and finally withdrawn by the manufacturers in 1961, when found to cause liver damage):

"It was eventually displaced by isoniazid since iproniazid actually made some of the patients feel ‘too well’ with the result that they failed to observe ordinary precautions, overexerted themselves, or discontinued treatment prematurely. Retrospectively it is evident that the drug not only relieved depression but occasionally must have induced euphoria. In view of the excessive good spirits of the patients it is strange that at the time the emotional reaction was regarded as a detrimental side effect and no one tried using iproniazid for treatment of depression". (Kline, 1964)"

My understanding was that various reported instances of hypertensive crises, which were not fully evaluated and studied, caused most physicians to reject maois. At least until more recently.

Jost

 

Re: How long have MAOI's been used for?

Posted by linkadge on May 20, 2006, at 1:52:19

In reply to Re: How long have MAOI's been used for?, posted by Jost on May 19, 2006, at 22:20:30

It always suprised me how negitively doctors and researchers react to the antidepressants that tend to make patients feel slightly better than well.

Goodness knows we have enough antidepressants that don't work well enough.

Its not as if you see doctors saying, "uh-oh, this heart medication went to far. It seems that it is giving our patients the hearts of a 20 year old Swiss man. Well, we've just got to take this one off the market."

Linkadge


 

Re: How long have MAOI's been used for?

Posted by JaclinHyde on May 20, 2006, at 10:39:28

In reply to Re: How long have MAOI's been used for?, posted by linkadge on May 20, 2006, at 1:52:19

LOL, so true! Great observation!

JH

> Its not as if you see doctors saying, "uh-oh, this heart medication went to far. It seems that it is giving our patients the hearts of a 20 year old Swiss man. Well, we've just got to take this one off the market."
>
> Linkadge
>
>
>

 

Re: How long have MAOI's been used for?

Posted by Jost on May 20, 2006, at 10:49:42

In reply to Re: How long have MAOI's been used for?, posted by JaclinHyde on May 20, 2006, at 10:39:28

Well, we can't have any of that "euphoria" getting in the way of people's ordinary unhappiness...

Jost

 

Re: How long have MAOI's been used for?

Posted by JaclinHyde on May 20, 2006, at 12:30:31

In reply to Re: How long have MAOI's been used for?, posted by Jost on May 20, 2006, at 10:49:42

:-)

JH


> Well, we can't have any of that "euphoria" getting in the way of people's ordinary unhappiness...
>
> Jost


This is the end of the thread.


Show another thread

URL of post in thread:


Psycho-Babble Medication | Extras | FAQ


[dr. bob] Dr. Bob is Robert Hsiung, MD, bob@dr-bob.org

Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.