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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by tgo on April 19, 2006, at 8:13:41
Does anyone know which would be better to try for social anxiety, sulpiride or amisulpride?
Posted by jparsell82 on April 19, 2006, at 10:26:22
In reply to Which is better Sulpiride or Amisulpride?, posted by tgo on April 19, 2006, at 8:13:41
> Does anyone know which would be better to try for social anxiety, sulpiride or amisulpride?
They seemed very similar feeling to me. I think I liked Amisulpride a little bit better.
Posted by vale on April 19, 2006, at 13:37:26
In reply to Re: Which is better Sulpiride or Amisulpride?, posted by jparsell82 on April 19, 2006, at 10:26:22
Both are substituted benzamide neuroleptics,and as such carry the dangers of neuroleptics( weight gain, prolactin elevation, muscle rigidity, the shakes, etc.) I've tried them both. Sulperide is the older of the two. Both are disinhibitory at the lower dose range, but amisulperide is a definite improvement, very fast acting it's effects are noticed within hrs, and this drug can make you feel better than well in a short space of time if it suits you. But there is a snag, as stopping it can make you feel a lot worse than a bout of social phobia does. I know it's used for syndromes as mild as dysthymia, but think carefully before you start. Consider drugs a last option, consider antipychotics as the last of the last options.
take care
Posted by tgo on April 19, 2006, at 14:36:37
In reply to Re: Which is better Sulpiride or Amisulpride?, posted by vale on April 19, 2006, at 13:37:26
Vale, did you have a bad experience with this med? Do you mean a person wil feel worse each day when it wears off or that a person will feel worse after you discontinue the med? I've read a lot of posts about it and I'm desperate for something that will help my condition, particularly so I can get a job again.
> Both are substituted benzamide neuroleptics,and as such carry the dangers of neuroleptics( weight gain, prolactin elevation, muscle rigidity, the shakes, etc.) I've tried them both. Sulperide is the older of the two. Both are disinhibitory at the lower dose range, but amisulperide is a definite improvement, very fast acting it's effects are noticed within hrs, and this drug can make you feel better than well in a short space of time if it suits you. But there is a snag, as stopping it can make you feel a lot worse than a bout of social phobia does. I know it's used for syndromes as mild as dysthymia, but think carefully before you start. Consider drugs a last option, consider antipychotics as the last of the last options.
>
> take care
Posted by vale on April 19, 2006, at 17:18:36
In reply to Re: Which is better Sulpiride or Amisulpride?, posted by tgo on April 19, 2006, at 14:36:37
tgo, both sulperide ( Dogmatil) and amisulperide (Solian) I reckon would be unsustainable in the long term in the abscence of severe illness. ( like negative state schizophrenia or pychotic depression) You see at some point one stops from either bothersome side effects, or one simply adapts to the effects and the negative feedback loop kicks in, and the drug doesn't work or not as well. Some people can get off these drugs easily, others not so. If you have any recent history of using SSRI antidepressants , you risk being one of the unlucky ones. This may have been my mistake. Seems to make one supersensitive to both the good and the bad aspects of the drug. Takes about 6 months to be clear of the negative effects after stopping.
Muscle tension, esp. the jaw, neck muscle ridigity, stress sensitivity, general dysthymia.
Too many variables inherant in your comment about being desperate to get a job, ie. something to help you get over a tough interview or help to get you working with people on a daily basis.
If you have to, take something safer like Modafinal ( Provigil)and/or Tianeptine ( Stablon) Both a hell of a site easier to stop than neuroleptics.
Good luck
Posted by blueberry on April 19, 2006, at 20:46:51
In reply to Which is better Sulpiride or Amisulpride?, posted by tgo on April 19, 2006, at 8:13:41
I tend to agree with the other posters on amisulpride. I have tried it a couple times. Never tried sulpiride, but it is supposed to be quite similar.
With amisulpride you get almost instant improvement similar to a stimulant, due to the new surge of dopamine it creates. Then you quickly develop tolerance to that in just a couple days, similar to a stimulant. After about a month, changes in the brain receptors take place that result in calm and peace and good mood. But how long that would continue, I don't know. For me I went about 2 months until the sexual side effects and insomnia got the best of me and I tapered off.
As was already mentioned, if it doesn't work out, coming off of it is real bad. That's because your brain will be full of dopamine. Even if it doesn't help you, it is still full of dopamine. When that dopamine level starts to fall, look out below. You're talking serious desperate uncontrollable crying sobbing despair kind of depression. For me it lasted about 3 days and I was sure I was going to the hospital. Somehow I survived.
Honestly though I have had similar experiences coming off other meds and even herbs too. It is a high risk game. Hopefully you find something that works good enough, keeps working, has decent side effects, and you never have to worry about it. Maybe amisulpride can do that, maybe not. Don't know.
This is the end of the thread.
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