Psycho-Babble Medication Thread 627145

Shown: posts 1 to 16 of 16. This is the beginning of the thread.

 

MAOI USERS PLEASE READ!!!

Posted by JaclinHyde on March 31, 2006, at 14:58:40

Do not take Benadryl with MAOI's. I never realized this myself until I was doing a little check of Tylers meds on Medscape. FATALITIES HAVE OCCURED!! Read the post to Tyler above this one to understand how this all works. Claritin and Zyrtec are both ok with MAOI's.

::This has been a public service announcement to all my MAOI buddies::

Stay well,
JH

 

Re: MAOI USERS PLEASE READ!!!

Posted by greywolf on March 31, 2006, at 15:21:30

In reply to MAOI USERS PLEASE READ!!!, posted by JaclinHyde on March 31, 2006, at 14:58:40

The doctor should have taken care to explain this. The pharmacist, too. It's basic knowledge necessary for anyone taking an MAOI.

Every Benadryl medication contains a clear warning that it must not be taken with an MAOI. The patient information sheets for Nardil and Parnate warn not to take cold, allergy, hay fever, and decongestant medications unless first cleared by a doctor.

When I started Nardil, my doctor sat me down and explained all the food issues and potential med interactions including OTC meds, and made me promise to follow the rules. When I picked up my scrip, the pharmacist took me aside and gave me the same lecture. Both of them told me to call the doc to get prior approval of any OTC meds for colds, allergies, etc.

 

Re: MAOI USERS PLEASE READ!!!

Posted by SLS on March 31, 2006, at 15:42:48

In reply to Re: MAOI USERS PLEASE READ!!!, posted by greywolf on March 31, 2006, at 15:21:30

I'm having trouble finding anything that describes an interaction or reports an untoward event when tranylcypromine and diphenhydramine are combined. All that comes up are the manufacturer's warnings.

I've combined these two drugs without incidence. Of course, this is only one person. However, this contraindication is news to me. I'm surprised by it.

Live and learn...


- Scott

 

Re: MAOI USERS PLEASE READ!!! » SLS

Posted by ed_uk on March 31, 2006, at 16:12:15

In reply to Re: MAOI USERS PLEASE READ!!!, posted by SLS on March 31, 2006, at 15:42:48

Hi Scott,

Pharmaceutical companies frequently 'invent' drug interactions simply because they haven't studied the interaction. This is especially true of MAOIs. Some of the alleged MAOI drug interactions are fantasy, not reality. Because MAOIs have numerous *major* drug interactions, many pharmaceutical companies have chosen to state that their products are contra-indicated with MAOIs, despite the absense of any evidence of an interaction.

I have read than diphenhydramine is a weak monoamine reuptake inhibitor. As a result, I would advise against combining it with MAOIs. There are many alternative antihistamines. None of the newer non-sedating antihistamines interact with MAOIs. Steroid nasal sprays do not interact with MAOIS. In patients being treated with MAOIs, diphenhydramine would not be the most suitable treatment for insomnia. Other meds, such as zolpidem (Ambien) would generally be more appropriate.

WARNING........

Benadryl is used as a brand name for MANY different OTC products, some of which contain decongestants as well as diphenhydramine. Decongestants can cause a hypertensive crisis when administered with an MAOI.

Ed

 

Re: MAOI USERS PLEASE READ!!!

Posted by willyee on March 31, 2006, at 18:23:19

In reply to Re: MAOI USERS PLEASE READ!!! » SLS, posted by ed_uk on March 31, 2006, at 16:12:15

I think Ed has the best answer......personaly i never had an interaction between them,but god does bendarly make me feel horrable on maois.

As far as otc no sleep meds seem to go well,like ed said ambien works the best,i take half an ambien and at that point adding anything in that is safe works with a synergy to ambien,these were small pieace of klonopin,small amount of l theanine,taurine,nuerotion etc...

If u want to cut back on ambien,or perhaps not be too relieant on it,try slowly adding a known safe gaba drug to a partial ambien.

I recomend this on the users own resonsability.

Note: One thing im surprised about is taking a caffiene tab,both No -doz and Vivarin go fine with parnate,nothing bad at all worst expected ocd type behaviour but nothing maniac like a amphetmaine,im surprised because even on the bottle caffiene is contradicted.

 

Re: MAOI USERS PLEASE READ!!!

Posted by djmmm on March 31, 2006, at 19:18:27

In reply to MAOI USERS PLEASE READ!!!, posted by JaclinHyde on March 31, 2006, at 14:58:40

benadryl is perfectly fine to take with MAOIs...trust me, I take it nightly. I would be very surprised if anyone here has had any type of negative reaction to this combo. FWIW, the vast majority of MAOI "no-no's" are exaggerated. Many people combine stimulants, TCA's, and several other "contraindicated" medications with MAOIs.

 

Re: MAOI USERS PLEASE READ!!!

Posted by willyee on March 31, 2006, at 20:06:55

In reply to Re: MAOI USERS PLEASE READ!!!, posted by djmmm on March 31, 2006, at 19:18:27

Right but were forgetting about what if a person is the ONE,the reactions are not a game,they are dead serious,i had one,u dont know what to do,what to take,everything makes u feel worse,ur head pounds so hard u can feel the veins pulsating........i was laying down with a family member next to me and we looked at my foot and a small vein in my foot was pulsating like a drum,it looked like it was dancing,my chest tightened up,and i could imagine the pain leading to brain hemorage.

We can saying how nothing happens,but like someone on a plane wreck,yess its unlikly to happen but we still have to check baggage etc and do extreme measure to passegners on even the simplest flights,why? cause even though its general safe IF something does happen its extreme,


A lot of readers may be silent ones,newbies about to take an maoi,not a person whos been on many meds and is a veteran,and this person should follow most of the guidlines set for maois for a long enough time till they feel comfortable,dont start these maois using benadryl and other stuff,take it slow and follow the guidlines,an interaction IS NOT something u want to have,when it starts u can wish u werent so ready to test the maoi rules.

Just my two cents,i just see we went from acknowledging the maoi guidelines are a bit extreme which is good,to now what im seeing is a dangerous almost total disregard to them,its playing with fire people u dont wanna have one!

Good luck to all be safe and use numerous resources including ur doc when u use ur medication.

 

Re: MAOI USERS PLEASE READ!!!

Posted by willyee on March 31, 2006, at 20:13:16

In reply to Re: MAOI USERS PLEASE READ!!!, posted by willyee on March 31, 2006, at 20:06:55

P.S i was in ER for the first time ever due to meds when i combined Ritalin and Parnate.I slowly become totaly maniac,not sleeping for 4 days,stuck to my computer with ocd working on stupid things,not acnkowledging my hygeiene or the outside world,i felt great dident even know how many parnate i even was taking from that point.

Finaly i chrashed and had sleep in increments which included cycling nightmares,meaning id literaly just fall asleep and into a specific nightmare,wake up thinking it was real,and repeat.

I was going crazy.So there is good reason not to combine stimulants with parnate,its is TOTALY dangerous and should be done with someone either the patient or doc following every step,it is NOT for the first time user of parnate,combing these are a recipe for disaster long term.

I would say someone in a rut,guided by a very nowledgable docter can combine them even dexa but i think it should be cycled,once mood improvment is achieved the stimulant should be stopped and used this way.

Just my opinion but there are way more respected documents that hail this combo as deadly then there are the few pages on the web where this was done.

 

Re: MAOI USERS PLEASE READ!!!

Posted by tygereyes on April 2, 2006, at 4:51:50

In reply to Re: MAOI USERS PLEASE READ!!!, posted by willyee on March 31, 2006, at 20:13:16

Strange - I took 200 mg of Benadryl (I have SEVERE insomnia) with 80 mg Parnate for a while and I was fine.

 

I've had no trouble w/ Benadryl and Nardil

Posted by gardenergirl on April 2, 2006, at 9:07:24

In reply to Re: MAOI USERS PLEASE READ!!!, posted by tygereyes on April 2, 2006, at 4:51:50

I have taken 50 mg of diphenhydramine, which is marketed under the brand name Benadryl, while on Nardil. I've had no adverse reactions to combining the two. I seldom take Benadryl, though, because it usually makes me drowsy for about an hour or so, then I get somewhat restless. I'm weird that way I guess.

It's important, as others have said, to read OTC medicines carefully. There are so many combinations of meds out there under each brand name. Cough medicines are the same. Those of us on MAOI's have to make sure there is no dextramathorphan (sp?) in any cough meds we take.

Between reading food packages and meds ingredients, I've become quite good at reading small print under those darned fluorescent lights at the stores.

Take care everyone,

gg

 

Re: MAOI USERS PLEASE READ!!! » tygereyes

Posted by TylerJ on April 2, 2006, at 10:26:54

In reply to Re: MAOI USERS PLEASE READ!!!, posted by tygereyes on April 2, 2006, at 4:51:50

> Strange - I took 200 mg of Benadryl (I have SEVERE insomnia) with 80 mg Parnate for a while and I was fine.

Wow, that's a lot of Benadryl!

 

Re: MAOI USERS PLEASE READ!!!

Posted by tygereyes on April 2, 2006, at 17:10:06

In reply to Re: MAOI USERS PLEASE READ!!! » tygereyes, posted by TylerJ on April 2, 2006, at 10:26:54

> > Strange - I took 200 mg of Benadryl (I have SEVERE insomnia) with 80 mg Parnate for a while and I was fine.
>
> Wow, that's a lot of Benadryl!

Yeah, I started taking Ambien not too long after.

It's funny, though, Parnate gave me akathesia, and Benadryl made it FIFTY MILLION times worse, even though it's supposed to help.

 

Re: MAOI USERS PLEASE READ!!! » tygereyes

Posted by TylerJ on April 2, 2006, at 17:17:50

In reply to Re: MAOI USERS PLEASE READ!!!, posted by tygereyes on April 2, 2006, at 17:10:06

> > > Strange - I took 200 mg of Benadryl (I have SEVERE insomnia) with 80 mg Parnate for a while and I was fine.
> >
> > Wow, that's a lot of Benadryl!
>
> Yeah, I started taking Ambien not too long after.
>
> It's funny, though, Parnate gave me akathesia, and Benadryl made it FIFTY MILLION times worse, even though it's supposed to help.

Really. I've never experienced akathesia with Parnate. I'm just the opposite..it really relaxes me, which is nice after 25 plus years of anxiety.

 

Re: MAOI USERS PLEASE READ!!!

Posted by willyee on April 2, 2006, at 18:27:22

In reply to Re: MAOI USERS PLEASE READ!!!, posted by tygereyes on April 2, 2006, at 17:10:06

Wierd drug,depending on unknown factors im still trying to pinpoint,parnate can stop anxiety or it can induce it,just depends on time,dose etc..

I say etc cause im not sure really what makes this difference in effect,and trust me i have brainstormed trying to narrow it down

 

Re: MAOI USERS PLEASE READ!!!

Posted by JaclinHyde on April 2, 2006, at 19:51:56

In reply to Re: MAOI USERS PLEASE READ!!!, posted by willyee on April 2, 2006, at 18:27:22

If youu want to talk about dangerous reactions I had gotten a shot of demerol when I was a kid on Nardil. My shrink went balliestic because he know thhat my other doc knew thhat I was on it. Luckily nothing happens. But that doesn't mean that it wouldn't happen in the future. Jusr be careful.

JH

 

Re: MAOI USERS PLEASE READ!!!

Posted by jedi on April 3, 2006, at 1:00:32

In reply to Re: MAOI USERS PLEASE READ!!!, posted by JaclinHyde on April 2, 2006, at 19:51:56

Hi Guys,
I have taken straight Benadryl(diphenhydramine hydrochloride) for years with Nardil. I don't believe they are contraindicated. MAOI's may intensify the anticholinergic effects of Benadryl.

Read the fine print carefully. They like to sneak in things like pseudoephedrine, which is a definate NO-NO! One time I bought some codeine cough syrup in Canada, over the counter. Since Nardil makes my presbyopia worse, I could not read the fine print. I asked the pharmacist and she assured me it was fine with Nardil. Wrong! The cough syrup contained pseudoephedrine and I ended up in the ER with a hypertensive crisis. Moral of the story: Do not trust anybody when it comes to MAOIs. You must be willing to go the extra mile when taking these meds. The buck stops with you. It is your life.
Jedi

LINK:
http://www.nhtsa.dot.gov/PEOPLE/injury/research/job185drugs/diphenhydramine.htm
Drug Interactions: Effects of diphenhydramine are increased by the presence of alcohol, MAOI’s, diazepam, hypnotics, sedatives, tranquilizers, and other CNS depressants. Alcohol enhances such effects as drowsiness, sedation and decreased motor skills. These decrements in effect are more pronounced in the elderly.

MAOI’s prolong and intensify the anticholinergic effects of diphenhydramine.


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