Psycho-Babble Medication Thread 607524

Shown: posts 1 to 5 of 5. This is the beginning of the thread.

 

ValdoxanŽ (agomelatine)

Posted by Sonny Liston on February 8, 2006, at 12:50:22

What are the chances the FDA approving this novel compound for depression?

ValdoxanŽ (agomelatine), the first melatonergic (MT1 and MT2 receptor) agonist antidepressant, is an innovation in the treatment of depression with several advantages over existing treatments according to data presented during the 13th Congress of the Association of European Psychiatrists. Besides being an effective antidepressant, Valdoxan has shown particular advantages in improving the often disrupted sleep patterns of depressed patients, without affecting daytime vigilance.

Valdoxan was discovered and developed by Servier. The drug is currently in Phase III and a registration dossier for an indication in MDD was recently submitted to the European Regulatory Agency (EMEA).

Servier also markets Stablon.

 

Re: ValdoxanŽ (agomelatine)

Posted by ed_uk on February 8, 2006, at 13:28:24

In reply to ValdoxanŽ (agomelatine), posted by Sonny Liston on February 8, 2006, at 12:50:22

Only a few of Servier's drugs seem to be available in the US. I wonder why?

Ed

 

Re: ValdoxanŽ (agomelatine)

Posted by linkadge on February 8, 2006, at 15:31:40

In reply to Re: ValdoxanŽ (agomelatine), posted by ed_uk on February 8, 2006, at 13:28:24

Does the drug have any other properties ? Also, doesn't melatonin itself agonize M1, M2 ?

I wonder what a back to back comparison with melatonin would yield ?

Linkadge

 

Re: ValdoxanŽ (agomelatine)

Posted by Sonny Liston on February 8, 2006, at 16:26:08

In reply to ValdoxanŽ (agomelatine), posted by Sonny Liston on February 8, 2006, at 12:50:22

Ed,

I was wondering the same thing about Servier's drugs. I think they are a pretty Substantial player in the Global drug market. I'm not sure if they came up with Milnacipran also? I think Forest and Cypress biospace are trying to steal that one.

Maybe they don't like dealing with the FDA? Who knows, but it's a shame.

Linkadge,

If you google "Valdoxan" you'll find an abundance of information (you may already have)

I just get the feeling this one is never going to make it here (U.S.).....

 

Re: ValdoxanŽ (agomelatine)

Posted by SLS on February 8, 2006, at 19:30:20

In reply to Re: ValdoxanŽ (agomelatine), posted by linkadge on February 8, 2006, at 15:31:40

* methoxynaphthyl ethylacetamide:
5-HT2b antagonist ++
5-HT2c antagonist +++
melatonin M1 receptor agonist +++
melatonin M2 receptor agonist +++


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