Psycho-Babble Medication Thread 578255

Shown: posts 1 to 7 of 7. This is the beginning of the thread.

 

Do you think more benzo's will come on the market?

Posted by rjlockhart on November 13, 2005, at 15:57:52

Well for now i havent seen any.
Lunesta is newest in benzodiazepine related drugs.
But no actual benzodiazepines have been introduced.

Xanax was released in 1981, thats the last. Klonopin came out in '75 as a antiepileptic.
What are really the doctors thinking, SSRI's made there hit, but i dont know if there going to come out with more, proably.

I imagine if they do, (benzo's) it would more complex in its actions, maybe treat certain disorders besides anxiety,more OCD, some that work on serotonin receptors and GABA.
I think the market is hestitant to make new tranquilzers becuase they have already made there history. But i think they should, Klonopin is antimanic but makes me depressed beyound reality.
Well what you think?
Matt

 

Re: Do you think more benzo's will come on the market?

Posted by lunesta on November 13, 2005, at 19:54:36

In reply to Do you think more benzo's will come on the market?, posted by rjlockhart on November 13, 2005, at 15:57:52

ocinaplon, the next revolutionary non benzo, benzo. It targets only anxiety receptors selectively! should be out in the next few years

 

Re: wow

Posted by rjlockhart on November 13, 2005, at 20:11:46

In reply to Re: Do you think more benzo's will come on the market?, posted by lunesta on November 13, 2005, at 19:54:36

Wow that intresting, so it wouldnt produce sedation? i was thinking they would come out with a benzodiazepine that will target serotonin receptors?

Do you think they will actually come out with more benzodiazepines?

 

Re: Do you think more benzo's will come on the mar

Posted by med_empowered on November 13, 2005, at 21:06:01

In reply to Do you think more benzo's will come on the market?, posted by rjlockhart on November 13, 2005, at 15:57:52

who knows. My guess would be that any benzo/benzo-ish compount that hits the market soon would have to do more than just treat anxiety (thats a big deal in and of itself, but still..)...I think what would be really nice is 1 pill for combined depression/anxiety; if this medication could also help with subtypes of anxiety (ex: social phobia) or maybe provide a little bit of mood stabilization, that'd be nice, too. The ideal new-age benzo could be taken as-needed, would have minimal withdrawal issues, and would play well with other drugs, since psychiatric cocktails are so popular. Hopefully, these new meds would also help with some more severe problems, like schizophrenia and bipolar (klonopin and ativan do a bit for these disorders). Perhaps most importantly, the ideal benzo would either be unscheduled--which would be **AWESOME**--or would be scheduled but not regarded as problematic (ex: Ambien is schedule IV, but no one really regards Ambien as a "drug"; the scheduling seems more like a technicality).

 

Re: Do you think more benzo's will come on the mar

Posted by Phillipa on November 13, 2005, at 21:56:51

In reply to Re: Do you think more benzo's will come on the mar, posted by med_empowered on November 13, 2005, at 21:06:01

Are you all talking about my "Magic Pill"? And we all could live in Babbleland. And babble all day long. What a great support group we'd be. Just like the hippies in the 60's. Have our own civilization. Fondly, Phillipa

 

Re: Do you think more benzo's will come on the mar

Posted by rjlockhart on November 13, 2005, at 22:07:37

In reply to Re: Do you think more benzo's will come on the mar, posted by Phillipa on November 13, 2005, at 21:56:51

Phillipa,

Did you take you Diazepam? ROFL

Sounds like you took 15mg. hehe

I took 2mg of Clonazepam and 30mg of Restoril.

I feel like talking.

I think Valium will still be used till 2060.

Matt

 

Tofisopam (Grandaxin) - a Hungarian benzo

Posted by ed_uk on November 14, 2005, at 13:39:26

In reply to Do you think more benzo's will come on the market?, posted by rjlockhart on November 13, 2005, at 15:57:52

Hi everyone,

Tofisopam (Grandaxin), a 2,3-benzodiazepine, is very different to the familiar 1,4-benzodiazepines eg. Klonopin, Ativan, Valium etc. Tofisopam was invented in Hungary.

Tofisopam isn't marketed in the US, it's supposedly quite a popular anti-anxiety drug in Hungary though. Darkhorse tried it, I think he liked it.

R-tofisopam, the R-isomer of tofisopam, is currently being studied as a treatment for anxiety. It might be available in the US at some point in the future.

Tofisopam does not bind to the same receptors as 1,4-benzodiazepines such as Klonopin.

Acta Pharm Hung. 1993 Mar;63(2):91-8.

Excerpts from the clinical-pharmacologic and clinical studies of Grandaxin

Szego J, Somogyi M, Papp E.

EGIS Gyogyszergyar Rt., Budapest.

The authors give a selection from the clinical-pharmacological and clinical studies of Grandaxin (tofizopam), an original Hungarian compound registered in 1976. Tofizopam, a 2,3-benzodiazepine derivative, differs from "classical" 1,4-benzodiazepines not only in chemical structure, but also in pharmacological and clinical-pharmacological properties. It is an anxiolytic without sedative-hypnotic, muscle relaxant and anticonvulsive effects. Tofizopam does not impair psychomotor and intellectual performance, like other benzodiazepines do, in the contrary, it has a mild stimulatory activity. It is potent in alleviating vegetative symptoms accompanying anxiety disorders. Tofizopam has a very low toxicity, mild side effects. The administration of tofizopam does not lead to physical or psychic dependence.

Ed


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