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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Jaydee on September 2, 2005, at 23:09:00
It seems that SSRI's are good at decreasing Frontal Lobe activity. this seems to be a long term usage side effect (experienced myself) Id say that frontal lobe activity was actually increased in the first 5 months, then downhill.
Can you give me any links to studies that confirm this?
and on MAOI's, particulalry phenelzine. Do they suffer from this same fault? any studies on it?
TIA
Posted by linkadge on September 3, 2005, at 6:59:24
In reply to Linkadge-AD/Frontal Lobe help?, posted by Jaydee on September 2, 2005, at 23:09:00
This link has some info on the occurance.
http://www.antidepressantsfacts.com/frontal-lobe-syndrome.htm
Serotonergic stimulation of the 5-ht2a/c receptors decreases dopamineric release in the frontal cortex.
I believe a drug like ritanserin would prove to be very usefull in the treatemtn of SSRI induced apathy.
Based on the actions of the MAOI, this effect may be experienced less frequently. MAO-B inhibitors seem to be very active cognative modulating agents. They seem to be effective in the treatment of ADD.Linkadge
Posted by rod on September 3, 2005, at 9:11:43
In reply to Re: Linkadge-AD/Frontal Lobe help?, posted by linkadge on September 3, 2005, at 6:59:24
Just curious. Does anyone know which role the PRE-frontal cortex plays? what does dopamine release do on the frontal lobe? I am asking because Anticonvulstants like depakote release dopamine in the prefornatl cortex.
Roland
Posted by linkadge on September 3, 2005, at 12:16:14
In reply to Pre-Frontal Cortex?, posted by rod on September 3, 2005, at 9:11:43
Yes, some anticonvulsants like depakote are more frontal cortex friendly than others.
Dopamine release in the frontal cortex creates a sence of self, a sence of presence. When dopamine gets released in the frontal cortex, it is able to shut down overactive limbic circutry.Ie when a normal person gets gets depressed, the frontal cortex is able more easily able to shut off the negative emotions.
So in essence the fronal cortex acts as a mediator for many other brain circuts, dopamine release activates it and is subsequently able to assert a degree of controll over the rest of the brain, emotionally, cognatively, whatever.
Linkadge
Posted by zeugma on September 3, 2005, at 16:17:08
In reply to Re: Pre-Frontal Cortex?, posted by linkadge on September 3, 2005, at 12:16:14
Dopamine release in the frontal cortex creates a sence of self, a sence of presence>>
this is exactly what I lack. Ritalin helped with this, Provigil to a much lesser degree.
this is why i think depersonalization disorders are not much helped by SSRI's. The problem with using stimulants to treat this condition is that very often they exacerbate the anxiety that is comorbid with depersonalization.-z
-z
Posted by linkadge on September 3, 2005, at 16:44:15
In reply to Re: Pre-Frontal Cortex? » linkadge, posted by zeugma on September 3, 2005, at 16:17:08
That is right. SSRI's never helped my depresionalization.
Linkadge
Posted by Phillipa on September 3, 2005, at 20:04:28
In reply to Re: Pre-Frontal Cortex?, posted by linkadge on September 3, 2005, at 16:44:15
Link, depresionalisation? Fondly, Phillipa
Posted by Jaydee on September 3, 2005, at 23:36:26
In reply to Re: Pre-Frontal Cortex?, posted by linkadge on September 3, 2005, at 16:44:15
Which is more effective for OCD: Phenlzine, or SSRI's?
any personal experiences/descriptions of MAOI vs SSRI ?
Posted by linkadge on September 4, 2005, at 8:12:26
In reply to Re: Pre-Frontal Cortex? » linkadge, posted by Phillipa on September 3, 2005, at 20:04:28
Depersonalization: based on the questionaire found at www.strangerinthemirror.com
- I have gone thru the motions of living while the real me was far away from what was happening to me.
- I have felt that I was living in a dream
- I have been able to see myself from a distance, as if I were outside of my body watching a movie of myself.
- I have purposely hurt or cut myself so that I could feel pain or that I am real.
- I feel as if I am "spacey".
- I have had the feeling that I was a stranger to myself or have not recognized myself in the mirror.
- I have felt as if parts of my body were disconnected from the rest of my body.
- My whole body or parts of it have seemed unreal or foreign to me.
- have felt that my emotions are not in my control
Posted by linkadge on September 4, 2005, at 8:19:19
In reply to Re: Pre-Frontal Cortex?, posted by Jaydee on September 3, 2005, at 23:36:26
It is difficult to say. Phenelzine is clearly superior in social phobia. But I am not sure how it compares in the OCD department.
I know that it is usefull in some treatement resistant OCD.
I've only tried Parnate. I would like to try nardil at some point. Parnate was very good and very bad at the same time. It was a very good drug for restoring my functionality but I would never report being happy on it. It was very unlike the SSRI's. Deep and intense. Nardil is supposed to be a little different.Parnate would definately be the superior drug to use for ADD related problems as it is structurally related to a stimulant. It is a stimulant and a MAOI in one.
Linkadge
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