Psycho-Babble Medication Thread 548273

Shown: posts 1 to 18 of 18. This is the beginning of the thread.

 

Most Effective Parnate Dosage for Social Phobia

Posted by johnb11 on August 29, 2005, at 17:06:10

Hi,

Could you share what has been your most effective Parnate dosage and the side effects you experienced at that dosage? I read a PubMed article suggesting a range of 40 - 60 mg/day. However, I know many psychopharmacologists will prescribe significantly above recommended dosages to obtain improved efficacy.

Thanks.

Johnb11

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by Declan on August 29, 2005, at 17:56:16

In reply to Most Effective Parnate Dosage for Social Phobia, posted by johnb11 on August 29, 2005, at 17:06:10

I think it's probably hard to generalise. Parnate doesn't really help with SP for me (although it is pleasurable), but when I take more than a little bit (10mg/d) I feel, I dunno, unbalanced or something. At any rate it's not an improvement. I suppose I could keep taking it waiting for remission, so to speak. And I think sex,(social phobia, and lots else) are helped by a good nights sleep.

So what to do there?

But maybe you sleep well enough on Parnate.

Declan

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by willyee on August 29, 2005, at 19:47:16

In reply to Most Effective Parnate Dosage for Social Phobia, posted by johnb11 on August 29, 2005, at 17:06:10

Parnate is a tricky medication.If youre just starting out you more than likly will get stimulant effects as you tirate upward,this is usualy pleaseant.

Parnate likes to poop-out,however just starting it you should be able to obtain some reliaf at lower doses than veteran usesrs are at.

Id first stay at a dose range of 20 mg - 40 mg.Most important thing is,listen to your body,there is no set dose because people respond so differently to this med.

Your body will tell you,and if you feel better at lower doses say around 30 mg,STAY there.More is not better,all u want to do is get to your therputic range,you dont want to push your way towards any high range dose.

There will come a time more likly,and unfortunatly when you have been on the drug and its starts to poop out and youll begin adjusting dosages,this is the downside of a once for me great med.

So enjoy all the anti depressant effects u get at the lower doses,try as hard as possable to stay low with therputic effect.

Just fyi purposes though,YES people have gone very high,one poster here could dose a 100 mg dose,he took 200 mg a day.I believe thats the highest ive seen,but a generaly high and common dose would be 80 mg - 120 mg.Good luck.

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by utopizen on August 29, 2005, at 20:14:38

In reply to Most Effective Parnate Dosage for Social Phobia, posted by johnb11 on August 29, 2005, at 17:06:10

What doses did you try of Klonopin? I tried like five dozen drug trials before Klonopin was finally used (I had to switch to my doc's colleague to get it, and regret not having the guts to do so sooner).

Klonopin gave you no relief? What dose? I take 1mg 3x/day, and these days, after a few years of it, I can get away often without any. Good ol' Klonopin saved me.

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by willyee on August 29, 2005, at 20:20:56

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by utopizen on August 29, 2005, at 20:14:38

> What doses did you try of Klonopin? I tried like five dozen drug trials before Klonopin was finally used (I had to switch to my doc's colleague to get it, and regret not having the guts to do so sooner).
>
> Klonopin gave you no relief? What dose? I take 1mg 3x/day, and these days, after a few years of it, I can get away often without any. Good ol' Klonopin saved me.


Parnate does get activating and accumaltes quickly,using a benzo on it is pretty common.

But you say 1mg,do you mean liqud deprenyl?? As far as i know parnate is only available as a ten mg tab correct?

P.S Klonopin can do wonders i agree.

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by willyee on August 29, 2005, at 20:23:08

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by willyee on August 29, 2005, at 20:20:56

nevermind i see you were speaking of klonopin only.

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by utopizen on August 29, 2005, at 20:26:43

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by willyee on August 29, 2005, at 20:23:08

> nevermind i see you were speaking of klonopin only.

Yeah, dude, I feel for you, having had it pretty bad-- but Klonopin + Lexapro basically squashed it.

I don't get it. Why Parnate? Klonopin has very good side effect profile.. Parnate... not so much.

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by willyee on August 29, 2005, at 20:34:37

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by utopizen on August 29, 2005, at 20:26:43

Well out of a thousand pounds of pills,the only two i ever had ANY actualy relieaf from were Maois,Parnate,Liquid Deprenyl,and partialy Molicmide.

Id love to get off parnate,but until the Maoi patch comes out i stuck,i dont tolerate ssris they drive me out a window and that removes just about every choce i have out there,also i usualy respond to pretty unconventional meds.

 

Re: Most Effective Parnate Dosage for Social Phobi » johnb11

Posted by Chairman_MAO on August 30, 2005, at 10:14:30

In reply to Most Effective Parnate Dosage for Social Phobia, posted by johnb11 on August 29, 2005, at 17:06:10

For social phobia, 120-200mg/day definitely worked a little better than lower dosages. I believe that for effective social phobia treatment, you really need at least the full 0.8mg/kg parnate. I think the least that worked for me was 60mg/day. 80mg/day was somewhat better.

 

Re: Most Effective Parnate Dosage for Social Phobi » willyee

Posted by Chairman_MAO on August 30, 2005, at 10:18:31

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by willyee on August 29, 2005, at 20:34:37

You really should give Nardil a try. One thing you could do is stay on Parnate and try LOW dosage Nardil (30-45 mg/day) simply for its GABAnergic effect, which will probably calm the overactivation of the Parnate somewhat.

You could also try Nardil with wellbutrin, which I think I am going to try next time I see my dr.

 

Re: Most Effective Parnate Dosage for Social Phobi » willyee

Posted by Chairman_MAO on August 30, 2005, at 10:18:47

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by willyee on August 29, 2005, at 20:34:37

You really should give Nardil a try. One thing you could do is stay on Parnate and try LOW dosage Nardil (30-45 mg/day) simply for its GABAnergic effect, which will probably calm the overactivation of the Parnate somewhat.

You could also try Nardil with wellbutrin, which I think I am going to try next time I see my dr.

 

Re: Most Effective Parnate Dosage for Social Phobi

Posted by Declan on August 30, 2005, at 14:58:40

In reply to Re: Most Effective Parnate Dosage for Social Phobi » willyee, posted by Chairman_MAO on August 30, 2005, at 10:18:47

I've tried to imagine what I would feel like on 80mg/d Parnate. It would be quite an experience. But I think I'd feel freaked out. It's not like I don't need anything either. I think my degree of social phobia is neither treatable nor problematic, just permanent reserve and uncomfortableness. Thinking about it is how I entertain myself. Like a certain social phobia is life, as in hell is other people and art, poetry and so on, well the stuff I like.
Declan

 

Re: Most Effective Parnate Dosage for Social Phobia

Posted by johnb11 on August 31, 2005, at 10:16:10

In reply to Re: Most Effective Parnate Dosage for Social Phobia, posted by utopizen on August 29, 2005, at 20:14:38

> What doses did you try of Klonopin? I tried like five dozen drug trials before Klonopin was finally used (I had to switch to my doc's colleague to get it, and regret not having the guts to do so sooner).
>
> Klonopin gave you no relief? What dose? I take 1mg 3x/day, and these days, after a few years of it, I can get away often without any. Good ol' Klonopin saved me.

------------------
I take Klonopin 2 mg day, and then as needed for presentations, etc. It seems to work significantly better, however, when used to augment another drug, such as Parnate or Nardil. Too much Klonopin makes me sleepy and also somewhat amnestic.

 

Re: Most Effective Parnate Dosage for Social Phobi

Posted by johnb11 on August 31, 2005, at 10:20:01

In reply to Re: Most Effective Parnate Dosage for Social Phobi » willyee, posted by Chairman_MAO on August 30, 2005, at 10:18:31

Combining Nardil with Parnate scares me a little bit. I'd be afraid of serotonin syndrome. My psychopharmacologist did try augmenting Nardil with Wellbutrin, but received no benefit, whatsoever.

By the way, if the Parnate doesn't work sufficiently well, I'll try high dosage Deprenyl (60 mg), with the hope that the higher dosage providing MAO A and B inhibiion. I tried this once, before, but just for 2 weeks. Think I need to probably give it a full 4 week trial.

 

Re: Most Effective Parnate Dosage for Social Phobi » johnb11

Posted by Chairman_MAO on August 31, 2005, at 16:45:59

In reply to Re: Most Effective Parnate Dosage for Social Phobi, posted by johnb11 on August 31, 2005, at 10:20:01

There is a drug called gastrodin, contained in the tuber gastrodia elata et blume used in chinese medicine, which is a GABA-T inhibitor with nootropic, anticonvulsant, anti-ischemic, and I think antioxidant properties. I have a feeling in sufficient dosages it would augment Parnate in SP to provide a Nardil-like GABAnergic effect.

 

Redirect: gastrodin

Posted by Dr. Bob on September 2, 2005, at 20:25:33

In reply to Re: Most Effective Parnate Dosage for Social Phobi » johnb11, posted by Chairman_MAO on August 31, 2005, at 16:45:59

> There is a drug called gastrodin...

Sorry to interrupt, but I'd like to redirect follow-ups regarding gastrodin to Psycho-Babble Alternative. Here's a link:

http://www.dr-bob.org/babble/alter/20050812/msgs/550076.html

Thanks,

Bob

 

Re: Most Effective Parnate Dosage for Social Phobi » Chairman_MAO

Posted by Jedi on September 3, 2005, at 2:23:31

In reply to Re: Most Effective Parnate Dosage for Social Phobi » willyee, posted by Chairman_MAO on August 30, 2005, at 10:18:47

> You really should give Nardil a try. One thing you could do is stay on Parnate and try LOW dosage Nardil (30-45 mg/day) simply for its GABAnergic effect, which will probably calm the overactivation of the Parnate somewhat.
>
> You could also try Nardil with wellbutrin, which I think I am going to try next time I see my dr.

Hey Chairman,
Have you used Parnate with low dose Nardil? What kind of response did you get? I've tried Parnate for depression & anxiety with seroquel added, which mostly seemed to counteract the Parnate "high" for me. It just didn't work on my treatment resistant atypical depression. Now 90mg Nardil with 1mg clonazepam seems to give me about a 75 to 80 percent recovery to normal. But I am always struggling for that last 20 percent. I was on Wellbutrin SR with Nardil for some time and it seemed like a really good combination. Then my previous PDOC retired and I went to a major University Hospital to see supposedly one of the best PDOCs in the country for treatment resistant depression. Of course, he told me the combination was going to kill me and thought I should do ECT instead. Thanks a lot. I think I could probably present enough documentation to my current GP to let me try it again. The Wellbutrin seemed to help with a lot of the Nardil side effects but I remember it did seem to make me think a little slower. Another thought is going back to the Nardil with Nortriptyline. This combo worked pretty well and some research suggests that a MAOI with some tricyclics will help lessen the chance of a hypertensive crisis. Have you done any study on this? My other thought is to reduce my Nardil dose down to about 60mg and raise the clonazepam to 3mg per day. In theory this should lessen the Nardil side effects while raising the gaba even more to treat my social and generalized anxiety. Any thoughts on this combination? Thanks for any advice you might have.
Jedi

 

Re: Most Effective Parnate Dosage for Social Phobi

Posted by willyee on September 3, 2005, at 14:42:51

In reply to Re: Most Effective Parnate Dosage for Social Phobi » Chairman_MAO, posted by Jedi on September 3, 2005, at 2:23:31

I have,not really effective


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