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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by linkadge on July 14, 2005, at 21:01:10
http://www.psychiatryinpractice.com/psychiatryinpractice/ImageBankView.aspx?contentId=10
Posted by linkadge on July 14, 2005, at 21:06:00
In reply to cool AP binding chart, posted by linkadge on July 14, 2005, at 21:01:10
Mind you, this link is the biggest waste of time.
http://www.psychiatryinpractice.com/psychiatryinpractice/ImageBankView.aspx?contentId=356
Linkadge
Posted by sleepygirl on July 14, 2005, at 21:48:59
In reply to Re: cool AP binding chart, posted by linkadge on July 14, 2005, at 21:06:00
THAT was a very interesting picture!! Thanks for the pie chart links, good for those of us too lazy to do all the neurotransmitter binding site research stuff :-)
-sleepy
Posted by sleepygirl on July 14, 2005, at 21:50:09
In reply to cool AP binding chart, posted by linkadge on July 14, 2005, at 21:01:10
Holy H1 receptor on Seroquel!!! Is that the one that makes you tired?!! Holy crap! no wonder...
Posted by sleepygirl on July 14, 2005, at 21:54:52
In reply to cool AP binding chart, posted by linkadge on July 14, 2005, at 21:01:10
OK sorry for all the stalking... but H is for histamine, 5HT is serotonin, D is for dopamine right?? but what's the straight A1, A2 and the M if you don't mind?
Posted by yxibow on July 15, 2005, at 1:58:44
In reply to Re: cool AP binding chart, posted by sleepygirl on July 14, 2005, at 21:54:52
> OK sorry for all the stalking... but H is for histamine, 5HT is serotonin, D is for dopamine right?? but what's the straight A1, A2 and the M if you don't mind?
I believe A1 is the alpha-adrenergic receptor that is responsible for orthostatic hypotension (low blood pressure) in SeroquelThe "M" muscarinic receptor profiles are more complicated, but are named for the "fly agaric mushroom" Amanita muscaria; antagonists are anticholinergics.
I'm sure ed_uk could add more...
Posted by xbunny on July 15, 2005, at 4:36:59
In reply to cool AP binding chart, posted by linkadge on July 14, 2005, at 21:01:10
> http://www.psychiatryinpractice.com/psychiatryinpractice/ImageBankView.aspx?contentId=10
thats pretty cool but half of olanzapine seems to be missing, or is it all M?
Posted by rjlockhart98 on July 15, 2005, at 9:36:16
In reply to Re: cool AP binding chart, posted by xbunny on July 15, 2005, at 4:36:59
Haldol seems to be the most "dopamine" blocking.
Is there a diffrence in the effects on how your perception is changed by which transmitter is more effected?
What about Thorazine?
Posted by yxibow on July 15, 2005, at 15:23:02
In reply to Re: cool AP binding chart, posted by rjlockhart98 on July 15, 2005, at 9:36:16
> Haldol seems to be the most "dopamine" blocking.
>...and among ones that causes the most EPS/TD as well... Haldol is very cheap, but I think more "kinder, gentler" atypicals should be used before resorting to it unless the disorder in hand is very uncontrollable
> Is there a diffrence in the effects on how your perception is changed by which transmitter is more effected?
>
> What about Thorazine?the chart [fig 18.6] (I was trying to find another similar one that included more modern medications)
shows relative binding of certain older neuroleptics
http://www.chemistry.emory.edu/justice/chem190j/pharmaco.htm
Posted by sleepygirl on July 15, 2005, at 20:40:51
In reply to Re: cool AP binding chart, posted by yxibow on July 15, 2005, at 1:58:44
This is the end of the thread.
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