Psycho-Babble Medication Thread 386220

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Mirtazapine / Remeron conclusion??????

Posted by Waki on September 3, 2004, at 23:22:33

I am confused by some posting conclusions.

Whats the final 411 on the med called Mirtazapine / Remeron?

I am specificly looking for one of these three answers.

1) It's sedating and after a couple weeks at higer doses becomes stimulating.

2) Is sedating

3) Is stimulating and can even cause anger.

4) If I missed a possibality please add it in to my three.

Thanx.

 

Re: Mirtazapine / Remeron conclusion??????

Posted by Jasmineneroli on September 4, 2004, at 1:58:58

In reply to Mirtazapine / Remeron conclusion??????, posted by Waki on September 3, 2004, at 17:13:37

I tried Remeron a year ago and HATED it!
In my experience:
Yes, it's extremely sedating, at lower doses, and I found it to still make me dozy at 45mg! According to my research from last year, at lower doses, the histamine response is predominant at doses less than 45mg, hence the sedation. (Actually, I was plain "drunk",slurred speech and everything!). Above 30mg it begins to effect norepinephrine and also some serotonin receptors, which is supposed to be more noticeable at 45mg.
So at that level it can be a little stimulating or more like an alertness/focussed effect. I didn't experience that at all, however. Just drowsiness, fluid retention and wierd stuff. I did not feel any anger, nor did I read about it at the time. But a related effect was a lack of inhibition...I did some very dumb things, took risks, made a few poor decisions, and had an " I don't care" attitude. I've since read reports that Remeron has caused people to do things against their usual better judgement, like stealing!! I don't know how common that is.
Hope that helps.
Jas

 

Re: Mirtazapine / Remeron conclusion?????? » Waki

Posted by Sad Panda on September 4, 2004, at 3:53:57

In reply to Mirtazapine / Remeron conclusion??????, posted by Waki on September 3, 2004, at 17:13:37

> I am confused by some posting conclusions.
>
> Whats the final 411 on the med called Mirtazapine / Remeron?
>
> I am specificly looking for one of these three answers.
>
> 1) It's sedating and after a couple weeks at higer doses becomes stimulating.
>
> 2) Is sedating
>
> 3) Is stimulating and can even cause anger.
>
> 4) If I missed a possibality please add it in to my three.
>
> Thanx.
>

Mirtazapine is a strange drug the rarely is of much use on it's own, but it's a great to add on to an SSRI or Effexor. It has three distinctly different actions at several different receptor sites.

1. It is the most potent antihistamine available, making it extremely sedating at low doseages.

2. After it has saturated H1 receptors, it then proceeds to block 5-HT2 & 5-HT3 receptors which provides relief from SRI induced side effects at medium doseages(insomnia, anorgasmia, night sweats & nausea).

3. At high doseages it antagonises NE Alpha-2 receptors which can be stimulating in a good way or a bad way. It was the bad kind for me & caused me to be cranky, irritability & gave me mild RLS.

If you haven't had any luck with the SRI kind of drugs, try an NRI type TCA such as Nortriptyline first.

Cheers,
Panda.



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