Psycho-Babble Medication Thread 385411

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Posted by aazospiro on September 1, 2004, at 19:48:10

What is REALLY responsible for the calming effects of a psychostimulant?? Serotonin/ Dopamine/ norepinephrine???

Or is it a complex interaction? And what about the graduall decline in the calming effects of a stimulant? Does this mean a serotonin depletion? Can it explain stimulant tolerance?

The reason I ask this is that I found that after 6 months on a stimulant the calming effects seemed to gradually decline in intensity and duration, but when I took a single dose of 20 mg prozac, it came right back again AS CALM AS A CUCUMBER!!!! and over a period of a a few days the stimulant calming effects declined again.

I chose to take only one prozac because of its long half life and active metabolite and monitor my behaviour. And it seems to work.

I had an almost identical effect when I combined a single tablet of 100/10 Sinemet and supplemental 5-hydroxytryptophan, but for obvious reasons the effect lasted much shorter than with the prozac.

The effect can best be described as very calm, very focused and a HUGE drop in jitteryness, restlessnes and anxiety both psychologic and somatic [hand tremor].

My symptoms from the age of 13 always consisted of the following:

1. Anxiety [foot shaking, hand tremor, butterflies] and especially in social situations, not so much on a "one on one" basis but especially amongst several people.

2. Severe inner restlessnes [nail biting, foot shaking]

3. Inability to concentrate on any one thing unless it was VERY interesting to me, and if that were the case, a very difficult time diverting my attention away from that one thing to another. In otherwords, multitasking was disastrous.

3. Hard to get going on mornings 9 out of 10 times. Severe drowsiness during the day especially afternoons regardless of how much sleep I had the previous night. And difficulty falling asleep at nights. Up late if a sleeping aid wasnt taken.

4. Low self esteem, short temper, slight to moderate agitation that was at its worse when daytime drowsiness set in.

Anyone else experience this??



Posted by Colleen D. on September 1, 2004, at 21:03:23

In reply to SEROTONIN PARADOXIC STIMULANT!!, posted by aazospiro on September 1, 2004, at 19:48:10

Sorry I don't have an answer for you regarding which neurotransmitter is responsible for a calming effect, but WOW, your symptoms sound very much like my symptoms since I was a teenager. I'm interested in other responses you may get to your post as there are some incredibly knowledgable on this forum. Have you been diagnosed with any particular disorders? I have been diagnosed with depression, general anxiety and OCD. Do you happen to become obsessed with detail when you are very interested in something like I do?




Posted by katalina on September 2, 2004, at 9:46:14

In reply to SEROTONIN PARADOXIC STIMULANT!!, posted by aazospiro on September 1, 2004, at 19:48:10

Hi there,

Your symptoms also sound similar to mine. What are you taking for a stimulant, and what dose? I take Adderall (about 60 mgs. per day) w/o an SSRI. I used to take prozac, effexor and lexapro (all at different times of course) with the Adderall but I haven't in about 6 months. I wonder if the tolerance I'm experiencing to Adderall could be improved if I added back the prozac? Interesting.

Thanks for the thought provoking post,


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