Psycho-Babble Medication Thread 384994

Shown: posts 1 to 11 of 11. This is the beginning of the thread.

 

Question for SLS

Posted by linkadge on August 31, 2004, at 20:23:42

You mentioned that you get a rebound improvement whenever you quit a tryciclic. What do you think contributes to this ?, Do you get this with other antidepressants ?

I get rebound improvement when I quit antidepressants. I start to get messages that I was better off without them. Then I feel like god was trying to tell me something. Then, about 3 weeks later I'm really depressed and mildly psychotic.

But I certainly do feel a transient sence of freedom and emotional improvement, it always fades however. I have been trying to figure out the mechanisms for this.

I think that AD's in some sence can act as stabalizers. They seem to alert me to my problems. They sometimes get me thinking/planning way too far ahead. It seems when I come off them I feel very much in the present. But too long off them and I panic because I havn't been thinking about the future :)

Linkadge


 

Re: Question for SLS

Posted by SLS on September 1, 2004, at 6:57:53

In reply to Question for SLS, posted by linkadge on August 31, 2004, at 20:23:42

Hi Linkadge.

> You mentioned that you get a rebound improvement whenever you quit a tryciclic. What do you think contributes to this ?,

The best I can come up with is that it has to do with changes in receptor sensitivity. My guess is that it is NE related, as this only happens to me with TCAs and MAOIs, and not SSRIs.

> I get rebound improvement when I quit antidepressants. I start to get messages that I was better off without them. Then I feel like god was trying to tell me something. Then, about 3 weeks later I'm really depressed and mildly psychotic.

That's about right. My post-discontinuation improvement lasts for about 2-3 weeks before I experience a noticeable deterioration.

> But I certainly do feel a transient sence of freedom and emotional improvement, it always fades however. I have been trying to figure out the mechanisms for this.

So, you experience this with SSRIs too? How would you compare your experiences with Effexor? What about TCAs?

Transient discontinuation rebound improvements (or even improvements upon dosage reduction) with TCAs have been reported numerous times in the literature. I don't see them with SSRIs.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3435883


- Scott


 

Re: Question for SLS

Posted by linkadge on September 1, 2004, at 7:54:39

In reply to Re: Question for SLS, posted by SLS on September 1, 2004, at 6:57:53

I have heard reports of rebound mania with the SSRIs. I would assume it is because of a dopamine rebound rush. It seems I only get this if I am discontinuing a high dose of SSRI. If it is a low dose I feel depression immeditely.

Have not taken a TCA, but effexor caused rebound improvement I can only describe by a sence of "relief". It worked as an antidepressant but do you know that sence of euphoria you get when something challenging ends. Like when shool exams end I get a sence of freedom, like I can do what I want to do now. Thats the feeling I get when stopping effexor.


Linkadge

 

Re: Question for SLS

Posted by King Vultan on September 1, 2004, at 7:58:45

In reply to Re: Question for SLS, posted by SLS on September 1, 2004, at 6:57:53

I've experienced this with both SSRIs and TCAs--the drugs that come most to mind being Zoloft and desipramine respectively. I guess I figured it had something to do with dopamine being suppressed while on the AD and then returning to normal levels, or perhaps rebounding to slightly above normal levels upon discontinuation of the AD. The reason I feel it is dopamine related is that there was a definite and significant increase in libido accompanying the discontinuation, as well as a feeling that might be described as a mild euphoria. I recall this feeling lasting for a few days after dumping Zoloft (this happened on more than one occasion, as I periodically would get dissatisfied with my state of mind while on Zoloft and drop the med), but for perhaps a couple weeks or so after discontinuing desipramine.

Todd

 

Re: Question for SLS

Posted by SLS on September 1, 2004, at 8:44:18

In reply to Re: Question for SLS, posted by King Vultan on September 1, 2004, at 7:58:45

I guess it could very well be dopamine if such occurs with SSRIs as well as tricylics. However, don't forget that even SSRIs downregulate NE beta receptors.


- Scott

 

not all SSRI's downregulate beta adrenoreceptors

Posted by linkadge on September 1, 2004, at 9:17:10

In reply to Re: Question for SLS, posted by SLS on September 1, 2004, at 8:44:18

I read a recent study that showed celexa did *not* downregulate the adrenoreceptors like did sertraline or paroxetine. It did however downregulate the 5-ht2a receptors. Personally I do not find celexa as good for panic as zoloft or paxil. I am looking for more studies


Linkadge

 

Re: not all SSRI's downregulate beta adrenoreceptors

Posted by King Vultan on September 1, 2004, at 10:21:19

In reply to not all SSRI's downregulate beta adrenoreceptors, posted by linkadge on September 1, 2004, at 9:17:10

> I read a recent study that showed celexa did *not* downregulate the adrenoreceptors like did sertraline or paroxetine. It did however downregulate the 5-ht2a receptors. Personally I do not find celexa as good for panic as zoloft or paxil. I am looking for more studies
>
>
> Linkadge


I wonder is this has anything to do with Celexa being more or less a pure SSRI, as opposed to sertraline and paroxetine, which both have at least a mild effect on norepinephrine reuptake.

Todd

 

Re: not all SSRI's downregulate beta adrenoreceptors

Posted by linkadge on September 1, 2004, at 11:28:14

In reply to Re: not all SSRI's downregulate beta adrenoreceptors, posted by King Vultan on September 1, 2004, at 10:21:19

Thats what I would think. Personally I felt that celexa makes me feel different than zoloft or paxil.

Linkadge

 

Re: Question for SLS

Posted by 4WD on September 1, 2004, at 21:06:36

In reply to Question for SLS, posted by linkadge on August 31, 2004, at 20:23:42

I also get a rebound improvement when I d/c Effexor. I feel less drugged, more alive, more energy, generally better for a couple of weeks. I also find it much easier to have orgasms and much better orgasms. I just figured that part of it was because I was no longer taking the orgasm-dampening drug.

Marsha

 

Re: not all SSRI's downregulate beta adrenoreceptors

Posted by Sad Panda on September 3, 2004, at 11:51:08

In reply to Re: not all SSRI's downregulate beta adrenoreceptors, posted by King Vultan on September 1, 2004, at 10:21:19

> > I read a recent study that showed celexa did *not* downregulate the adrenoreceptors like did sertraline or paroxetine. It did however downregulate the 5-ht2a receptors. Personally I do not find celexa as good for panic as zoloft or paxil. I am looking for more studies
> >
> >
> > Linkadge
>
>
> I wonder is this has anything to do with Celexa being more or less a pure SSRI, as opposed to sertraline and paroxetine, which both have at least a mild effect on norepinephrine reuptake.
>
> Todd
>
>

It's not really pure, only marketed that way. Celexa blocks H1 receptors next rather than the other reuptake sites.

Cheers,
Panda.

 

Re: not all SSRI's downregulate beta adrenoreceptors

Posted by linkadge on September 5, 2004, at 8:38:55

In reply to Re: not all SSRI's downregulate beta adrenoreceptors, posted by Sad Panda on September 3, 2004, at 11:51:08

So its an antihistamine ??

Strange. It can't be as much of an antihistamine as paxil is. I could really feel that antihistamine effect.

Linkadge


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